Dr James Sinclair

Dr James Sinclair
Dr James Sinclair
Dr James Sinclair

Senior Research Fellow

About
Publications

Page 1 of 1 Results 1 to 11 of 11

  • Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease

    Harrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, L. J., Wischik, C. M.
    The Journal of Biological Chemistry, vol. 290, no. 17, pp. 10862-10875
    Contributions to Journals: Articles
  • Making thiosulfate-disubstituted-amino-optionally substituted-phenyl-imino-optionally substituted-cyclohexadienylidene-N,N-disubstituted-ammoniums comprises carrying out nitrosyl reduction, thiosulfonic acid formation and oxidative coupling

    Sinclair, J. P., Nicoll, S. L., Storey, J. M. D.
    Patents: Patents
  • New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

    Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., Wood, B. A.
    Patents: Patents
  • 3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents
  • Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P.
    Patents: Patents
  • Methods of synthesis and/or purification of diaminophenothiazinium compounds

    Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents
  • Co-operative stabilisation of a 15-component nanostructure

    Plater, M. J., Sinclair, J. P., Aiken, S.
    Journal of Chemical Research, vol. 2007, no. 5, pp. 287-290
    Contributions to Journals: Articles
  • New tetrahydro-1,2,4,5-tetrazinan-3-ones and oxoverdazyl free radicals

    Plater, M., Sinclair, J., Kemp, S., Gelbrich, T., Hursthouse, M., Gómez-García, C.
    Journal of Chemical Research, vol. 8, no. 8, pp. 515-520
    Contributions to Journals: Articles
  • The first double helical coordination network with shared copper atoms

    Plater, M. J., De Silva, B., Sinclair, J. P., Gelbrich, T., Hursthouse, M. B.
    Journal of Molecular Structure, vol. 784, no. 1-3, pp. 269-271
    Contributions to Journals: Articles
  • Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)

    Storey, J. M. D., Sinclair, J. P., Marshall, C., Tan, H. W., Wischik, C. M.
    Patents: Patents
  • The CA.M lattice revisited. Gel formation from a linear bis-isocyanuric acid and 2-amino-4,6-bis-(4-tert-butylphenylamino)-1,3,5-triazine

    Plater, M., Sinclair, J., Aiken, S., Gelbrich, T., Hursthouse, M.
    Tetrahedron, vol. 60, no. 30, pp. 6385-6394
    Contributions to Journals: Articles

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