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MT5029: TOXICOLOGY (2019-2020)

Last modified: 25 Sep 2019 09:58


Course Overview

This course provides advanced level learning in drug metabolism, discovery and development.  It includes the importance of drug transporters in the drug discovery process, regulatory issues and  molecular toxicology and pharmacology at an advanced level. Mechanisms of drug-induced and oxidative stress and immunopharmacology are described. External experts are invited to provide their unique expertise on a range of topics which can include toxicopathology, immunotoxicology, risk assessment and an industrial perspective on the drug discovery process.



Course Details

Study Type Postgraduate Level 5
Session First Sub Session Credit Points 15 credits (7.5 ECTS credits)
Campus Aberdeen Sustained Study No
Co-ordinators
  • Professor Heather Wallace

What courses & programmes must have been taken before this course?

  • Any Postgraduate Programme (Studied)

What other courses must be taken with this course?

None.

What courses cannot be taken with this course?

Are there a limited number of places available?

No

Course Description

Topics - absorption, distribution, metabolism, excretion and transport of drugs. Human drug metabolism -cytochrome P450. Induction/inhibition of cytochrome P450. Identification of
cytochrome P450 and transporters at an early stage in drug discovery. Mechanisms of drug induced toxicity: reactive metabolites; cytoprotective mechanisms; agents conferring
protection against drug toxicity - clinical applications; mechanisms of cell death; apoptosis and necrosis. Immunotoxicology and risk assessment. Pathology of drug toxicity. Haematological indices of drug toxicity.




In light of Covid-19 this information is indicative and may be subject to change.

Contact Teaching Time

Information on contact teaching time is available from the course guide.

Teaching Breakdown

  • 1 Science Laboratory during University week12
  • 1 Lecture during University weeks 8 - 9, 16
  • 2 Lectures during University weeks 10 - 15, 17
  • 1 Practical during University week16

More Information about Week Numbers


In light of Covid-19 and the move to blended learning delivery the assessment information advertised for second half-session courses may be subject to change. All updates for second-half session courses will be actioned in advance of the second half-session teaching starting. Please check back regularly for updates.

Summative Assessments

Exam

Assessment Type Summative Weighting 50
Assessment Weeks Feedback Weeks

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Learning Outcomes
Knowledge LevelThinking SkillOutcome
Sorry, we don't have this information available just now. Please check the course guide on MyAberdeen or with the Course Coordinator

Lab Report: Individual

Assessment Type Summative Weighting 20
Assessment Weeks 17 Feedback Weeks 19

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Learning Outcomes
Knowledge LevelThinking SkillOutcome
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Debate (group)

Assessment Type Summative Weighting 15
Assessment Weeks 17 Feedback Weeks 18

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Learning Outcomes
Knowledge LevelThinking SkillOutcome
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Editorial

Assessment Type Summative Weighting 15
Assessment Weeks 14 Feedback Weeks 16

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Learning Outcomes
Knowledge LevelThinking SkillOutcome
Sorry, we don't have this information available just now. Please check the course guide on MyAberdeen or with the Course Coordinator

Formative Assessment

There are no assessments for this course.

Course Learning Outcomes

Knowledge LevelThinking SkillOutcome
ProceduralEvaluateDiscuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies
ProceduralUnderstandUnderstand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity
ConceptualEvaluateDescribe various types of biomarkers particularly in relation to cancer and cancer therapies
ReflectionEvaluateEvaluating industrial drug research and development and risk assessment
ReflectionCreateimproved scientific communication

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