Office A107, Institute of Dentistry
Office 3:47 / 08 Institute of Medical Sciences
Lab 4:51 Institute of Medical Sciences
Aberdeen, AB25 2ZD
I qualified as a dentist in 2001 (University of Jordan). During my years of study, I developed a keen interest in Oral Pathology, and in particular in the pathology of malignant and premalignant oral lesions. I therefore joined a postgraduate research program in Oral Pathology at the University of Birmingham, England. The focus of my research was the quantification of oral cancer and pre-cancer growth patterns using digital imaging. I successfully completed my PhD in 2005, and worked as a Research fellow in the same institute.
In 2006, I joined the academic staff at the Faculty of Dentistry at the University of Jordan as an Assistant Professor in Oral Pathology.
In 2009 I joined the Academic staff of the newly established Dental School at the University of Aberdeen.
During my time in Aberdeen, I studied for my PGCert in Higher Education Teaching and Learning, and I completed the course in July 2011 and became a fellow of the Higher Education Academy.
In 2011, I was successful in securing a prestigious research fellowship from the King Hussein Institute for Biotechnology and Cancer to conduct state of the art research in the field of cancer immunology in USA. My fellowship was split between the National Cancer Institute/ National Institutes of Health and Georgia Regents University (Currently Augusta University), where I later became an Assistant Research Scientist. The focus of our research group was T cell Biology and the modulation of the immune system as part of cancer immune therapy.
In October 2016, I re-joined the Academic staff at the University of Aberdeen Dental School as a Senior Lecturer in Oral Sciences. My primary research focus is T cell biology, head and neck cancer immunology in addition to applications of digital pathology.
- PhD Dentistry (Oral Pathology)2005 - University of BirminghamThesis title: Analysis and Quantification of Oral Cancer and Precancer growth patterns
- PGCert Higher Education Learning and Teaching2011 - University of AberdeenDissertation title: Tooth Model Carving as a Method for Teaching Tooth Morphology
- BDS Dentistry2001 - University of Jordan
Memberships and Affiliations
- Internal Memberships
- Postgraduate Research Coordinator at the Institute of Dentistry (December 2017- current date)
- Chair of the Postgraduate Student Liaison Group at the School of Medicine, Medical Sciences & Nutrition (April 2019-current date)
- Academic lead for Oral Biology at the Instiute of Dentistry (July 2019-current date)
- Member of the Curriculum Management Committee at the Institute of Dentistry (July 2019-current date)
- Lead Cancer Research Group at the Institute of Dentistry
- Member of the Research Committee at the Institute of Dentistry (October 2016-current date)
- Member of the Postgraduate Research Management Group at the School of Medicine, Medical Sciences & Nutrition (December 2017- current date)
- Member of the School of Medicine, Medical Sciences and Nutrition Industrial Liaison Committee (November 2018-current date)
- Chair of the Research Committee at the Institute of Dentistry (April 2018- January 2020)
- Member of the Executive Committee at the Institute of Dentistry (April 2018- January 2020)
- Member of the PGR Marketing working group at the School of Medicine, Medical Sciences & Nutrition (February 2021-current date)
- Member of the Ethical Review Board sub committee at the School of Medicine, Medical Sciences & Nutrition (February 2021-current date)
- External Memberships
- Fellow of the Academy of Higher Education, UK (July 2011 till current date)
- British Society for Immunology
- Scottish Society of Cytomics
- The Association of Science Educators in Dentistry (ASEiD), formerly the Association of Basic Science Teachers in Dentistry (ABSTD)
- British Society of Oral Medicine
- Pathological Society
My main research interests are in digital pathology and cancer immunology and immunotherapy in different cancer types.
I have a special focus on various aspects of head and neck cancer. This includes the objective diagnosis and quantification of oral premalignant and malignant lesions using digital pathology in addition to cancer immunology and immune therapy.
I am currently accepting PhDs in Biomedical Sciences, Dentistry.
Please get in touch if you would like to discuss your research ideas further.
Morphological and Immunological Characterization of HPV Positive Head and Neck Cancer and Pre-cancer
(Funded by Friends of Anchor, NHS Endowment)
The incidence of head and neck cancer (HNC) has increased in UK both in males and females and is still on the rise with the highest rates reported in Scotland. This increase is attributed to changes in risk factors such as alcohol and tobacco consumption in addition to human papilloma virus (HPV) infections. HPV infection affects younger age groups and is therefore associated with HNC and premalignant lesion diagnoses at younger ages than traditionally reported.
Premalignant lesions predispose to malignant transformation and should be monitored to aid in the early detection of malignant transformation. Classically, premalignant lesions were classified into mild, moderate and severe epithelial dysplasia. This classification system suffered from subjectivity leading to noticeable discrepancies in inter-and intra-examiner consistency in diagnosing these lesions. Therefore, there is a move towards simpler more reproducible classification systems that divide premalignant lesions into low and high grades.
To aid the classification dilemma and ultimately improve the ability to predict malignant changes, several studies were performed that applied reproducible and objective parameters to analyse tissue sections from different pathological entities. Our group used morphological features such as the complexity of the epithelial connective tissue interface (ECTI), and descriptors of cell shape and size to characterize oral cancer and precancer in addition to normal oral mucosa (Abu Eid and Landini, 2003; 2005). It is hoped that such criteria can be implemented in the design of new classification systems that will better predict malignant transformation potential and provide guidelines for clinical management.
Despite advances in treating HNC, the mortality rate is still high which is mainly due to the late diagnosis of these cases. Therefore, there is great need for developing diagnostic tools that aid in early detection. Additionally, the development of novel therapies is essential. Among the advances in cancer treatment, cancer immunotherapy is one of the most important developments. HNCs positive for HPV are candidates for cancer immunotherapy. Our group has reported promising anti-tumour efficacy in TC-1 murine mouse model, which expresses HPV E7 using different formulations of HPV E7 peptide vaccines, including different adjuvants (Abu Eid et al., 2014) and listeria based E7 vaccine (Mkrtichyan et al., 2014). The anti-tumour therapeutic efficacy of these vaccines was significantly enhanced when combined with PI3k/Akt pathway inhibitors (Abu Eid et al., 2014; 2017; Ahmad et al. 2017). Furthermore, in cervical cancer patients, we showed that Pre-Immature Dendritic Cells pulsed with HPV E7 are capable of inducing specific immune responses against the E7 peptide despite the advanced disease (Rahma et al., 2014). We further showed that combining HPV E7 vaccines with antibodies targeting PD-1 enhance anti-tumour therapeutic efficacy through modulating the tumour microenvironment (Mkrtichyan et al., 2014). It is therefore integral to understand the role of PD-1 and its ligands (PDL-1 and PDL-2) in HNC (Shrimali et al., 2015).
To further the research into HNC immunotherapy and the classification of premalignant lesions, full understanding of the immune response in addition to complete characterization of morphological changes in HPV positive and negative premalignant and malignant lesions is crucial.
Modulators of T Cell Function
Collaboration with Dr Frank Ward, University of Aberdeen
(Funded by Friends of Anchor)
Cancer immunotherapy is among the most important developments in cancer treatment. Despite its impressive successes, the response in patients is often limited and short lived. This is due to factors that hamper the immune response against tumour cells.
Regulatory CD4 T-cells (Tregs) are major contributors to the suppressive tumour microenvironments and immune modulators that selectively mitigate these cells are needed.
The expression of co-inhibitory molecules by tumour cells is another tumour mediated immune escape mechanism that leads to the suppression of effector T-cells. Immune checkpoint inhibitors that block the interaction between these co-inhibitory molecules and their receptors have shown remarkable results in enhancing anti-tumour therapeutic efficacy.
Additionally, cancer immunotherapy is hindered by the short-lived anti-tumour effect due to the exhaustion of tumour-specific effector CD8 T-cells. The phenotype and differentiation status of CD8 T-cells have major influences on their function. There is intense interest in manipulating immune modulators to maximise their cytotoxicity and enhance their longevity as part of cancer immunotherapy.
Small molecule inhibitors that target different signalling pathways within T cells have been used successfully to modulate T-cell responses by selectively inhibiting Tregs and/or generating superior antigen-specific CD8 T-cells with enhanced proliferative ability, survival and functional capability (Abu Eid et al. 2014, 2015, 2016, 2017). Furthermore, immune checkpoint inhibitors have proven successful in modulating the anti-tumour immune response.
The aim of our work is to identify targets for selective modulation of immune cells while understanding the specific mechanisms that control T cell development and responses. Results will guide combination therapies with different immune modulators as part of cancer treatment.
The Effect of Oligohydramnios on Tissue and Cellular Morphometry in the Developing Foetal Murine Lung.
Collaboration with Dr Tanbir Najrana and Dr Juan Esteban-Sanchez, the Department of Paediatrics, Alpert Medical School of Brown University. Women & Infants Hospital of Rhode Island, USA
(Funded by the National Institute of General Medical Sciences of the National Institutes of Health Department of Pediatrics; Kilguss Research Core of Women & Infants Hospital of Rhode Island).
Oligohydramnios resulting from membrane ruptures can cause pulmonary hypoplasia in humans. This has been confirmed experimentally in different animal models and attributed to the decrease in lung distention as result of a decrease in lung fluid in the developing air spaces.
We have characterized a mouse model of pulmonary hypoplasia secondary to severe oligohydramnios and reported significant changes in the differentiation of different cell types, in particular Type I cells, where the level of T1-α (a marker for Type I cells) was significantly reduced in OH both at the mRNA and protein levels. Furthermore, we found that oligohydramnios affects vasculogenesis and apoptosis without altering cell proliferation. Interestingly, we reported a major decrease in developing lung spaces and a significant decrease in cell size and a change in cell shape as a result of oligohydramnios using different descriptors of particle size and shape (Najrana et al., 2016; 2017).
Currently, we are looking into different rescue models for foetal pulmonary hypoplasia using different murine models.
Fractals in Biology and Medicine. Pecha Kucha Talk. Explorathon 17, Aberdeen, September 2017.
- Shaymaa Mohammed, Institute of Dentistry, University of Aberdeen. Start Date October 2021.
Funded by a Scholarship from Hamad Medical Corporation, Qatar
Project: The applications of tele- and audio-dentistry in patient care and dental education
Role: Lead supervisor
- Sreedevi Unnikrishnan, Institute of Dentistry, University of Aberdeen. Start Date February 2021. Elphinstone Scholarship.
Project: Clinical and molecular correlates of response to first line treatment in oral lichen planus
- Subarnarekha Chatterji, Institute of Medical Sciences, University of Aberdeen. Start date February 2020. Elphinstone Scholarship.
Project: Understanding the biology of male breast cancer to identify more precise ways to inform clinical decision making for personalised treatment strategies.
- Katie Hanna, Institute of Medical Sciences, University of Aberdeen. Start date October 2019. Elphinstone Scholarship.
Project: Precision profiling the breast cancer microenvironment.
- Farah Alfatyan, Institute of Medical Sciences, University of Aberdeen. Start date October 2019. Elphinstone Scholarship.
Project: Analysis of intracellular sCTLA-4 and its contribution to intrinsic cell regulation
- Badri Risheh, Institute of Dentistry, University of Aberdeen. Start date October 2018. Elphinstone Scholarship.
Project: Modulators of T cell Function
Role: Lead supervisor
- Prarthna Clare, Institute of Dentistry, University of Aberdeen. Start date January 2018, submission date October 2021, pass date December 2021. Elphinstone Scholarship.
Project: Morphological and Immunological Characterisation of Head and Neck Cancer
Role: Lead supervisor
- Nadisha Piyarathne, Institute of Dentistry, University of Aberdeen. Start date January 2018, submission date June 2021, pass date July 2022. Elphinstone Scholarship.
Project: Salivary biomarkers and oral cancer risk factors.
Teaching in the BDS course
- Oral Histology (BDS2)
- Student Seminars (BDS5)
Contribution to other programs
Medical course MBChB
- Immunology of Endocrine Disease (Year 2)
- Immunology lectures (Year 3)
Immunology Honours IM4007 Course
- Immune evasion: Cancer
- Scientific paper assessment
Advanced Immunology IM4005
- Current Topics in Immunology
- Regulatory T Cells/ Tumours and Inflammatory Disease
Applied Immunology Human Health IM3502
- Immunity to viruses
Fundamentals of Immunology IM3501
- Regulatory T cells
Microbes, infection and immunity BI25M5
- Evading the immune system
MSc in Immunology and Immunotherapy
- Immunogenetics of cancer
- Assessment of student presentations
Research Tutorials Course (for masters students) MB5518
Fundamentals of Research Design Course for taught MSc Programs (FORD)
Non-course Teaching Responsibilities
- Regent as part of the regent scheme at the Institute of Dentistry
- Mentor as part of the SUCCESS scheme at the School of Medicine, Medical Sciences and Nutrition
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Disease severity scoring systems in mucosal lichen planus: a systematic reviewOral DiseasesContributions to Journals: Articles
Raman spectroscopy: current applications in breast cancer diagnosis, challenges and future prospectsBritish Journal of Cancer, vol. 126, no. 8, pp. 1125-1139Contributions to Journals: Articles
TGFb2 induces the soluble isoform of CTLA-4 – implications for CTLA-4 based checkpoint inhibitor antibodies in malignant melanomaFrontiers in Immunology, vol. 12, 763877Contributions to Journals: Articles
Targeting the PI3K/Akt/mTOR pathway: A therapeutic strategy in COVID-19 patientsImmunology Letters, vol. 240, pp. 1-8Contributions to Journals: Review articles
Proteomic analysis of a murine model of lung hypoplasia induced by oligohydramniosPediatric Pulmonology, vol. 56, no. 8, pp. 2740-2750Contributions to Journals: Articles
CTLA-4 expression by human tumor cells and its impact on immunotherapeutic strategies: a systematic reviewImmuno-Oncology Insights, vol. 2, no. 3, pp. 151-169Contributions to Journals: Review articles
Digital pathology for the identification of prognostic biomarkers in head and neck cancerImmuno-Oncology Insights, vol. 2, no. 3, pp. 123–132Contributions to Journals: Articles
Quantification of Collagen IV in normal, potentially malignant and malignant lesions of the oropharynx: A pilot studyChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors ?: A systematic reviewExpert Review of Molecular Diagnostics, vol. 21, no. 8, pp. 789-807Contributions to Journals: Articles
Morphological Assessment of Collagen IV expression in Oral Cancer and Oral Potentially Malignant Disorders: A pilot studyChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Mechanical stretch regulates the expression of specific miRNA in extracellular vesicles released from lung epithelial cellsJournal of Cellular Physiology, vol. 235, no. 11, pp. 8210-8223Contributions to Journals: Articles
Full Mouth Rehabilitation with Implant-Prosthesis in Marfan Syndrome Patient: Clinical Report and Literature ReviewJournal of Oral Implantology, vol. 46, no. 2, pp. 115-121Contributions to Journals: Articles
Editorial: Advances in Head and Neck Cancer Immunology and ImmunotherapyFrontiers in Oncology, vol. 9, 172Contributions to Journals: Editorials
Deciphering the Role of Regulatory CD4 T Cells in Oral and Oropharyngeal Cancer: A Systematic ReviewFrontiers in Oncology, vol. 8, 442Contributions to Journals: Articles
On the Road to Immunotherapy: Prospects for Treating Head and Neck Cancers With Checkpoint Inhibitor AntibodiesFrontiers in Immunology, vol. 9, 2182Contributions to Journals: Review articles
Antigen-Specific Antitumor Responses Induced by OX40 Agonist Are Enhanced by the IDO Inhibitor IndoximodCancer immunology research, vol. 6, no. 2, pp. 201-208Contributions to Journals: Articles
Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ InhibitionCancer Research, vol. 77, no. 15, pp. 4135-4145Contributions to Journals: Articles
The Effect of Oligohydramnios on Tissue and Cellular Morphometry in the Developing Fetal Murine LungChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Oligohydramnios compromises lung cells size and interferes with epithelial–endothelial developmentPediatric Pulmonology, vol. 52, no. 6, pp. 746–756Contributions to Journals: Articles
Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer ImmunotherapyCancer Research, vol. 77, no. 8, pp. 1892-1904Contributions to Journals: Articles
Old-School Chemotherapy in Immunotherapeutic Combination in Cancer, A Low-cost Drug RepurposedCancer immunology research, vol. 4, no. 5, pp. 377-382Contributions to Journals: Articles
Mutant KRAS Conversion of Conventional T Cells into Regulatory T CellsCancer immunology research, vol. 4, no. 4, pp. 354-365Contributions to Journals: Articles
Agonistic antibodies to costimulatory molecules, OX40 and GITR, significantly enhance the antitumor efficacy of Listeria monocytogenes (Lm-LLO)-based immunotherapyChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Programmed death-1 & its ligands: promising targets for cancer immunotherapyImmunotherapy, vol. 7, no. 7, pp. 777-92Contributions to Journals: Articles
Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8(+) T-cell proliferation and survivalOncoimmunology, vol. 4, no. 5, pp. e1005448-1-11Contributions to Journals: Articles
Full Mouth Implant-supported Rehabilitation of a Patient with Ectodermal Dysplasia: Clinical Report and Literature ReviewJournal of the International Academy of Periodontology, vol. 17, no. 2, pp. 34-41Contributions to Journals: Articles
Students’ Perceptions of Dental Anatomy Course at The University of JordanJordan Medical Journal, vol. 49, no. 3, pp. 147-154Contributions to Journals: Articles
Pre-immature dendritic cells (PIDC) pulsed with HPV16 E6 or E7 peptide are capable of eliciting specific immune response in patients with advanced cervical cancerJournal of translational medicine, vol. 12, no. 353, pp. 1-10Contributions to Journals: Articles
Functional redundancy of PI3K isoforms in conventional T cells provides a selective Treg-targeting strategy through inhibition of PI3K-delta isoformChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Immune combinational therapy targeting OX40 and IDO synergistically enhances efficacy of a cancer vaccineChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Selective Inhibition of Regulatory T Cells by Targeting the PI3K–Akt PathwayCancer immunology research, vol. 2, no. 11, pp. 1080-1089Contributions to Journals: Articles
AKT inhibition mitigates terminal differentiation and preserves central memory phenotype of CD8 T cellsChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Self-directed study and carving tooth models for learning tooth morphology: perceptions of students at the University of Aberdeen, ScotlandJournal of Dental Education, vol. 77, no. 9, pp. 1147-1153Contributions to Journals: Articles
Anti-PD-1 antibody significantly increases therapeutic efficacy of Listeria monocytogenes (Lm)-LLO immunotherapyJournal for immunotherapy of cancer, vol. 1, pp. 1-9Contributions to Journals: Articles
Analysis of inter-examiner reliability of OSCE assessmentsContributions to Journals: Conference Articles
Dental students’ consistency in applying the ICDAS system within paediatric dentistry38th conference meeting ADEE, pp. e206Contributions to Journals: Abstracts
Fractal geometry enables the objective grading of prostate cancer;: Gleason 3+4 ≠ Gleason 4+3!Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
Age and the architecture of oral mucosaAge, vol. 34, no. 3, pp. 651-8Contributions to Journals: Articles
Addenbrooke's dentistry a second time? (vol 16, pg e10, 2012)European Journal of Dental Education, vol. 16, no. 2, pp. 118-118Contributions to Journals: Articles
Audit of OSCE assessment amongst students and staff in a graduate-entry dental schoolAssociation for Dental Education in Europe (2011), pp. 119-130Contributions to Journals: Abstracts
Dentists’ interest in continuous education in JordanChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Tooth carving as an adjunct to learning tooth morphology: Students’ perceptionAssociation for Dental Education in Europe (2011), pp. 119-130Contributions to Journals: Abstracts
Dentistry a second time?European Journal of Dental Education, vol. 16, no. 1, pp. e10-e18Contributions to Journals: Articles
Association between Graduate Entry Dental Students’ Performance in Objective Structured Practical Examination and their First DegreesContributions to Conferences: Other Contributions
Can students predict their OSCE performance within a graduate-entry school?Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
Fractal Geometry in the Assessment of Oral Epithelial Dysplasia Grading SystemChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Students’ perception of tooth morphology teaching in a graduate-entry dental courseChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Fractal Geometry and the Objective System of Prostate Cancer GradingContributions to Conferences: Other Contributions
Fractal Geometry in the Assessment of Oral Epithelial Dysplasia Grading System8th European Conference on Mathematical and Theoretical Biology, pp. 1-2Contributions to Conferences: Abstracts
Inter-examiner agreement in the assessment of tooth carving:: a pilot studyContributions to Conferences: Other Contributions
Objective Structured Practical Examination (OSPE) for Oral Sciences - Views and Performance of Graduate Entry Dental StudentsContributions to Conferences: Other Contributions
Using Online Dental Case Based Scenarios to Improve Understanding of Basic Sciences: The CLEO ExperienceADEE 36th Annual Meeting 2010Contributions to Conferences: Posters
The Complexity of the Oral Mucosa: A Review of the Use of Fractal GeometryControl engineering and applied informatics, vol. 12, no. 1, pp. 10-14Contributions to Journals: Articles
Fractal dimension as a novel measure of prostate cancer gradingChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Twin-pair rete ridge analysis:: a computer-aided method for facilitating objective histopathological distinction between epithelial dysplasia and carcinoma in-situ of the oral mucosa.Oral Medicine & Pathology, vol. 14, no. 3, pp. 89Contributions to Journals: Articles
Combination of surgery followed by intralesional steroids in treatment of aggressive mandibular giant cell granuloma: A case reportJordan Medical Journal, vol. 43, no. 3, pp. 231-237Contributions to Journals: Articles
Assessment of self-medication of antibiotics in a Jordanian populationMedical principles and practice : international journal of the Kuwait University, Health Science Centre, vol. 18, no. 1, pp. 21-25Contributions to Journals: Articles
Fractals in the Estimation of Tissue Complexity:: A ReviewChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Architectural Changes Associated with Ageing of the Normal Oral Buccal MucosaChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Fifth International Symposium, Fractals in Biology and Medicine, Locarno, March 2008 - AbstractsRivista di biologia-Biology forum, vol. 101, no. 1, pp. 131-158Contributions to Journals: Articles
Morphometrical differences between pseudo-epitheliomatous hyperplasia in granular cell tumours and squamous cell carcinomasHistopathology, vol. 48, no. 4, pp. 407-16Contributions to Journals: Articles
Oral Epithelial Dysplasia:: Can Quantifiable Morphological Features Help in the Grading Dilemma?Contributions to Conferences: Other Contributions
Morphometry of pseudoepitheliomatous hyperplasia: objective comparison to normal and dysplastic oral mucosaeAnalytical and Quantitative Cytology and Histology, vol. 27, no. 4, pp. 232-40Contributions to Journals: Articles
Tissue architecture and cell morphology of squamous cell carcinomas compared to granular cell tumours' pseudo-epitheliomatous hyperplasia and to normal oral mucosaeChapters in Books, Reports and Conference Proceedings: Conference Proceedings
Tissue Architecture in Squamous Cell Carcinoma and Normal Oral Mucosae.Journal of Dental Research, vol. 83, no. Special issue BContributions to Journals: Abstracts
Dentinal Dysplasia type I:: Review of literature and report of 2 cases in one familyCairo Dental Journal, vol. 19, no. 2, pp. 199Contributions to Journals: Articles
Quantification of the global and local complexity of the epithelial-connective tissue interface of normal, dysplastic, and neoplastic oral mucosae using digital imagingPathology, research and practice, vol. 199, no. 7, pp. 475-82Contributions to Journals: Articles