MR BADRI RISHEH

MR BADRI RISHEH
MR BADRI RISHEH

MR BADRI RISHEH

Research PG

About

Office 5:20, Fifth Floor

Institute of Medical Sciences, Forsterhill Campus

Aberdeen

 AB25 2ZD

School Of Mmsn

Biography

I studied Pharmacy at Damascus University, Syria. During my undergraduate studies, I did mandatory placements for two years at a community pharmacy learning the role and the duties of the community pharmacist. However, I wanted to have further experience in laboratory works and had the chance to work in a clinical biochemistry laboratory as an observer. This had further boosted my interests to pursue working in molecular biology and biochemistry laboratories. Thus, I applied for molecular biology taught MSc programme at the University of Hertfordshire.

During my MSc program, I conducted with my colleagues four problem based learning projects on different topics. One of them was my favorite, which was engineering monoclonal antibodies (FAB fragments) against a cluster of differentiation 4 (CD4) and C-C chemokine receptor type 5 (CCR5) to prevent the entrance of HIV virus. Another research, I was involved in, was linked to the Poliomyelitis tragedy that affected many children in Syria (an abolished disease caused by poliovirus has appeared again in the last two years due to the lack of proper diagnostic tools and the lack of vaccines).

In the third semester, I had the chance to conduct a research, under the supervision of Dr Philip Sawle - University of Hertfordshire about the role of Homocysteine (HCy) as an independent risk factor of atherosclerosis and its involvement in inhibiting or inducing important signalling pathways required for cell survival in a stress stimulus using rat aortic smooth muscle cells.

I applied applied for a Ph.D. in Medical Sciences at the University of Aberdeen for the fall of 2018, to identify targets for selective modulation of immune cells while understanding the specific mechanisms that control T cell development and responses, under the supervision of Dr Rasha Abu Eid, Dr Frank Ward, and Dr Raif Yuecel. I was accepted and awarded the Elphinstone scholarship for international students and currently conducting my Ph.D. project.

Research

Research Overview

Cancer Immunotherapy Enhancing the CD8 T cells’ response against tumours.

Interested in topics such as cell survival mechanisms, cell senescence, cell fate and the involved transcriptional factors in the arrest of the cell cycle and the mechanisms to modifying them.

Interested in diseases such as Pulmonary hypertension, cystic fibrosis and Primary ciliary dyskinesia (PCD).

Interested in studying acute myeloid leukemia (AML) the growth of malignant leukocytes and the suppression of regular hematopoiesis.

Studying the role of Heam-Oxygenase-1 in inducing particular cell survival pathways in low oxygen availability and in response to some pro-inflammatory proteins.

Engineering and producing Monoclonal antibodies to prevent the entrance of HIV to the immune cells.

Third generation sequencing (conducted a study about the possibility of using POC diagnostic test using third generation sequencing (TGS) methods.

The production of proteins in commercial amounts using bacteria or yeast.

Current Research

Modulators of T Cell Function in Cancer Immunotherapy. Ph.D. project.