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The University of Aberdeen
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Aberdeen AB24 3UE
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Since November 2013 I work part-time for the University of Aberdeen. My main affiliation is now the Heinrich-Heine University Düsseldorf, Germany. Please follow our activities on the group's homepage.
Oliver Ebenhoeh studied Mathematics and Physics at the University of Heidelberg (Germany), and did his PhD in Theoretical Biophysics at the Humboldt University, Berlin (Germany), where he continued to work as a postdoctoral researcher until 2006. He established his research group 'Systems Biology and Mathematical Modelling' at the Max-Planck-Institute of Molecular Plant Physiology in Potsdam (Germany) in 2007. He moved to the University of Aberdeen in 2009 where he was appointed Reader in Systems Biology as a joint position of the Institute for Complex Systems and Mathematical Biology and the Institute of Medical Sciences. Since 2010 he is coordinator of the Theroetical Systems Biology research programme. Since October 2012 he is the coordinator of the Marie-Curie Initial Training Network 'AccliPhot', which is supported by €4 Mio by the European Commission and comprises 12 partners from 6 countries.
Oliver Ebenhoeh's research group is focussed on understanding molecular interaction networks using theoretical approaches. An overall goal of his research is to link physical sciences to biology to derive a theoretical understanding of living systems.
Plant Systems Biology
A strong research focus lies on the development of mathematical models of photosynthesis and plant metabolism. This research is now supported by the European Commission through the Marie-Curie Initial Training Network AccliPhot.
- How do plants adapt to rapidly changing light intensities while maximally exploiting the available light?
- How is the photosynthetic electron transport chain regulated by metabolic demand?
- How is starch partitioning controlled?
- How is metabolism connected with the circadian clock in plants?
- What mechanisms are responsible for creating the highly ordered, macroscopic starch granules?
- How is the catalysis on the granule surface regulated?
Enzymes acting on polymers are difficult to describe in mathematical models because of the complexity of all possible polymeric structures. We are developing new concepts in which we describe biochemical systems involving polymers in the language of statistical thermodynamics. This powerful links between the fields of biochemistry and physics enables completely new kinds of analysis. We aim to gather understanding how complex structures can emerge from relatively simple enzymatic action patterns.
Large-scale network analysis
His group has developed a novel concept, the method of network expansion, to study large-scale metabolic networks. By this, structural to functional properties of such networks could be systematically related. Moreover, from identifying characteristic features that cannot be expected to have appeared by chance, important clues about the evolutionary history of such networks could be obtained.
Specific small-scale systems
His group also applies traditional, differential equation based, modelling techniques to study metabolic, signalling and regulatory systems to understand their underlying design principles. Systems under investigation include starch metabolism in plants and photosynthesis, circadian clocks in plants and green algae, transport and metabolic processes taking place in plant roots and the surrounding soil.
Symbiosis and Parasitism
A key observation is that almost no organism lives in complete isolation. In fact, only a small number of microbes are easily cultivatable. A strategic goal of our research activities is to understand the principles that lead to a stability of complex communities. To this end, we study specific parasites and compare their metabolism and genomes to free living relatives. By this, we hope to gain insight into the evolutionary origins of parasitism. To study symbiosis, we focus on the interaction of plants with their rhizosphere. Many plants undergo symbiosis with mycorrhizal fungi, from which both interaction partners benefit.
Investigator on BBSRC sLoLa BB/L002957/1 "Algal oils by design: a new biotech platform for high-value lipids". 05/2014-04/2018. Coordinator: S. Purton, University College London. £2,363,928
Investigator on BBSRC sLoLa BB/K003356/1 "A platform for rapid and precise DNA module rearrangements in Synthetic Biology". 04/2013-03/2018. Coordinator: M. Stark, University of Glasgow. £3,265,356
Environmental Acclimation of Photosynthesis (AccliPhot). FP7 Marie-Curie Initial Training Network. 10/2012-09/2016. Coordinator: O. Ebenhöh. €4,000,000.
LINKING THE CLOCK TO METABOLISM - TIMET (EUROPEAN COMMISSION). 03/2010-02/2015. Coordinator: A. Millar, University of Edinburgh. €5,844,329
DO NOVEL ACIDOPHILIC ARCHAEAL AMMONIA OXIDISERS SOLVE THE PARADOX OF NITRIFICATION IN ACID SOILS? (NERC). 10/2011-03/2015. Nicol, G. W., Prosser, J. I. & Ebenhöh, O. £430,811
A genetic dissection of traits required for sustainable water use in rice using Genome Wide Association Studies (GWAS). BBSRC. 01/2012-12/2015
A. Price, A. Meharg, O. Ebenhöh, D. Salt, G. Norton. £931,130
A systems approach to optimise photosynthetic production of molecular hydrogen. Royal Society International Exchanges. 03/2012-02/2014. O. Ebenhöh & J.-D. Rochaix (Université de Genève). £12,000