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The School of Natural and Computing Sciences

Dr Thomas Baddeley

Dr Thomas Baddeley
Dr Thomas Baddeley
Dr Thomas Baddeley

Senior Research Fellow

About
Telephone Number
+44 (0)1224 274238
School/Department
School of Natural and Computing Sciences
Research

Research Overview

The development and use of new analytical methods in the study of small organic molecules undergoing clinical evaluation.

The synthesis and study of novel organic compounds for use as potential drug candiates and excipients.

The study of the physical properties of novel oligosaccharides

Publications

Page 1 of 4 Results 1 to 10 of 33

  • HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

    Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.
    Biomedicines, vol. 10, no. 4, 867
    Contributions to Journals: Articles

  • Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

    Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
    Contributions to Journals: Articles

  • Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

    Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
    Contributions to Journals: Articles

  • Crystal structures and Hirshfeld surface analyses of a des-A-B-aromatic steroidal compound, and two of its derivatives, having a trans-2,3,4,5-tetrahydro-3a-methyl-7-methoxybenz[e]indane skeleton-structural comparisons with reported tetrahydrobenz[e]indene derivatives

    Gomes, L. R., Low, J. N., Turner, A. B., Nowicki, A. W., Baddeley, T. C., Wardell, J. L.
    Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, vol. 74, no. 9, pp. 649-663
    Contributions to Journals: Articles

  • N′-(1,3-Benzo­thia­zol-2-yl) benzene­sulfono­hydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry

    Baddeley, T. C., de Souza, M. V. N., Wardell, J. L., Jotani, M. M., Tiekink, E. R. T.
    Acta Crystallographica Section E: Crystallographic Communications, vol. 75, no. 4, pp. 516-523
    Contributions to Journals: Articles

  • Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives

    Pinheiro, A. C., de Souza, M. V. N., Lourenco, M. C. S., da Costa, C. F., Baddeley, T. C., Low, J. N., Wardell, S. M. S. V., Wardell, J. L.
    Journal of Molecular Structure, vol. 1178, pp. 655-668
    Contributions to Journals: Articles

  • Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements

    Gomes, L. R., Low, J. N., Turner, A. B., Baddeley, T. C., Wardell, J. L.
    Steroids, vol. 140, pp. 92-103
    Contributions to Journals: Articles

  • Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

    Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131
    Contributions to Journals: Articles

  • A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

    Schwab, K., Frahm, S., Horsley, D., Rickard, J. E., Melis, V., Goatman, E. A., Magbagbeolu, M., Douglas, M., Leith, M. G., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., Harrington, C. R., Theuring, F.
    Frontiers in Molecular Neuroscience, vol. 10, 447
    Contributions to Journals: Articles

  • Structural studies of (E)-2-(benzylidene)-1- tetralone derivatives: Crystal structures and Hirshfeld surface analysis

    Baddeley, T. C., Gomes, L. R., Low, J. N., Turner, A. B., Wardell, J. L., Watson, G. J.
    Zeitschrift fur Kristallographie - Crystalline Materials, vol. 232, no. 10, pp. 697-718
    Contributions to Journals: Articles
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