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The Rowett Institute

Newsletters and Publications

Newsletters and Publications
Newsletters

2014

  • Summer - including research briefs by Nikki Cassie and Professor John-Olov Jansson

2012

  • Winter - including Dr Graham Finlayson's research brief "Eating on the run"
  • Spring - including Dr John Menzies's research brief "Why is eating so rewarding?"

2011

  • Winter - including Dr Sebastien Bouret's research brief "You are what your Mum ate."
Original Research
2016

GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness.
Svendsen B, Pais R, Engelstoft MS, Milev NB, Richards P, Christiansen CB, Egerod KL, Jensen SM, Habib AM, Gribble FM, Schwartz TW, Reimann F, Holst JJ.
J Endocrinol. 2016 Jan; 228(1):39-48. doi: 10.1530/JOE-15-0247. Epub 2015 Oct 19.
PMID: 26483393

Subtypes of trait impulsivity differentially correlate with neural responses to food choices.
van der Laan LN, Barendse ME, Viergever MA, Smeets PA.
Behav Brain Res. 2016 Jan 1;296:442-50. doi: 10.1016/j.bbr.2015.09.026. Epub 2015 Sep 21.
PMID: 26393430

2015

The biology of appetite control: Do resting metabolic rate and fat-free mass drive energy intake?
Blundell JE, Finlayson G, Gibbons C, Caudwell P, Hopkins M.
Physiol Behav. 2015 Dec 1;152(Pt B):473-8. doi: 10.1016/j.physbeh.2015.05.031. No abstract available

The effect of encapsulated glutamine on gut peptide secretion in human volunteers. Meek CL, Lewis HB, Vergese B, Park A, Reimann F, Gribble F.
Peptides. 2015 Nov 2. pii: S0196-9781(15)00290-9. doi: 10.1016/j.peptides.2015.10.008. [Epub ahead of print]
PMID: 26541888

The Stomach-Derived Hormone Ghrelin Increases Impulsive Behavior. Anderberg RH, Hansson C, Fenander M, Richard JE, Dickson SL, Nissbrandt H, Bergquist F, Skibicka KP.
Neuropsychopharmacology. 2015 Oct 1. doi: 10.1038/npp.2015.297. [Epub ahead of print]
PMID: 26424164

Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine. Christensen LW, Kuhre RE, Janus C, Svendsen B, Holst JJ.
Physiol Rep. 2015 Sep;3(9). pii: e12551. doi: 10.14814/phy2.12551.
PMID: 26381015

Postprandial profiles of CCK after high fat and high carbohydrate meals and the relationship to satiety in humans.
Gibbons C, Finlayson G, Caudwell P, Webb DL, Hellström PM, Näslund E, Blundell JE.
Peptides. 2015 Sep 30. pii: S0196-9781(15)00270-3. doi: 10.1016/j.peptides.2015.09.010. [Epub ahead of print]
PMID: 26429068

Prolonged Adaptation to a Low or High Protein Diet Does Not Modulate Basal Muscle Protein Synthesis Rates - A Substudy.
Hursel R, Martens EA, Gonnissen HK, Hamer HM, Senden JM, van Loon LJ, Westerterp-Plantenga MS. PLoS One. 2015 Sep 14;10(9):e0137183. doi: 10.1371/journal.pone.0137183. eCollection 2015.
PMID: 26367529

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons.
Steculorum SM, Paeger L, Bremser S, Evers N, Hinze Y, Idzko M, Kloppenburg P, Brüning JC.
Cell. 2015 Sep 10;162(6):1404-17. doi: 10.1016/j.cell.2015.08.032.
PMID: 26359991

Standardized food images: A photographing protocol and image database. Appetite.
Charbonnier L, van Meer F, van der Laan LN, Viergever MA, Smeets PA
2015 Sep 4;96:166-173. doi: 10.1016/j.appet.2015.08.041. [Epub ahead of print] . PMID: 26344127

Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells.
Pais R, Gribble FM, Reimann F.
Peptides. 2015 Jul 26. pii: S0196-9781(15)00215-6. doi: 10.1016/j.peptides.2015.07.019. [Epub ahead of print]
PMID: 26215048

Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin.
van der Plasse G, van Zessen R, Luijendijk MC, Erkan H, Stuber GD, Ramakers GM, Adan RA.
Int J Obes (Lond). 2015 Jul 17. doi: 10.1038/ijo.2015.131. [Epub ahead of print] PMID: 26183405

Functional MRI of Challenging Food Choices: Forced Choice between Equally Liked High- and Low-Calorie Foods in the Absence of Hunger.
Charbonnier L, van der Laan LN, Viergever MA, Smeets PA.
PLoS One. 2015 Jul 13;10(7):e0131727. doi: 10.1371/journal.pone.0131727. eCollection 2015.
PMID: 26167916

High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Richards P, Pais R, Habib AM, Brighton CA, Yeo GS, Reimann F, Gribble FM.
Peptides. 2015 Jul 3. pii: S0196-9781(15)00189-8. doi: 10.1016/j.peptides.2015.06.006. [Epub ahead of print]
PMID: 26145551

Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells.
Moss CE, Glass LL, Diakogiannaki E, Pais R, Lenaghan C, Smith DM, Wedin M, Bohlooly-Y M, Gribble FM, Reimann F.
Peptides. 2015 Jul 2. pii: S0196-9781(15)00195-3. doi: 10.1016/j.peptides.2015.06.012. [Epub ahead of print]
PMID: 26144594

Perinatal overnutrition exacerbates adipose tissue inflammation caused by high-fat feeding in C57BL/6J mice. Kayser BD, Goran MI, Bouret SG.
PLoS One. 2015 Apr 2;10(3):e0121954. doi: 10.1371/journal.pone.0121954. eCollection 2015.
PMID: 25835281

Differences in food intake of tumour-bearing cachectic mice are associated with hypothalamic serotonin signalling.
Dwarkasing JT, Boekschoten MV, Argilès JM, van Dijk M, Busquets S, Penna F, Toledo M, Laviano A, Witkamp RF, van Norren K. J
Cachexia Sarcopenia Muscle. 2015 Mar;6(1):84-94. doi: 10.1002/jcsm.12008. Epub 2015 Mar 31. PMID: 26136415

FTO is necessary for the induction of leptin resistance by high-fat feeding. Tung YC, Gulati P, Liu CH, Rimmington D, Dennis R, Ma M, Saudek V, O'Rahilly S, Coll AP, Yeo GS.
Mol Metab. 2015 Feb 7;4(4):287-98. doi: 10.1016/j.molmet.2015.01.011. eCollection 2015.
PMID: 25830092

Molecular mechanisms of glucose-stimulated GLP-1 secretion from perfused rat small intestine.
Kuhre RE, Frost CR, Svendsen B, Holst JJ.
Diabetes. 2015 Feb;64(2):370-82. doi: 10.2337/db14-0807. Epub 2014 Aug 25.
PMID: 25157092

Targeting development of incretin-producing cells increases insulin secretion. Petersen N, Reimann F, van Es JH, van den Berg BM, Kroone C, Pais R, Jansen E, Clevers H, Gribble FM, de Koning EJ.
J Clin Invest. 2015 Jan;125(1):379-85. doi: 10.1172/JCI75838. Epub 2014 Dec 15. PMID: 25500886

Ghrelin programs development of hypothalamic feeding circuits
Steculorum SM, Collden G, Coupe B, Croizier S, Andrews Z, Jarosch F, Klussmann S, Bouret SG.
2015 The Journal of Clinical Investigation, 125(2): 846-858, 2015. doi: 10.1172/JCI73688
PMID: 25607843

Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin
Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, Bouret SG.
Molecular Metabolism, 4(1):15-24, 2015. doi: 10.1016/j.molmet.2014.10.003
PMID: 25685686

Dietary Polyunsaturated Fatty Acids Increase Survival and Decrease Bacterial Load during Septic Staphylococcus aureus Infection and Improve Neutrophil Function in Mice
Svahn SL, Grahnemo L, Pálsdóttir V, Nookaew I, Wendt K, Gabrielsson B, Schéle E, Benrick A, Andersson N, Nilsson S, Johansson ME, Jansson JO.
Infect Immun 83:514-521. doi: 10.1128/IAI.02349-14
PMID: 25404025
2014

Protein leverage effects of beef protein on energy intake in humans
Martens EA, Tan S-Y, Dunlop MV, Mattes RD, Westerterp-Plantenga MS.
PMID: 24760974
Am J Clin Nutr. 2014 Jun;99(6):1397-406. doi: 10.3945/ajcn.113.078774. Epub 2014 Apr 23.

Maintenance of energy expenditure on high-protein diets at a constant body weight may prevent a positive energy balance.
Martens EA, Gonnissen HK, Gatta-Cherifi B, Janssens PL, Westerterp-Plantenga MS.
Clin Nutr. 2014 Nov 8. pii: S0261-5614(14)00259-3. doi: 10.1016/j.clnu.2014.10.007. PMID: 25466951

Combined use of the canine adenovirus-2 and DREADD-technology to activate specific neural pathways in vivo.Boender et al
PLoS One. 2014 Apr 15;9(4):e95392. doi: 10.1371/journal.pone.0095392
PMID: 24736748

Psychobiological examination of liking and wanting for fat and sweet taste in trait binge eating females.
Dalton M, Finlayson G.
Physiology & Behavior 2014; 136: 128-134. doi: 10.1016/j.physbeh.2014.03.019 PMID: 24662699

The adaptive metabolic response to exercise-induced weight loss influences both energy expenditure and energy intake.
Hopkins, M., C. Gibbons, P. Caudwell, P. M. Hellström, E. Näslund, N. King, G. Finlayson and J. Blundell
European Journal of Clinical Nutrition, 68(5), pp.581-586. doi: 10.1038/ejcn.2013.277 PMID: 24398647

Denervation suppresses gastric tumorigenesis.
Zhao CM, Hayakawa Y, Kodama Y, Muthupalani S, Westphalen CB, Andersen GT, Flatberg A, Johannessen H, Friedman RA, Renz BW, Sandvik AK, Beisvag V, Tomita H, Hara A, Quante M, Li Z, Gershon MD, Kaneko K, Fox JG, Wang TC, Chen D.
Sci Transl Med. 2014;6:250ra115. doi: 10.1126/scitranslmed.3009569.
PMID: 25143365

An analysis of co-secretion and co-expression of gut hormones from male rat proximal and distal small intestine
Svendsen B, Pedersen J, Wewer Albrechtsen NJ, Hartmann B, Rehfeld JF, Poulsen SS, Holst JJ.
Endocrinology, Dec 2014 doi: 10.1210/en.2014-1710 PMID: 25535831

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance. Tsaousidou E, Paeger L, Belgardt BF, Pal M, Wunderlich CM, Brönneke H, Collienne U, Hampel B, Wunderlich FT, Schmidt-Supprian M, Kloppenburg P, Brüning JC
(2014) Cell Rep. 9 1495-506. doi: 10.1016/j.celrep.2014.10.045
PMID: 25456138

The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas.
Arjen J. Boender, Margriet A. van Gestel, Keith M. Garner, Mieneke C. M. Luijendijk & Roger A. H. Adan.
Physiol Rep, 2 (7), 2014, e12083, doi: 10.14814/phy2.12083
PMID: 25077509

AAV-Mediated Gene Transfer of the Obesity-Associated Gene Etv5 in Rat Midbrain Does Not Affect Energy Balance or Motivated Behavior.
Arjen J. Boender, Nivard A. Koning, José K. van den Heuvel, Mieneke C. M. Luijendijk, Andrea J. van Rozen, Susanne E. la Fleur, Roger A. H. Adan.
PLOS ONE | www.plosone.org 1 April 2014 | Volume 9 | Issue 4 | e94159
PMID: 24710089

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain
Eglantine Balland, Julie Dam, Fanny Langlet, Emilie Caron, Sophie Steculorum, Andrea Messina, S. Rasika, Anthony Falluel-Morel, Youssef Anouar, Bénédicte Dehouck, Eric Trinquet, Ralf Jockers, Sebastien G. Bouret, and Vincent Prévot.
Cell Metabolism 19, 293–301, February 4, 2014 doi: 10.1016/j.cmet.2013.12.015
PMID: 24506870

Leptin-dependent neuronal NO signalling in the preoptic hypothalamus facilitates reproduction
Nicole Bellefontaine, Konstantina Chachlaki, Jyoti Parkash, Charlotte Vanacker, William Colledge, Xavier d’Anglemont de Tassigny, John Garthwaite, Sebastien G. Bouret, and Vincent Prevot.
J Clin Invest. 2014;124(6):2550–2559. doi:10.1172/JCI65928.
PMID: 24812663

Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training
Mark Hopkins, Catherine Gibbons, Phillipa Caudwell, Dominic-LucWebb, PerM. Hellström, Erik Näslund, John E. Blundell, and Graham Finlayson
International Journal of Endocrinology Volume 2014, Article ID 323728, doi:10.1155/2014/323728
PMID: 24734042

Studying eating behaviour in humans
Catherine Gibbons, Graham Finlayson, Michelle Dalton, Phillipa Caudwell and John E Blundell
Journal of Endocrinology (2014) 222, G1–G12 doi: 10.1530/JOE-14-0020
PMID: 25052364

Influence of ghrelin on the central serotonergic signaling system in mice
Caroline Hansson, Mayte Alvarez-Crespo, Magdalena Taube, Karolina P. Skibicka, Linnéa Schmidt, Linda Karlsson-Lindahl, Emil Egecioglu, Hans Nissbrandt & Suzanne L. Dickson
Neuropharmacology 79 (2014) 498-505. doi:10.1016/j.neuropharm.2013.12.012
PMID: 24373901

GLP-1 Receptor Stimulation of the Lateral Parabrachial Nucleus Reduces Food Intake: Neuroanatomical, Electrophysiological, and Behavioral Evidence
Jennifer E. Richard, Imre Farkas, Fredrik Anesten, Rozita H. Anderberg, Suzanne L. Dickson, Fiona M. Gribble, Frank Reimann, John-Olov Jansson, Zsolt Liposits, and Karolina P. Skibicka
Endocrinology, November 2014, 155(11):4356–4367 doi: 10.1210/en.2014-1248 PMID: 25116706

Sweet lies: neural, visual, and behavioural measures reveal a lack of self-control conflict during food choice in weight-concerned women
Laura N. van der Laan, Denise T.D. de Ridder, Lisette Charbonnier, Max A. Viergever and Paul A.M. Smeets
Frontiers in Behavioral Neuroscience May2014 8: Article 184 doi: 10.3389/fnbeh.2014.00184
PMID: 24904336

Activation in inhibitory brain regions during food choice correlates with temptation strength and self-regulatory success in weight-concerned women
Laura NynkevanderLaan, Denise T.D. deRidder, Max A. Viergever and Paul A.M. Smeets
Frontiers in Neuroscience September 2014 | Volume 8 | Article 308 doi: 10.3389/fnins.2014.00308
PMID: 25324714

Hypothalamic food intake regulation in a cancer-cachectic mouse model
Jvalini T. Dwarkasing & Miriam van Dijk & Francina J. Dijk & Mark V. Boekschoten & Joyce Faber & Josep M. Argilès & Alessandro Laviano & Michael Müller & Renger F. Witkamp & Klaske van Norren
J Cachexia Sarcopenia Muscle (2014) 5:159–169 doi: 10.1007/s13539-013-0121-y
PMID: 24222472

The neuroanatomical function of leptin in the hypothalamus
van Swieten , R. Pandit , R.A.H. Adan , G. van der Plasse (2014)
Journal of Chemical Neuroanatomy 61-62: 207-220 doi:10.1016/j.jchemneu.2014.05.004
PMID: 25007719

Fat mass and obesity related (FTO) shuttles between the nucleus and cytoplasm.
Gulati, P, Avezov, E, Ma, M, Antrobus, R, Lehner, P, O’Rahilly, S, Yeo, G.S.H. (2014)
Biosci. Rep. 34(5), art:e00144. doi:10.1042/BSR20140111
PMID: 25242086

The potential of a high-protein, low-carbohydrate diet to preserve intrahepatic triglyceride content in healthy humans.
Martens EA, Gatta-Cherifi B, Gonnissen HK, Westerterp-Plantenga MS.
PLoS One 2014;16:9
PMID: 25330327

Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors
Chun-Mei Zhao, Yosuke Kodama, Arnar Flatberg, Vidar Beisvag, Bård Kulseng, Arne K. Sandvik,Jens F. Rehfeld, Duan Chen.
Regulatory Peptides 192–193 (2014) 35–44
PMID 25160855

No protein intake compensation for insufficient indispensable amino acid intake with a low-protein diet for 12 days
Martens EA, Tan SY, Mattes RD, and Westerterp-Plantenga MS
Nutrition and Metabolism 2014;11:38.
PMID 25183991

Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats.
OA Gudbrandsen, Y Kodama, SA Mjøs, C-M Zhao, H Johannessen, H-R Brattbakk, C Haugen, B Kulseng, G Mellgren and D Chen.
Nutrition & Diabetes (2014) 4, e124; doi:10.1038/nutd.2014.22
PMID 24979153

Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat.
T Bake, DGA Morgan & JG Mercer
Physiology and Behavior 10 April 2014, Pages 70–79
PMID 24518863

The Interaction Between Exercise, Appetite, and Food Intake Implications for Weight Control
King, N. A., K. Horner, A. P. Hills, N. M. Byrne, R. E. Wood, E. Bryant, P. Caudwell, G. Finlayson, C. Gibbons and M. Hopkins.
American Journal of Lifestyle Medicine, 7(4), pp.265-273. Doi: 10.1177/1559827613475584

Mechanistic comparison between gastric bypass vs. duodenal switch with sleeve gastrectomy in rat models.
Kodama Y, Johannessen H, Furnes MW, Zhao CM, Johnsen G, Mårvik R, Kulseng B, Chen D.
PLoS One. 2013;8(9):e72896. doi: 10.1371/journal.pone.0072896. eCollection 2013. PMID: 24039816

Eating behavior and glucagon-like peptide-1-producing cells in interposed ileum and pancreatic islets in rats subjected to ileal interposition associated with sleeve gastrectomy.
Johannessen H, Kodama Y, Zhao CM, Sousa MM, Slupphaug G, Kulseng B, Chen D.
Obes Surg. 2013;23:39-49. doi: 10.1007/s11695-012-0750-9.
PMID:2294901

Mechanistic Comparison between Gastric Bypass vs. Duodenal Switch with Sleeve Gastrectomy in Rat Models
Kodama Y, Johannessen H, Furnes MW, Zhao C-M, Johnsen G, Mårvik R, Kulseng B, Chen D.
PLOS ONE 2013 September 9 PMID: 24039816

Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding
Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL and Brüning JC.
Cell 2014 January 30 PMID: 24462248
2013

Tanycyte-Like Cells Form a Blood–Cerebrospinal Fluid Barrier in the Circumventricular Organs of the Mouse Brain.
Fanny Langlet, Amandine Mullier, Sebastien G. Bouret, Vincent Prevot, and Benedicte Dehouck.
J Comp Neurol. 2013 October 15; 521(15): 3389–3405. doi:10.1002/cne.23355. PMID: 23649873

Hypothalamic j-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin
Amparo Romero-Picó, Maria J Vázquez, David González-Touceda, Cintia Folgueira, Karolina P Skibicka, Mayte Alvarez-Crespo, Margriet A Van Gestel, Douglas A Velásquez, Christoph Schwarzer, Herbert Herzog, Miguel López, Roger A Adan, Suzanne L Dickson, Carlos Diéguez and Rubén Nogueiras.
Neuropsychopharmacology (2013) 38, 1296–1307 doi:10.1038/npp.2013.28;
PMID:23348063

Comparison of Postprandial Profiles of Ghrelin, Active GLP-1, and Total PYY to Meals Varying in Fat and Carbohydrate and Their Association With Hunger and the Phases of Satiety
Catherine Gibbons, Phillipa Caudwell, Graham Finlayson, Dominic-Luc Webb, Per M. Hellström, Erik Näslund, and John E. Blundell.
J Clin Endocrinol Metab, May 2013, 98(5):E847–E855 doi: 10.1210/jc.2012-3835 PMID: 23509106

Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor
Eleftheria Diakogiannaki, Ramona Pais, Gwen Tolhurst, Helen E. Parker, James Horscroft, Beate Rausche,Tamara Zietek, Hannelore Daniel,Fiona M. Gribble & Frank Reimann

Diabetologia (2013) 56:2688–2696 doi: 10.1007/s00125-013-3037-3
PMID:24045836

Divergent circuitry underlying food reward and intake effects of ghrelin: Dopaminergic VTA-accumbens projection mediates ghrelin’s effect on food reward but not food intake
Karolina P. Skibicka, Rozita H. Shirazi, Cristina Rabasa-Papio, Mayte Alvarez-Crespo, Corinna Neuber, Heike Vogel, Suzanne L. Dickson.
Neuropharmacology 73 (2013) 274-283 doi:10.1016/j.neuropharm.2013.06.004
PMID:23770258

Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6
Shirazi R, Palsdottir V, Collander J, Anesten F, Vogel H, Langlet F, Jaschke A, Schürmann A, Prévot V, Shao R, Jansson JO, Skibicka KP

PNAS 2013 Sep 18 [Epub ahead of print] PMID 24048027

The gut microbiota reduces leptin sensitivity and the expression of the obesity suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous system
Schéle E, Grahnemo L, Anesten F, Hallén A, Bäckhed F, Jansson JO
Endocrinology 2013 Jul 26 [Epub ahead of print] PMID 23892476

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting
Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P, Bouret SG, Prevot V, Dehouck B.
Cell Metabolism 17 (4) 2013 Apr 02 PMID 23562080

Role for the obesity-related FTO gene in the cellular sensing of amino acids
Gulati P, Cheung MK, Antrobus R, Church C, Harding HP, Tung YCL, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GSH
PNAS 2012 Dec 28 [Epub ahead of print] PMID 23359686

Protein leverage affects energy intake of high-protein diets in humans
Martens EA, Lemmens SG, Westerterp-Plantenga Ms
Am J Clin Nutr 2013 Jan [Epub ahead of print] PMID 23221572
2012

A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.
Egerod KL, Engelstoft MS, Grunddal KV, Nøhr MK, Secher A, Sakata I, Pedersen J, Windeløv JA, Füchtbauer EM, Olsen J, Sundler F, Christensen JP, Wierup N, Olsen JV, Holst JJ, Zigman JM, Poulsen SS, Schwartz TW.
Endocrinology. 2012 Dec; 153(12):5782-95. doi: 10.1210/en.2012-1595. Epub 2012 Oct 12.
PMID: 23064014

Arcuate nucleus homeostatic systems are not altered immediately prior to the scheduled consumption of large, binge-type meals of palatable solid or liquid diet in rats and mice
Bake T, Duncan JS, Morgan DG, Mercer JG
Journal of Neuroendocrinology 2012 Nov 29 [Epub ahead of print] PMID 23194408

Resting metabolic rate is associated with hunger, self-determined meal size, and daily energy intake and may represent a marker for appetite
Caudwell P, Finlayson G, Gibbons C, Hopkins M, King N, Naslund E, Blundell JE
The American Journal of Clinical Nutrition 2012 Nov 28 [Epub ahead of print] PMID 23193010
A possible association between panic disorder and a polymorphism in the preproghrelin gene
Hansson C, Annerbrink K, Nilsson S, Bah J, Olsson M, Allgulander C, Andersch S, Sjoedin I, Eriksson E, Dickson SL
Psychiatry Research 2012 Oct 17 [Epub ahead of print] PMID 23084284
Food cues and ghrelin recruit the same neuronal circuitry
van der Plasse G, Merkestein M, Luijendijk MCM, van der Roest M, Westenberg HGM, Mulder AB, Adan RAH
International Journal of Obesity 2012 Oct 16 [Epub ahead of print] PMID 23069665
The amygdala as a neurobiological target for ghrelin in rats: neuroanatomical, electrophysiological and behavioral evidence
Alvarez-Crespo M, Skibicka KP, Farkas I, Molnar CS, Egecioglu E, Hrabovszky E, Liposits Z, Dickson SL
PLOS ONE 2012 Oct 10 PMID 23071554
Eating Behavior and GLP-1-Producing Cells in Interposed Ileum and Pancreatic Islets in Rats Subjected to Ileal Interposition Associated with Sleeve Gastrectomy
Johannessen H, Kodama Y, Zhao CM, Sousa MML, Slupphaug G, Kulseng B, Chen D
Obesity Surgery 2012 Sep 05 [Epub ahead of print] PMID 22949011
Contribution of the mesolimbic dopamine system in mediating the effects of leptin and ghrelin on feeding.
R. van Zessen, G. van der Plasse and R. A. H. Adan
Proc. Nut. Soc. (2012) 71: 435–445 doi:10.1017/S0029665112000614 PMID: 22800867
Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive functio.
Caron E, Ciofi P, Prévot V, Bouret SG
Journal of Neuroscience 32 (33), 2012 Aug 15 PMID 22895731
Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry
Habib AM, Richards P, Cairns LS, Rogers GJ, Bannon CA, Parker HE, Morley TC, Yeo GS, Reimann F, Gribble FM
Endocrinology 2012 Jun 08 [Epub ahead of print] PMID 22685263
Embryonic birthdate of hypothalamic leptin-activated neurons in mice
Ishii Y and Bouret SG
Endocrinology 2012 May 23 [Epub ahead of print] PMID 22621961
FTO expression is regulated by availability of essential amino acids
Cheung MK, Gulati P, O'Rahilly S, Yeo GS
Int J Obes 2012 May 22 [Epub ahead of print] PMID 22614055
Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function
Caron E, Ciofi P, Prevot V, Bouret SG
J Neurosci 2012 May 15 32 (33) PMID 22895731
The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors
Dickson SL, Shirazi RH, Hansson C, Bergquist F, Nissbrandt H, Skibicka KP
The Journal of Neuroscience 32 (14), 2012 Apr 04 PMID 22492036
Kinetic analysis of FTO (Fat mass and obesity related) reveals that it is unlikely to function as a sensor for 2-oxoglutarate
Ma M, Harding HP, O’Rahilly S, Ron D and Yeo GS
BJ Metabolism 444 (2), 2012 Mar [Epub ahead of print] PMID 22435707
Interleukin-6 Receptor α is Co-localised with Melanin-Concentrating Hormone in Human and Mouse Hypothalamus
Schéle E, Fekete C, Egri P, Füzesi T, Palkovits M, Keller E, Liposits Z, Gereben B, Karlsson-Lindahl L, Shao R, Jansson JO
J Neuroendocrinol, 2012 February [Accepted article ahead of print] PMID 22295972
Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation
Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG
Cell Metabolism 15, 2012 February 08 [Epub ahead of print] PMID 22285542

Ghrelin Mediates Anticipation to a Palatable Meal in Rats
Merkestein M, Brans MA, Luijendijk MC, de Jong JW, Egecioglu E, Dickson SL, Adan RA
Obesity, 2012 January 26 [Epub ahead of print] PMID 22282050
2011

Ghrelin Interacts with Neuropeptide Y Y1 and Opioid Receptors to Increase Food Reward
Skibicka KP, Shirazi RH, Hansson C, Dickson SL
Endocrinology 153, 2011 December 30 [Epub ahead of print] PMID 22210742

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2.
Tolhurst G, Heffron H, Lam YS, Parker HE, Habib AM, Diakogiannaki E, Cameron J, Grosse J, Reimann F, Gribble FM
Diabetes, 2011 December [Epub ahead of print] PMID 22190648
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, Brüning JC
Nat Neurosci 14, 2011 June 05 PMID 21642975

Cajal revisited: does the VMH make us fat?
Yi CX, Scherer T & Tschöp MH
Nat Neurosci 14, 2011 June 05 PMID 21709675.1

Ghrelin directly targets the ventral tegmental area to increase food motivation
Skibicka KP, Hansson C, Alvarez-Crespo M, Friberg PA, Dickson SL
Neuroscience 180, 2011 April 28 [Epub ahead of print] PMID 21335062
Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in mice
Lager S, Asterholm IW, Schéle E, Jansson N, Nilsson S, Jansson JO, Lönn M, Holmäng A.
Endocrinol 152 (4), April 2011 [Epub ahead of print] PMID 21285312

 

Review Articles
2016

EU Research Report - Full4Health: Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health.
Amin T and Mercer JG.
Nutrition Bulletin 2016 March Vol 41: Issue 1, pages 87–91. DOI: 10.1111/nbu.12193

Hunger and satiety mechanisms and their potential exploitation in the regulation of food intake.
Amin T and Mercer JG.
Current Obesity Reports (in press) 2016 March DOI 10.1007/s13679-015-0184-5
PMID: 26762623
2015

Obesity Impairs the Action of the Neuroendocrine Ghrelin System.
Zigman JM, Bouret SG, Andrews ZB.
Trends Endocrinol Metab. 2015 Nov 2. pii: S1043-2760(15)00193-9. doi: 10.1016/j.tem.2015.09.010. [Epub ahead of print]
PMID: 26542050

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium.
Gribble FM, Reimann F.
Annu Rev Physiol. 2015 Oct 6. [Epub ahead of print]
PMID: 26442437

The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones.
Meek CL, Lewis HB, Reimann F, Gribble FM, Park AJ.
Peptides. 2015 Sep 5. pii: S0196-9781(15)00245-4. doi: 10.1016/j.peptides.2015.08.013. [Epub ahead of print]
PMID: 26344355

Regulation of gut hormone secretion. Studies using isolated perfused intestines.
Svendsen B, Holst JJ
Peptides. 2015 Aug 11. pii: S0196-9781(15)00221-1. doi: 10.1016/j.peptides.2015.08.001. [Epub ahead of print]
PMID: 26275337

Hypothalamic inflammation and food intake regulation during chronic illness. Dwarkasing JT, Marks DL, Witkamp RF, van Norren K.
Peptides. 2015 Jul 6. pii: S0196-9781(15)00194-1. doi: 10.1016/j.peptides.2015.06.011. [Epub ahead of print]
PMID: 26158772

Brain IL-6--Where Amylin and GLP-1 Antiobesity Signaling Congregate.
Jansson JO, Palsdottir V.
Diabetes. 2015 May;64(5):1498-9. doi: 10.2337/db14-1910.
PMID: 25908873

Regulation of body fat mass by the gut microbiota: Possible mediation by the brain.
Schéle E, Grahnemo L, Anesten F, Hallén A, Bäckhed F, Jansson JO.
Peptides. 2015 Apr 28. pii: S0196-9781(15)00094-7. doi: 10.1016/j.peptides.2015.03.027. [Epub ahead of print]
PMID: 25934163

Gut chemosensing mechanisms.
Psichas A, Reimann F, Gribble FM.
J Clin Invest. 2015 Mar 2;125(3):908-17. doi: 10.1172/JCI76309. Epub 2015 Feb 9.
PMID: 25664852

Hunger and Satiety. Food Science and Technology March 2015.
Amin T and Mercer JG.

Protein diets, body weight loss and weight maintenance.
Martens EA, Westerterp-Plantenga MS.
Curr Opin Clin Nutr Metab Care 2014;17:75-9. doi: 10.1097/MCO.0000000000000006 PMID: 24310056

Approaches to influencing food choice across the age groups: from children to the elderly.
Mercer JG, Johnstone AM, Halford JC.
Proc Nutr Soc. 2015 Jan 19:1-9. (Epub ahead of print). Doi: 17/S0029665114001712
PMID: 25598432

Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity
Bouret SG, Levin BE, Ozanne SE.
Physiological Reviews, 95(1):47-82, 2015. doi: 10.1152/physrev.00007.2014
PMID: 25540138

Appetite control and energy balance: impact of exercise
Blundell J, Gibbons C, Caudwell P, Finlayson G, Hopkins M.
Obesity Reviews 2015; 16(S1): 67-76. doi: 10.1111/obr.12257
PMID: 25614205
2014

Exercise and weight loss: No sex differences in body weight response to exercise.
Caudwell P, Gibbons C, Finlayson G, Näslund E, Blundell J.
Exercise and sport sciences reviews 2014; 42(3): 92-101. doi: 10.1249/JES.0000000000000019
PMID: 24949844

Ghrelin signaling on food reward: a salient link between the gut and the mesolimbic system.
Mario Perello and Suzanne L Dickson
Journal of Neuroendocrinology (2014) doi: 10.1111/jne.12236
PMID: 25377898
2013

Enteroendocrine hormones - central effects on behaviour   
Karolina P Skibicka and Suzanne L Dickson
Current Opinion in Pharmacology 2013, 13:977–982
PMID: 24091195

The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis
Anthony P Coll and Giles SH Yeo
Current Opinion in Pharmacology 2013, 13:970–976
PMID: 24075719

The biology of FTO: from nucleic acid demethylase to amino acid sensor
Pawan Gulati & Giles S. H. Yeo
Diabetologia (2013) 56:2113–2121
PMID: 23896822

Development of the hypothalamic melanocortin system
Berengere Coupe and Sebastien G. Bouret      
Frontiers in Endocrinology March 2013, Volume 4  Article 38
PMID: 23543895

Ghrelin, reward and motivation
Menzies JR, Skibicka KP, Leng G, Dickson SL
Endocr Dev 25, 2013.
PMID 23652396

EU Obesity Research Explores Food-Gut-Brain Mechanisms
Wagner G et al.
Food Technology 11 Mar 2013. IFT

Organizational actions of metabolic hormones
Bouret SG
Frontiers in Neuroendocrinology 34 (1), 25 Jan 2013 , pages 18-26.
PMID 23357643
2012

Uncovering the biology of FTO
Giles S.H.Yeo, Stephen O’Rahilly
Molecular Metabolism 1 (2012) 32–36
PMID: 24024116

Mechanisms underlying current and future anti-obesity drugs
Adan R
TINS Review 2012 [Epub ahead of print]
PMID 23312373

Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation
Blundell JE et al.
Disease Models & Mechanisms 5 (5), 2012.
PMID 22915022

My brain made me do it, and my gut didn't help
Menzies J
Journal of Neuroendocrinology 24, 2012.
PMID 22897412

Food-induced brain responses and eating behaviour
Smeets PAM, Charbonnier L, van Meer F, van der Laan LN, Spetter MS
Proceedings of the Nutrition Society, 2012.
PMID 22931854

The gut endocrine system as a coordinator of postprandial nutrient homoeostasis
Gribble F
Proceedings of the Nutrition Society, 2012.
PMID 22906726

Contribution of the mesolimbic dopamine system in mediating the effects of leptin and ghrelin on feeding
van Zessen R , van der Plasse G and Adan RAH
Proceedings of the Nutrition Society, 2012.
PMID 22800867

Peripheral Signals Modifying Food Reward
Menzies JRW, Skibicka KP, Egecioglu E, Leng G, Dickson SL
Handbook of Experimental Pharmacology 209, 2012, pages 131-58.
PMID 22249813
2011

Developmental effects of ghrelin
Steculorum SM, Bouret SG
Peptides 32 (11, Special Issue on Ghrelin), November 2011, pages 2362-2366.
PMID 21736909

The role of the central ghrelin system in reward from food and chemical drugs
Dickson SL, Egecioglu E, Landgren S, Skibicka KP, Engel JA, Jerlhag E
Molecular and Cellular Endocrinology 340 (1), 20 June 2011, pages 80–87.
PMID: 21354264

Ghrelin and food reward: the story of potential underlying substrates.
Skibicka KP, Dickson SL
Peptides 32 (11), November 2011, pages 2265–2273.
PMID 21621573

Unraveling the brain regulation of appetite: lessons from genetics
Yeo GS and Heisler LK
Nature Neuroscience 15 (10), 25 Sep 2012, pages 1343-9.
PMID 23007189

Hedonic and incentive signals for body weight control:
Egecioglu E, Skibicka KP, Hansson C, Alvarez-Crespo M, Friberg PA, Jerlhag E, Engel JA, Dickson SL
Rev Endocr Metab Disord. 12 (3), Sep 2011; pages 141-51.
PMID 21340584
Research Briefs

2014

2013

2012

Abstracts

Presented at the Digestive Disease Week in Florida 2012

Presented in October 2011 at the 11th European Nutrition Conference FENS Madrid 2011

Presentations

Symposia

Developmental programming of the hypothalamus by ghrelin.
Bouret SG
Symposium, Endocrine Society of Australia & Australasian Paediatric Endocrine Group Annual Meeting, August 2011

Hormonal programming of hypothalamic development.
Bouret SG
Symposium. New Zealand Queenstown Research Week Meetings, Symposium on Epigenetics and Development, Otago, New Zealand, August 2011

Gut feelings: how the gut controls brain functioning.
Bouret SG
Keynote Lecture. 9th Dutch Endo-Neuro-Psycho Meeting, Lunteren, The Netherlands, June 2011

Development of appetite-regulating brain centers.
Bouret SG
Symposium on Eating Disorders, Handaye, France, June 2011

Effects of leptin and ghrelin on the development of the hypothalamus.
Bouret SG
Symposium. The European Association for the Study of Obesity Björntorp Symposium, Gothenburg, Sweden, June 2011

Leptin and neuronal development.
Bouret SG
Symposium. 18th European Congress on Obesity, Istanbul, Turkey, May 2011

Leptin, nutrition, and the programming of hypothalamic feeding circuits.
Bouret SG
Symposium. Metabolism, Nutrition, and the Brain Symposium, Groningen, The Netherlands, May 2011

Seminars

Hormonal regulation of hypothalamic development.
Bouret SG
Seminar. University of Cincinnati, Neuroscience Program, Cincinnati, OH, USA, April 2011