BSc (Hons), MSc, PhD, CStat, FSS, FFPH, FSCT, FRSE, FMedSci
Chair in HSRU
- About
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- Email Address
- m.k.campbell@abdn.ac.uk
- Telephone Number
- +44 (0)1224 273161
- Office Address
-
Aberdeen Centre for Evaluation, Health Sciences Building
Foresterhill Campus
Foresterhill
AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Marion Campbell is Professor of Health Services Research at the University of Aberdeen. She is also Director of the Royal College of Surgeons (RCSEngland) Aberdeen Surgical Trials Centre. Marion is a medical statistician by training, a clinical trialist and methodologist. Her main research interests are in the design, conduct and analysis of clinical trials of complex interventions and of surgical, device and critical care trials. She has published widely on clinical trials methodology including on cluster randomised trials, design of trials of surgical interventions, pragmatic trials and trials reporting. She has served on many national and international funding agencies and committees and is an elected Fellow of the Academy of Medical Sciences, the Royal Society of Edinburgh, the Faculty of Public Health, and the International Society for Clinical Trials and is a previous NIHR senior investigator.
Previously Marion was Vice-Principal (Research) for the University of Aberdeen. In this role, she had primary responsibility for promoting the University's research ambitions, ensuring effective delivery of the University's strategic objectives for research. and for enabling a research context for academic colleagues to deliver world-leading, impactful research. She also led on the establishment of interdisciplinary research across the institution. Prior to this, Marion was Dean of Research for Life Sciences and Medicine following ten years as Director of the Scottish Government core-funded Health Services Research Unit.
Marion graduated with an honours degree in Statistics from the University of Aberdeen and subsequently gained an MSc in Statistics and PhD in Public Health. Following early career appointments within the National Health Service in the fields of Operational Research and Statistics of Medical Audit, she joined the University of Aberdeen in 1993.
External Memberships
Chair. NIHR/MRC Better Methods Better Research Panel
Member, MRC Training and Careers Strategy Board
Member of REF2021 UoA2 sub-panel
- Research
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Research Overview
Marion’s main research interests are in the design, conduct and analysis of clinical trials especially complex trial design and the design and conduct of surgical and device trials. She has also published widely on clinical trials methodology including on cluster randomised trials, design of trials of non-pharmacological interventions, pragmatic trials and trials reporting.
Some examples of current and recent research include:
REINFORCE: The NIHR-funded REINFORCE study aims to evaluation the introduction and scale up of robot-assisted surgery across the NHS. Further information is available at: https://www.abdn.ac.uk/hsru/what-we-do/research/projects/reinforce-291
UK-REBOA: The NIHR-funded UK-REBOA trial aims to establish the clinical and cost-effectiveness of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), in addition to standard major trauma centre treatment, for the treatment of patients with life-threatening torso haemorrhage. The trial results have been published in JAMA (https://jamanetwork.com/journals/jama/fullarticle/2810757) and found that REBOA did not reduce and may increase mortality.
TOPKAT: The NIHR-funded TOPKAT trial is investigating the clinical and cost effectiveness of partial (PKR) vs total (THR) knee replacements. The trial recruited 528 patients from across the UK. Five year results have been published in the Lancet (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31281-4/fulltext) and showed that PKR has similar, if not a slightly better clinical outcome than TKR. More importantly, the economic benefit of using PKR is substantial. Patients are now being followed up to 10 years.
CLASS: The NIHR-funded CLASS trial is assessing the clinical and cost-effectiveness of three treatment modalities for the treatment of varicose veins: a) foam; b) EVLA with subsequent foam to varicosities when required; and c) surgery. A total of 798 adult patients were recruited into the trial and randomised to one of the treatment options. Early results (http://www.nejm.org/doi/full/10.1056/NEJMoa1400781) and five year follow-up results (https://www.nejm.org/doi/full/10.1056/NEJMoa1805186 were published in the New England Journal of Medicine.
KAT: The NIHR-funded KAT trial, explores different knee replacement surgery options (the effects of patellar resurfacing, mobile bearings and metal backing were investigated). A total of 116 surgeons in 34 UK centres participated and 2352 participants were randomised. Ten year outcomes were previously published (https://www.journalslibrary.nihr.ac.uk/hta/hta18190/#/abstract); long term follow up to 20 years is underway.
Research Areas
Applied Health Sciences
Research Specialisms
- Healthcare Science
- Medical Statistics
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
- Publications
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Page 3 of 5 Results 101 to 150 of 248
Use of the h-index to measure the quality of the output of health services researchers
Journal of Health Services Research & Policy, vol. 19, no. 2, pp. 102-109Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1177/1355819613518766
A randomised controlled trial of the clinical effectiveness and cost-effectiveness of different knee prostheses: the Knee Arthroplasty Trial (KAT)
Health Technology Assessment, vol. 18, no. 19, pp. 1-235, vii-viiiContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta18190
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4d9353cb-16ab-4197-ba4c-205f60a12a78/download
Is it worthwhile to conduct a randomized controlled trial of glaucoma screening in the United Kingdom?
Journal of Health Services Research & Policy, vol. 19, no. 1, pp. 42-51Contributions to Journals: ArticlesDetermining information for inclusion in a decision-support intervention for clinical trial participation: A modified Delphi approach
Clinical Trials, vol. 10, no. 6, pp. 967-976Contributions to Journals: ArticlesDetermining items for inclusion in a decision support intervention for clinical trial participation: a modified Delphi approach
Contributions to Journals: Conference ArticlesRecruitment to trials: insights from a meta-ethnography of qualitative studies
Contributions to Journals: Conference ArticlesService user groups as co-applicants on a platform study for a trial
Trials, vol. 14, no. Suppl 1, pp. O35Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-14-S1-O35
Clinical stakeholders' opinions on the use of selective decontamination of the digestive tract in critically ill patients in intensive care units: an international Delphi study
Critical Care, vol. 17, no. 6, R266Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/cc13096
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7ec58d5e-df4d-40ba-a173-a8d9b058d035/download
Clinical components and associated behavioural aspects of a complex healthcare intervention: Multi-methods study of selective decontamination of the digestive tract in critical care
Australian Critical Care, vol. 26, no. 4, pp. 173-179Contributions to Journals: ArticlesRecruitment to clinical trials: a meta-ethnographic synthesis of studies of reasons for participation
Journal of Health Services Research & Policy, vol. 18, no. 4, pp. 233-241Contributions to Journals: ArticlesTotal or Partial Knee Arthroplasty Trial - TOPKAT: study protocol for a randomised controlled trial
Trials, vol. 14, 292Contributions to Journals: ArticlesClinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial)
Health Technology Assessment, vol. 17, no. 22, pp. 1-166Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta17220
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f5daf7d0-3795-4ce7-ab56-52bfae051be7/download
Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX)
BMJ, vol. 346, f1908Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.f1908
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/3c53c433-ab0f-46f9-bf5a-cfc91d23341c/download
Five-year results of a randomised controlled trial comparing mobile and fixed bearings in total knee replacement
Journal of Bone & Joint Surgery (US Volume), vol. 95-B, no. 4, pp. 486-492Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1302/0301-620X.95B4.29454
Investigating the relationship between predictability and imbalance in minimisation: a simulation study
Trials, vol. 14, 86Contributions to Journals: ArticlesDeveloping the specifications of an Open Angle Glaucoma screening intervention in the United Kingdom: a Delphi approach
BMC Health Services Research, vol. 12, 447Contributions to Journals: ArticlesUse of randomisation in clinical trials: a survey of UK practice
Trials, vol. 13, 198Contributions to Journals: ArticlesConsort 2010 statement: extension to cluster randomised trials
BMJ, vol. 345, pp. e5661Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.e5661
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/1e3e920e-e17d-466b-9e52-d8e04e907140/download
Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D3 and/or calcium (RECORD trial)
Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 2, pp. 614-622Contributions to Journals: ArticlesA pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery: the FOCCUS study
Critical Care, vol. 15, no. 6, R296Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/cc10592
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/b492e4c5-83b8-41c7-8566-d7f07ae47277/download
Patellar resurfacing in total knee replacement: five-year clinical and economic results of a large randomized controlled trial
The Journal of Bone & Joint Surgery. American Volume, vol. 93, no. 16, pp. 1473-1481Contributions to Journals: ArticlesDeveloping the clinical components of a complex intervention for a glaucoma screening trial: a mixed methods study
BMC Medical Research Methodology, vol. 11, no. -, 54Contributions to Journals: ArticlesRandomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients
British Medical Journal, vol. 342, no. -, d1542Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.d1542
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/5d013acc-043a-43b2-ba52-7cf69e81435d/download
Using a business model approach and marketing techniques for recruitment to clinical trials
Trials, vol. 12, pp. 74Contributions to Journals: ArticlesDeveloping a placebo-controlled trial in surgery: issues of design, acceptability and feasibility
Trials, vol. 12, 50Contributions to Journals: ArticlesA Cost-Utility Analysis of Microwave Endometrial Ablation versus Thermal Balloon Endometrial Ablation
Value in Health, vol. 13, no. 5, pp. 528-534Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1524-4733.2010.00704.x
A pragmatic multi-centre randomised controlled trial of fluid loading and level of dependency in high-risk surgical patients undergoing major elective surgery: trial protocol
Trials, vol. 11, no. 41Contributions to Journals: ArticlesReasons for participating in randomised controlled trials: conditional altruism and considerations for self
Trials, vol. 11, pp. 31Contributions to Journals: ArticlesPromoting public awareness of randomised clinical trials using the media
British Journal of Clinical Pharmacology, vol. 69, no. 2, pp. 128-135Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2125.2009.03561.x
Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of osteoarthritis of the knee: a mixed methods study of the feasibility of conducting a surgical placebo-controlled trial (the KORAL study)
Health Technology Assessment, vol. 14, no. 5, pp. 1-180Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta14040
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/3550d3a2-f245-497a-8daf-c646464d8254/download
Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone
Journal of Bone and Mineral Research, vol. 25, no. 1, pp. 20-31Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1359/jbmr.090709
A study of the perceived risks, benefits and barriers to the use of SDD in adult critical care units (the SuDDICU study)
Trials, vol. 11, pp. 117Contributions to Journals: ArticlesPragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery
Edinburgh, United Kingdom: Chief Scientist Office. 7 pagesBooks and Reports: Commissioned ReportsThe PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial
British Medical Journal, vol. 339, b3723Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.b3723
When should a placebo be used in surgical trials?
Clinical Trials, vol. 6, no. 5, pp. 509Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1177/1740774509345176
Evaluation and stages of surgical innovations
The Lancet, vol. 374, no. 9695, pp. 1089-1096Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0140-6736(09)61083-7
No surgical innovation without evaluation: the IDEAL recommendations
The Lancet, vol. 374, no. 9695, pp. 1105-1112Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0140-6736(09)61116-8
Laparoscopic fundoplication compared with medical management for gastro-oesophageal reflux disease: cost effectiveness study
British Medical Journal, vol. 339, b2576Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.b2576
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/53d565f9-29a7-4eff-b4f1-9082a53b6c05/download
Clinical outcomes from a randomised comparison of Microwave Endometrial Ablation with Thermal Balloon endometrial ablation for the treatment of heavy menstrual bleeding
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 116, no. 8, pp. 1038-1045Contributions to Journals: ArticlesMeaning behind measurement: self-comparisons affect responses to health-related quality of life questionnaires
Quality of Life Research, vol. 18, no. 2, pp. 221-230Contributions to Journals: Articles- [ONLINE] http://aura.abdn.ac.uk/handle/2164/306
- [ONLINE] DOI: https://doi.org/10.1007/s11136-008-9435-1
The Knee Arthroplasty Trial (KAT): design features, baseline characteristics, and two-year functional outcomes after alternative approaches to knee replacement
The Journal of Bone & Joint Surgery. American Volume, vol. 91, no. 1, pp. 134-141Contributions to Journals: Articles- [ONLINE] http://aura.abdn.ac.uk/handle/2164/272
- [ONLINE] DOI: https://doi.org/10.2106/JBJS.G.01074
Cellulose, modified cellulose and synthetic membranes in the haemodialysis of patients with end-stage renal disease
Cochrane Database of Systematic Reviews, no. 3, pp. CD003234Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/14651858.CD003234.pub2
Minimal access surgery compared with medical management for chronic gastro-oesophageal reflux disease: UK collaborative randomised trial
British Medical Journal, vol. 337, a2664Contributions to Journals: Articles- [ONLINE] http://aura.abdn.ac.uk/handle/2164/270
- [ONLINE] DOI: https://doi.org/10.1136/bmj.a2664
Minimal access surgery compared with medical management for chronic gastro-oesophageal reflux disease: UK collaborative randomised trial
British Medical Journal, vol. 337, a2664Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.a2664
Detection of adverse events in a Scottish hospital using a consensus-based methodology
Scottish Medical Journal, vol. 53, no. 4, pp. 26-30Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1258/rsmsmj.53.4.26
The effectiveness and cost-effectiveness of minimal access surgery amongst people with gastro-oesophageal reflux disease: a UK collaborative study. The REFLUX trial
Health Technology Assessment, vol. 12, no. 31Contributions to Journals: Articles- [ONLINE] http://hdl.handle.net/2164/264
- [ONLINE] DOI: https://doi.org/10.3310/hta12310
Simple imputation methods were inadequate for missing not at random (MNAR) quality of life data
Health and Quality of Life Outcomes, vol. 6, 57Contributions to Journals: ArticlesProtocol for stage 2 of the GaP study (genetic testing acceptability for Paget's disease of bone): a questionnaire study to investigate whether relatives of people with Paget's disease would accept genetic testing and preventive treatment if they were available
BMC Health Services Research, vol. 8, no. 116, pp. 116Contributions to Journals: ArticlesRecruitment to randomised trials: Strategies for trial enrolment and participation study. The STEPS study
Health Technology Assessment, vol. 11, no. 48, pp. 1-126Contributions to Journals: Literature Reviews- [ONLINE] http://aura.abdn.ac.uk/handle/2164/179
- [ONLINE] DOI: https://doi.org/10.3310/hta11480
Randomised trial of glutamine and selenium supplemented parenteral nutrition for critically ill patients: Protocol version 9, 19 February 2007 known as SIGNET (Scottish Intensive Care Glutamine or seleNium Evaluative Trial)
Trials, vol. 8, 25Contributions to Journals: Articles- [ONLINE] http://aura.abdn.ac.uk/handle/2164/175
- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-8-25