BSc, PhD (KC, London)
Chair in Pharmaceutical Industrial Chemistry
- About
-
- Email Address
- j.storey@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272926
- Office Address
- Meston Room G106
- School/Department
- School of Natural and Computing Sciences
External Memberships
Head Chemist for TauRx Therapeutics
- Research
-
Research Overview
Free Radical Chemistry, Organic Methodology, Medicinal Chemistry
Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.
An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.
Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.
Current Research
Selected Current Projects
- Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
- A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
- Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
- New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
- The use of organic molecules as asymmetric catalysts.
Â
- Teaching
-
Teaching Responsibilities
Professor Storey teaches in the following courses:Â
- CM1010
- CM1011
- CM4017/CM3024 Honours/Advanced Chemistry
- CM5003 MChem Chemistry Applications
Â
- Publications
-
Page 3 of 15 Results 21 to 30 of 148
The effect of a lateral alkyloxy chain on the ferroelectric nematic phase
RSC Advances, vol. 12, no. 45, pp. 29482-29490Contributions to Journals: ArticlesNovel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography
International journal of analytical chemistry, vol. 2022, 9171836Contributions to Journals: ArticlesLiquid Crystal Dimers and Smectic Phases from the Intercalated to the Twist-Bend
Crystals, vol. 12, no. 9, 1245Contributions to Journals: Review articlesIntrinsically chiral ferronematic liquid crystals: An inversion of the helical twist sense at the chiral nematic – Chiral ferronematic phase transition
Journal of molecular liquids, vol. 361, 119532Contributions to Journals: ArticlesNew patterns of twist-bend liquid crystal phase behaviour: the synthesis and characterisation of the 1-(4-cyanobiphenyl-4′-yl)-10-(4-alkylaniline-benzylidene-4′-oxy)decanes (CB10O·m)
Soft matter, vol. 18, no. 25, pp. 4679-4688Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/d2sm00162d
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/21140/1/Alshammari_etal_SM_New_Patterns_of_VOR.pdf
- [ONLINE] View publication in Scopus
A convenient one-pot synthesis, and characterisation of the ω-bromo-1-(4-cyanobiphenyl-4’-yl) alkanes (CBnBr)
Liquid Crystals, vol. 49, no. 12, pp. 1706-1716Contributions to Journals: ArticlesControlling spontaneous chirality in achiral materials: liquid crystal oligomers and the heliconical twist-bend nematic phase
Chemical Communications, vol. 58, no. 34, pp. 5285-5288Contributions to Journals: ArticlesHMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
Biomedicines, vol. 10, no. 4, 867Contributions to Journals: ArticlesFlexoelectric Polarization in a Nematic Liquid Crystal Enhanced by Dopants with Different Molecular Shape Polarities
ACS Omega, vol. 7, no. 11, pp. 9785-9795Contributions to Journals: ArticlesHelical phases assembled from achiral molecules: Twist-bend nematic and helical filamentary B4 phases formed by mesogenic dimers
Journal of molecular liquids, vol. 346, 118180Contributions to Journals: Articles