The role of vasopressin in the development of hypertension
The mechanisms that underpin the development of hypertension remain to be fully explained, in part, due to limitations of established animal models of hypertension. We have used genetically-modified Cyp1a1-Ren2 rats in which the onset and severity of angiotensin II-dependent hypertension is controlled by dietary administration of indole-3-carbinol, to show that vasopressin secretion exacerbates the increase in blood pressure evident early in the development hypertension. This increased vasopressin secretion results from blunted baroreflex inhibition of vasopressin neurons, which is underpinned by an excitatory shift in their response to endogenous GABA signalling.
- Prof Colin Brown
- Hosted by
- Rowett Institute
- The Rowett Institute
Dr Nigel Hoggard
Tel: 01224 438655
This is a technical seminar aimed at professional scientists. If you are not a University of Aberdeen staff member and would like to attend, please contact us.