- The University of Aberdeen Institute of Medical Science, Office 4.63/Lab 4.08
Cell signalling is regulated by two families of proteins, kinases and phosphatases; kinases attach a phosphate group to a protein, and phosphatases remove phosphate groups. Together, these two families of proteins regulate the most critical signalling pathways within cells. While these two families have been studied extensively in a myriad of contexts, currently we have not characterised fully the regulation of myeloid cell function by phosphatases.
My current work focuses on the role of PTP1B in the regulation of dendritic cells during autoimmunity and cancer, with a view to building and independent career studying the effects that illness such as cancer and autoimmunity have on the innate immune system.
I was very honoured to be chosen to take part in the IMS Careers in the Spotlight, where I discussed my path to working in research.
Previously, I have demonstrated that deletion of PTP1B in myeloid cells results in development of de novo Acute Myeloid Leukemia due to constitutive activation of STAT3. I also demonstrated that PTP1B is a crucial regulator of dendritic cell antigen presentation and migration.
In October 2019 I guested on the SciCurious podcast, discussing being a LGBT+ women in academia with a chronic pain condition.
LGBT STEM Village Scotland: Co-Director 2019-202 & Conference Organiser – LGBT STEM Village Conference 2020
500 Women Scientists Aberdeen: Co-Coordinator
Pint of Science 2019 (Brilliant Minds theme): Organiser
Soapbox Scienec 2019: Speaker
LGBT STEM Village Scotland, Co-director, 2019 – Present
NVision Committee member (Publicity and Seminars) 2018 – Present
Scottish Universities Life Sciences Alliance (SULSA) – Early Career Researcher Rep for University of Aberdeen 2018 – Present
Invited Seminar Speaker: April 2019 – NHS Grampian Respiratory Meeting: “Cancer and Autoimmunity – Two Sides of the Same Coin”
Invited Seminar Speaker: Oct 2019 – NHS Grampian Clinical Oncology Meeting: “Dendritic Cells in Cancer – a New Therapeutic Target”
University of Aberdeen, Aberdeen, Scotland
PhD Medicine and Therapeutics (2013-2017).
Thesis: PTP1B is a negative regulator of inflammation in myeloid cells and a tumour suppressor.
Funding: University of Aberdeen Competitive PhD Studentship
University of Edinburgh, Edinburgh, Scotland
BSc in Biological Sciences, with Honours Immunology (2008-2012)
Funding: University of Edinburgh Widening Access Bursary
Clydebank College (now West College Scotland, Clydebank Campus)
Applied Sciences Highers NHD (2006-2008)
2019: Wellcome Trust ISSF Postdoctoral Research Fellowship, University of Aberdeen
2017: Postdoctoral Researcher, University of Aberdeen
Research Grants (Active)
Wellcome Trust (institutional strategic support fund) Postdoctoral Fellowship (2019-2020)
Outreach Grants (Active)
Physiology Society, diversity & outreach grant, (STEM Village Scotland 2020), with Matt Mcsinton (Edinbugh Uni) & Dr Brynley Pearlstone (Glasgow Uni)
FEBS Travel Grant – Europhosphatase 2019
Wellcome Trust (institutional strategic support fund) Seed Corn Fund (2018-2019) co-applicant.
Wellcome Trust Biomedical Summer studentship (2017) supervisor
University of Aberdeen Development Trust (2017-2019) “Regulating inflammation and immunity via myeloid specific PTP1B” Named Researcher.
British Society for Immunology Travel Grant – BSI Congress 2016
Primer Design – Gold Student Sponsorship 2014
Lecturer on MSc Cardiovascular Sciences & Diabetes