Professor Kenneth Forbes

Professor Kenneth Forbes

Personal Chair

Overview
Professor Kenneth Forbes
Professor Kenneth Forbes

Contact Details

Telephone
work +44 (0)1224 437023
Email
Address
The University of Aberdeen  
School of Medicine, Medical Sciences & Nutrition
0:015 Polwarth Building
University of Aberdeen
Foresterhill
Aberdeen, AB25 2ZD, United Kingdom

 
Research

Research Interests

 Our main research interests are in the population genetics of bacterial pathogens of man and have two broad aims: the study of the origins, evolution and diversity of specific bacterial pathogens at the molecular level and improving the control of these pathogens through the application of molecular and epidemiological tools. Recently studies have focused on Mycobacterium tuberculosis, Escherichia coli and Campylobacter.

Mycobacterium tuberculosis is the causative agent of tuberculosis, the greatest cause of mortality in the world due to an infectious agent, indeed one third of the world's population is infected. Why this species apparently has many more genes than current in vitro genomic studies would predict it would need is one of our interests. This species is particularly amenable to phylogenetic experimental approaches and we are examining the commonalities in genome polymorphisms of strains in the different lineages of this species that have caused waves of tuberculosis disease across continents over the evolutionary history of this species. Many of our publications have examined the important role that transposable elements play in the genetic diversification of this species.

Most cases of human enteritis in the developed world are due to sporadic Campylobacter infection, whose epidemiology is poorly understood. We are studying this by identifying cryptic epidemiological links between clinical cases, and between clinical cases and environmental sources of infection, at a national scale.  In a Food Standards Agency- Scotland funded study, CaMPS (Campylobacter MLST Project in Scotland) 5,200 clinical isolates submitted to us by the Scottish NHS diagnostic laboratories and 1,200 food and environmental isolates from across Scotland over a 15-month period, have been typed by the genotypic method of Multilocus Sequence Typing (MLST). This is one of the most extensive studies on Campylobacter epidemiology ever undertaken and the findings are being used to develop strategies for the control Campylobacter infection.

 

Teaching

Teaching Responsibilities

I am the co-ordiator for medical microbiology teaching to early stage students in Medicine and in Dentistry. 

I teach medical microbiology and microbial genetics and evolution to undergraduate and postgraduate students and to students on pre-University access courses.

Publications

Publications 

Currently viewing:

Page 1 of 10 Results 1 to 10 of 91

  • Lopes, BS, Strachan, NJC, Ramjee, M, Thomson, AP, MacRae, M, Shaw, S & Forbes, KJ 2019, 'Nationwide Stepwise Emergence and Evolution of Multidrug-Resistant Campylobacter jejuni Sequence Type 5136, United Kingdom' Emerging Infectious Diseases, vol. 25, no. 7, pp. 1320-1329. [Online] DOI: https://doi.org/10.3201/eid2507.181572
  • Dzianach, PA, Dykes, GA, Strachan, NJC, Forbes, KJ & Pérez-Reche, FJ 2019, 'Challenges of biofilm control and utilization: lessons from mathematical modelling' Journal of the Royal Society Interface, vol. 16, no. 155, 20190042. [Online] DOI: https://doi.org/10.1098/rsif.2019.0042
  • Merget, B, Forbes, KJ, Brennan, F, McAteer, S, Shepherd, T, Strachan, NJC & Holden, NJ 2019, 'Influence of Plant Species, Tissue Type, and Temperature on the Capacity of Shiga-Toxigenic Escherichia coli To Colonize, Grow, and Be Internalized by Plants' Applied and Environmental Microbiology, vol. 85, no. 11, e00123-19. [Online] DOI: https://doi.org/10.1128/AEM.00123-19
  • Painset, A, Björkman, JT, Kiil, K, Guillier, L, Mariet, J-F, Félix, B, Amar, C, Rotariu, O, Roussel, S, Perez-Reche, F, Brisse, S, Moura, A, Lecuit, M, Forbes, K, Strachan, N, Grant, K, Møller-Nielsen, E & Dallman, TJ 2019, 'LiSEQ – whole-genome sequencing of a cross-sectional survey of Listeria monocytogenes in ready-to-eat foods and human clinical cases in Europe' Microbial Genomics, vol. 5, no. 2, 000257. [Online] DOI: https://doi.org/10.1099/mgen.0.000257
  • Rushton, SP, Sanderson, RA, Diggle, PJ, Shirley, MDF, Blain, AP, Lake, I, Maas, JA, Reid, WDK, Hardstaff, J, Williams, N, Jones, NR, Rigby, D, Strachan, NJC, Forbes, KJ, Hunter, PR, Humphrey, TJ & O'Brien, SJ 2019, 'Climate, human behaviour or environment: individual-based modelling of Campylobacter seasonality and strategies to reduce disease burden' Journal of translational medicine, vol. 17, no. 1, 34. [Online] DOI: https://doi.org/10.1186/s12967-019-1781-y
  • Pascoe, B, Williams, LK, Calland, JK, Meric, G, Hitchings, MD, Dyer, M, Ryder, J, Shaw, S, Lopes, BS, Chintoan-Uta, C, Allan, E, Vidal, A, Fearnley, C, Everest, P, Pachebat, JA, Cogan, TA, Stevens, MP, Humphrey, TJ, Wilkinson, TS, Cody, AJ, Colles, FM, Jolley, KA, Maiden, MCJ, Strachan, N, Pearson, BM, Linton, D, Wren, BW, Parkhill, J, Kelly, DJ, van Vliet, AHM, Forbes, KJ & Sheppard, SK 2019, 'Domestication of Campylobacter jejuni NCTC 11168' Microbial Genomics, vol. 5, no. 7, 279. [Online] DOI: https://doi.org/10.1101/591701
  • Franz, E, Rotariu, O, Lopes, BS, MacRae, M, Bono, JL, Laing, CR, Gannon, VPJ, Söderlund, R, van Hoek, AHAM, Friesema, I, French, NP, George, T, Biggs, PJ, Jaros, P, Rivas, M, Chinen, I, Campos, J, Jernberg, C, Gobius, K, Mellor, GE, Chandry, PS, Perez-Reche, F, Forbes, KJ & Strachan, NJC 2019, 'Phylogeographic analysis reveals multiple international transmission events have driven the global emergence of Escherichia coli O157:H7' Clinical Infectious Diseases, vol. 69, no. 3, pp. 428-437. [Online] DOI: https://doi.org/10.1093/cid/ciy919
  • Woodcock, DJ, Krusche, P, Strachan, NJC, Forbes, KJ, Cohan, FM, Méric, G & Sheppard, SK 2017, 'Genomic plasticity and rapid host switching can promote the evolution of generalism: a case study in the zoonotic pathogen Campylobacter' Scientific Reports, vol. 7, 9650. [Online] DOI: https://doi.org/10.1038/s41598-017-09483-9
  • Jones, NR, Millman, C, van der Es, M, Hukelova, M, Forbes, KJ, Glover, C, Haldenby, S, Hunter, PR, Jackson, K, O'Brien, SJ, Rigby, D, Strachan, NJC, Williams, N, Lake, IR & ENIGMA Consortium 2017, 'Novel Sampling Method for Assessing Human-Pathogen Interactions in the Natural Environment Using Boot Socks and Citizen Scientists, with Application to Campylobacter Seasonality' Applied and Environmental Microbiology, vol. 83, no. 14, e00162-17. [Online] DOI: https://doi.org/10.1128/AEM.00162-17
  • Bittaye, M, Cash, P & Forbes, K 2017, 'Proteomic variation and diversity in clinical Streptococcus pneumoniae isolates from invasive and non-invasive sites' PloS ONE, vol. 12, no. 6, e0179075. [Online] DOI: https://doi.org/10.1371/journal.pone.0179075
Show 10 | 25 | 50 | 100 results per page

Update