BSc, PhD (KC, London)
Chair in Pharmaceutical Industrial Chemistry
- About
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- Email Address
- j.storey@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272926
- Office Address
- Meston Room G106
- School/Department
- School of Natural and Computing Sciences
External Memberships
Head Chemist for TauRx Therapeutics
- Research
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Research Overview
Free Radical Chemistry, Organic Methodology, Medicinal Chemistry
Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.
An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.
Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.
Current Research
Selected Current Projects
- Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
- A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
- Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
- New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
- The use of organic molecules as asymmetric catalysts.
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- Teaching
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Teaching Responsibilities
Professor Storey teaches in the following courses:Â
- CM1010
- CM1011
- CM4017/CM3024 Honours/Advanced Chemistry
- CM5003 MChem Chemistry Applications
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- Publications
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Ferroelectric Nematic-Isotropic Liquid Critical End Point
Physical Review Letters, vol. 130, no. 21, 216802Contributions to Journals: ArticlesMolecular Shape, Electronic Factors and the Ferroelectric Nematic Phase: Investigating the Impact of Structural Modifications
Chemistry : a European Journal, vol. 29, no. 28, e202300073Contributions to Journals: ArticlesShort I⋯O Interactions in the Crystal Structures of Two 2-Iodo-Phenyl Methyl-Amides as Substrates for Radical Translocation Reactions
Chemistry, vol. 5, no. 2, pp. 1233–1242Contributions to Journals: ArticlesUsing lateral substitution to control conformational preference and phase behaviour of benzanilide-based liquid crystal dimers
ChemPhysChem, vol. 24, no. 7, e202200758Contributions to Journals: ArticlesThe effects of alkylthio chains on the properties of symmetric liquid crystal dimers
New Journal of Chemistry, vol. 47, no. 15, pp. 7356-7368Contributions to Journals: ArticlesIntrinsically Chiral Twist-Bend Nematogens: Interplay of Molecular and Structural Chirality in the NTB Phase
ChemPhysChem, vol. 24, no. 6, e202200807Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/cphc.202300105
Temperature Dependence of the Electroclinic Effect in the Twist-Bend Nematic Phase
Crystals, vol. 13, no. 3, 465Contributions to Journals: ArticlesCan even-membered liquid crystal dimers exhibit the twist-bend nematic phase?: The preparation and properties of disulphide and thioether linked dimers
Liquid Crystals, vol. 50, no. 7-10, pp. 1362-1374Contributions to Journals: ArticlesSolid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)
Frontiers in Neuroscience, vol. 16, 988074Contributions to Journals: ArticlesSyntheses and Crystal Structures of Three Chiral Oxazolidinones with Different Ring Conformations
Crystals, vol. 12, no. 11, 1598Contributions to Journals: Articles