AB1.H1.5 +D1 The Gall Bladder

Accessory Glands of GI Tract:

  • The gall bladder is a muscular bag which stores the bile that is produced by the liver
  • Bile is an emulsifier of fats and functions in the duodenum
  • When fats are detected in the duodenum the gall bladder is stimulated to contract and deliver the stored bile, via the biliary tree, into the duodenum
  • The gall bladder is lined by a simple columnar epithelium sitting on a thin layer of loose connective tissue (the lamina propria)
  • There is no submucosa
  • There is a thin layer of smooth muscle with the muscle cells organised in different planes
  • When the muscle contracts, the lumen of the gall bladder is reduced and bile is pushed into the biliary ducts where it is directed to the duodenum
  • Part of the gall bladder has an adventitia which binds it to the liver
  • Some parts are covered with a serosa (peritoneum)
  • The tubes of the biliary tree are lined by a simple columnar epithelium supported by connective tissue
  • There is a thin muscular layer in the wall of the ducts although in some parts it is thickened to form sphincters which control the direction of flow of the bile

Questions:

    How does bile get from the hepatocytes in the liver (where it is produced) to the gall bladder?
    When bile is required the muscle wall contracts to push stored bile out, where does the bile get delivered to?
    What route does the bile take to get to the region of the body where it functions?
    What prevents the bile from being delivered back to the liver?

    What is the difference between a serosa and an adventitia?
    On the micrograph, does the part of the gall bladder wall marked with an 'X' have an adventitia or a serosa?

Micrograph of Gall Bladder:

    Gall Bladder
  • This low magnification micrograph shows an area of liver on the left and part of the gall bladder on the right
  • The lumen of the gall bladder is lined by a simple columnar epithelium
  • The wall of the gall bladder is muscular
  • The gall bladder stores bile, when bile is required the muscle wall contracts to push stored bile out
  • External to the muscle of the gall bladder wall, part of the gall bladder is covered with a serosa and part with an adventitia