Dr Colin Marshall | The School of Natural and Computing Sciences

Dr Colin Marshall

Senior Research Fellow

About

Email Address: c.marshall@abdn.ac.uk
Telephone Number: +44 (0)1224 272940
School/Department: School of Natural and Computing Sciences

Research

Current Research

http://taurx.com/

Publications

Page 1 of 1 Results 1 to 14 of 14

Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease
2015 - Published
Harrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, L. J., Wischik, C. M.
The Journal of Biological Chemistry, vol. 290, no. 17, pp. 10862-10875
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1074/jbc.M114.616029
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4569/1/J._Biol._Chem._2015_Harrington_10862_75.pdf
New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes
2012 - Published
Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., Wood, B. A.
Patents: Patents
Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants
2012 - Published
Larch, C. P., Storey, J. M. D., Williamson, C., Marshall, C., Kemp, S. J.
Patents: Patents
3,7-diamino-10H-phenothiazine salts and their use: WO2007110627
2011 - Published
Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
Patents: Patents
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4352/1/WO2007110627.pdf
Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds
2010 - Published
Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P.
Patents: Patents
Methods of synthesis and/or purification of diaminophenothiazinium compounds
2009 - Published
Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
Patents: Patents
(4S,5S)-2,2-dimethyl-4,5-bis(3-methyl-2-thioxo-2,3-dihydro-1H-imidazol-1-ylmethyl)-1,3-dioxolane
2008 - Published
Marshall, C., Harrison, W. T. A.
Acta Crystallographica Section E: Structure Reports Online, vol. 64, no. 1, o58
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1107/S1600536807055948
(4R,5R)-2,2-dimethyl-4,5-bis[2-(3-methyl-2-thioxo-2,3-dihydro-1H-imidazol-2-yl)ethyl]-1,3-dioxolane
2007 - Published
Marshall, C., Harrison, W. T. A.
Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 12, o4878
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1107/S160053680706148X
(4R,5R)-4,5-Bis{2-[3-(2,6-diisopropyl-phenyl)-2-thioxoimidazolidin-3-yl]ethyl}-2,2-dimethyl-1,3-dioxolane
2007 - Published
Marshall, C., Harrison, W. T. A.
Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 12, o4503
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1107/S1600536807050349
(4S,5S)-4,5-Bis(3-cyclohexyl-2-thioxobenzimidazol-1-ylmethyl)-2,2-dimethyl-1,3-dioxolane from synchrotron data
2007 - Published
Marshall, C., Harrison, W. T. A.
Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 12, o4502
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1107/S1600536807053342
Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
2006 - Published
Storey, J. M. D., Sinclair, J. P., Marshall, C., Tan, H. W., Wischik, C. M.
Patents: Patents
Steric variations between the synthesis of a stable chiral C-2-symmetric diimidazolidinylidene and an electron-rich tetraazafulvalene
2006 - Published
Marshall, C., Ward, M. F., Skakle, J. M. S.
Synthesis, vol. 6, pp. 1040-1044
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1055/s-2006-926361
Synthesis of chiral chelating N-heterocyclic carbene complexes of ruthenium
2005 - Published
Marshall, C., Ward, M. F., Harrison, W. T. A.
Journal of Organometallic Chemistry, vol. 690, pp. 3970-3975
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jorganchem.2005.05.036
Synthesis and structure of C₂-symmetric N-heterocyclic carbene complexes of palladium
2004 - Published
Marshall, C., Ward, M. F., Harrison, W. T. A.
Tetrahedron Letters, vol. 45, pp. 5703-5706
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.tetlet.2004.05.085

Update

Current Research

Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease

New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants

3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds

Methods of synthesis and/or purification of diaminophenothiazinium compounds

(4S,5S)-2,2-dimethyl-4,5-bis(3-methyl-2-thioxo-2,3-dihydro-1H-imidazol-1-ylmethyl)-1,3-dioxolane

(4R,5R)-2,2-dimethyl-4,5-bis[2-(3-methyl-2-thioxo-2,3-dihydro-1H-imidazol-2-yl)ethyl]-1,3-dioxolane

(4R,5R)-4,5-Bis{2-[3-(2,6-diisopropyl-phenyl)-2-thioxoimidazolidin-3-yl]ethyl}-2,2-dimethyl-1,3-dioxolane

(4S,5S)-4,5-Bis(3-cyclohexyl-2-thioxobenzimidazol-1-ylmethyl)-2,2-dimethyl-1,3-dioxolane from synchrotron data

Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)

Steric variations between the synthesis of a stable chiral C-2-symmetric diimidazolidinylidene and an electron-rich tetraazafulvalene

Synthesis of chiral chelating N-heterocyclic carbene complexes of ruthenium

Synthesis and structure of C2-symmetric N-heterocyclic carbene complexes of palladium

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Contributions to Journals

Patents

Synthesis and structure of C₂-symmetric N-heterocyclic carbene complexes of palladium