Research Fellow (Human Chromosome Maintenance), Medicine, Medical Sciences & Nutrition (IMS208RXY)

We seek a Research Fellow to work on mechanisms of mammalian chromosome maintenance in the laboratory of Professor Anne Donaldson & Dr Shin-ichiro Hiraga.  The successful candidate will join a well-funded, dynamic research team within an interactive and growing group of laboratories sharing an interest in chromosome biology.

School/Section: Medicine, Medical Sciences & Nutrition
Division: Institute of Medical Sciences
Staff Category: Research
Position Type: Full Time
Grade: Grade 6
Salary: £34,304 - £37,467
Ref No: IMS208RXY
Closing Date: 16-SEP-2022


Job Description

The researcher appointed will examine how the human RIF1 protein acts during DNA replication to ensure correct chromosome maintenance, taking forward recent unpublished breakthroughs concerning how RIF1 regulates DNA replication, the cellular components it targets, and whether RIF1 acts through a similar molecular mechanism in its various cellular functions.  Our current analyses have provided new insight into how RIF1 is recruited to sites of replication, providing a timely and unique opportunity to understand this key regulator of fundamental genome maintenance mechanisms.  The position would particularly suit a postdoctoral researcher interested in combining molecular, biochemical, cellular, and genomic approaches to address fundamental cellular processes.  Applicants with prior experience in analysis of chromosome maintenance, DNA replication, genome stability, and/or cytological studies of genome maintenance are particularly welcome.

We are seeking a well-motivated, enthusiastic individual with a demonstrated interest in the field of chromosome maintenance.  You should have (or be about to obtain) a PhD in Molecular Biology or a related field, or an MSc plus the appropriate level of experience demonstrating the required skills and capabilities.  Experience in one or more of the following area(s) will be an advantage: mammalian cell genome stability analyses, CRISPR genomic engineering, proteomic analysis, protein expression and purification, chromatin analysis methods (e.g. chromosome fibre analysis, ChIP and related techniques), and functional assays for chromosome stability (e.g. DNA repair and/or replication assays). 

Salary will be at the appropriate point on the Grade 6 salary scale (£34,304 - £37,467 per annum) and negotiable with placement according to qualifications and experience.

As this post is externally funded by Cancer Research UK it is available for 36 months in the first instance.

Any appointment will be made subject to satisfactory references and a 12 month probation period.

For further information on various staff benefits and policies please visit

Should you require a visa to undertake employment in the UK you will be required to fulfil the minimum points criteria to be granted a Certificate of Sponsorship under the requirements of the Skilled Worker visa.  At the time an offer of appointment is made, you will be asked to demonstrate that you fulfil the criteria in respect of qualification and competency in English. For research and academic posts, we will consider eligibility under the Global Talent visa. Please do not hesitate to contact Natalie Reid, HR Adviser (e-mail: for further information.   

This role is based in the UK and as such the successful candidate will be required to live and work in the UK.

Informal enquiries are welcome, please contact Professor Anne Donaldson ( or

Dr Shin-ichiro Hiraga (

Please quote reference number IMS208RXY on all correspondence

The closing date for the receipt of applications is 16 September 2022

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