Eating a high fat diet can impair the function of the part of the brain that controls appetite and energy expenditure which in turn dictates our weight. That is the finding shared today (Friday, September 7) at the British Science Festival by scientists at the University of Aberdeen Rowett Institute for Nutrition and Health.
This may help explain why overweight people struggle to lose weight and then struggle to maintain their weight loss.
Researchers fed mice a diet high in saturated fat and sugar over 16 weeks - where 60% of their energy came from saturated fat - and compared them with mice fed a normal diet over the same period.
Using techniques such as transcriptomics and proteomics, scientists then studied genes and proteins in the hypothalamus of their brain – the part that regulates eating and energy expenditure.
They found that mice fed a high fat diet had changes to genes and proteins indicative of damage in the hypothalamus and that these changes occurred very rapidly - within weeks.
Dr Lynda Williams, Obesity and Metabolic Health Group Leader, at the Rowett, said: “The hypothalamus is a small area at the base of the brain containing neurones that control the amount of food we eat and the energy we expend.
“However this control breaks down in obesity – the system appears not to work – and we don’t really know why this happens. In our study we found that genes and proteins changed in response to a high fat diet and that these changes are normally associated with damage in the brain, indicating that damage had occurred in the hypothalamus in mice that ate a diet high in saturated fat.
“We instinctively know that eating a diet high in saturated fat and sugar will lead to overweight and obesity. Our results indicate that a high fat diet can damage the areas of the brain that control energy balance and perpetuate the development of obesity. High fat and high sugar foods are energy dense foods which are highly palatable and they are very easy to overeat .Our findings may also explain why some overweight people find it difficult to diet and why weight loss after dieting is so difficult to maintain. We now plan to carry out further studies that will look at whether these effects are reversible.”
Browse by Month
- Jan There are no items for January 2011
- Mar There are no items for March 2011
- Apr There are no items for April 2011
- Jun There are no items for June 2011
- Jul There are no items for July 2011
- Oct There are no items for October 2011
- Nov There are no items for November 2011
- Dec There are no items for December 2011
- Jan There are no items for January 2010
- Feb There are no items for February 2010
- Mar There are no items for March 2010
- Apr There are no items for April 2010
- May There are no items for May 2010
- Jun There are no items for June 2010
- Jul There are no items for July 2010
- Aug There are no items for August 2010
- Sep There are no items for September 2010
- Oct There are no items for October 2010
- Nov There are no items for November 2010