Honorary Senior Lecturer
- About
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- Email Address
- felix.grassmann@abdn.ac.uk
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I received my PhD in the field of human genetics from the University of Regensburg, Germany. I spent several years as a postdoctoral researcher at the Karolinska Institute in Stockholm, Sweden and was appointed as Senior Lecturer of Bioinformatics and Biostatistics at the Institute of Medical Sciences. Currently, I am a Professor of Epidemiology and the Health and Medical University in Potsdam, Germany as well as a Honorary Senior Lecturer at the IMS in Aberdeen.
Prizes and Awards
2018 Leopoldina Postdoc Fellowship
2016 Travel Grant “RD Meeting Travel Grant” 2016 (Kyoto, Japan)
2016 Pro Retina “Makula-Forschungspreis” (Excellence in Visual Science Award)
2015 Distinguished PhD-Thesis Award (University of Regensburg)
2015 Travel Grant “ARVO Travel Grant“ 2015 (Denver, Colorado, USA)
2012 ProRetina Travel Award (RD Meeting 2012)
2009 Alumni Award University of Regensburg
2009 ProRetina Poster Award
- Research
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Research Overview
The main focus of my research is to understand the inherited and acquired genetics in complex diseases. To this end, I am working with public datasets as well as consortia to generate the largest datasets for each disease of interest. I am particularly interested in diseases with a significant individual and societal burden in aging populations such as age-related macular degeneration, breast cancer and cardiometabolic diseases. My group uses the full spectrum of high-throughput omics tools available to understand the underlying biology behind those diseases with the potential to uncover novel ways to treat of prevent them.
Research Areas
Research Specialisms
- Bioinformatics
- Biomedical Sciences
- Epidemiology
- Human Genetics
- Statistics
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
- Publications
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Page 1 of 3 Results 1 to 25 of 60
Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation
Cell MetabolismContributions to Journals: ArticlesAn ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans
Molecular PsychiatryContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41380-023-02359-7
A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry
Breast Cancer Research, vol. 25, no. 1, pp. 93Contributions to Journals: ArticlesLow leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study
Cardiovascular Research, vol. 119, no. 4, pp. 998-1007Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/cvr/cvac182
The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses
Atherosclerosis, vol. 354, pp. 1-7Contributions to Journals: ArticlesSeed sequence polymorphism rs2168518 and allele-specific target gene regulation of hsa-miR-4513
Human Molecular Genetics, vol. 31, no. 6, pp. 875-887Contributions to Journals: ArticlesCYP2D6 genotype predicts tamoxifen discontinuation and drug response: a secondary analysis of the KARISMA trial
Annals of Oncology, vol. 32, no. 10, pp. 1286-1293Contributions to Journals: ArticlesLymph node metastases in breast cancer: investigating associations with tumor characteristics, molecular subtypes, and polygenic risk score using a continuous growth model
International Journal of Cancer, vol. 149, no. 6, pp. 1348-1357Contributions to Journals: ArticlesMammographic features are associated with cardiometabolic disease risk and mortality
European Heart Journal, vol. 42, no. 34, pp. 3361–3370Contributions to Journals: ArticlesDeciphering the genetic and epidemiological landscape of mitochondrial DNA abundance
Human Genetics, vol. 140, pp. 849-861Contributions to Journals: ArticlesAssociation between breast cancer risk and disease aggressiveness: Characterizing underlying gene expression patterns
International Journal of Cancer, vol. 148, no. 4, pp. 884-894Contributions to Journals: ArticlesPleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)
Cells, vol. 9, no. 10, 2257Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/cells9102257
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15353/1/Kiel_PlleiotropicLens_VOR.pdf
- [ONLINE] View publication in Scopus
The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival: the Malmö Diet and Cancer Study
Acta radiologica (Stockholm, Sweden : 1987), vol. 61, no. 10, pp. 1326-1334Contributions to Journals: ArticlesA mega-analysis of expression quantitative trait loci in retinal tissue
PLoS Genetics, vol. 16, no. 9, pp. e1008934Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pgen.1008934
- [ONLINE] View publication in Scopus
Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease
BMC Medical Genomics, vol. 13, 120Contributions to Journals: ArticlesA Circulating MicroRNA Profile in a Laser-Induced Mouse Model of Choroidal Neovascularization
International Journal of Molecular Sciences, vol. 21, no. 8, 2689Contributions to Journals: ArticlesInsights into the loss of the Y chromosome with age in control individuals and in patients with age-related macular degeneration using genotyping microarray data
Human Genetics, vol. 139, pp. 401-407Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00439-019-02029-1
- [ONLINE] View publication in Scopus
CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer
Journal of Clinical Oncology, vol. 38, no. 6, pp. 548-557Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1200/JCO.19.01535
- [ONLINE] View publication in Scopus
Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial
Ophthalmology, vol. 127, no. 2, pp. 186-195Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ophtha.2019.07.011
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14537/1/Liao_AAO_Complement_VOR.pdf
- [ONLINE] View publication in Scopus
A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration
Scientific Reports, vol. 10, 1584Contributions to Journals: ArticlesInterval breast cancer is associated with other types of tumors
Nature Communications, vol. 10, 4648Contributions to Journals: ArticlesCost-effective molecular inversion probe-based ABCA4 sequencing reveals deep-intronic variants in Stargardt disease
Human Mutation, vol. 40, no. 10, pp. 1749-1759Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/humu.23787
- [ONLINE] View publication in Scopus
Deep-intronic ABCA4 variants explain missing heritability in Stargardt disease and allow correction of splice defects by antisense oligonucleotides
Genetics in Medicine, vol. 21, no. 8, pp. 1751-1760Contributions to Journals: ArticlesThe agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia
Journal of Neuroinflammation, vol. 16, 43Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12974-019-1424-5
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14979/1/Mages_etal_JN_Agonistic_VOR.pdf
- [ONLINE] View publication in Scopus
Conduct and Quality Control of Differential Gene Expression Analysis Using High-Throughput Transcriptome Sequencing (RNASeq)
Methods in Molecular Biology. HUMANA PRESS INC, pp. 29-43, 15 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-1-4939-8669-9_2
- [ONLINE] View publication in Scopus