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The Institute of Medical Sciences

Dr Felix Grassmann

Dr Felix Grassmann
Dr Felix Grassmann
Dr Felix Grassmann

Honorary Senior Lecturer

About
Email Address
felix.grassmann@abdn.ac.uk
Office Address
Institute of Medical Sciences
Foresterhill Campus
Ashgrove Road West
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition
Personal Website

Biography

I received my PhD in the field of human genetics from the University of Regensburg, Germany. I spent several years as a postdoctoral researcher at the Karolinska Institute in Stockholm, Sweden and was appointed as Senior Lecturer of Bioinformatics and Biostatistics at the Institute of Medical Sciences. Currently, I am a Professor of Epidemiology and the Health and Medical University in Potsdam, Germany as well as a Honorary Senior Lecturer at the IMS in Aberdeen.

Prizes and Awards

2018               Leopoldina Postdoc Fellowship

2016               Travel Grant “RD Meeting Travel Grant” 2016 (Kyoto, Japan)

2016               Pro Retina “Makula-Forschungspreis” (Excellence in Visual Science Award)

2015               Distinguished PhD-Thesis Award (University of Regensburg)

2015              Travel Grant “ARVO Travel Grant“ 2015 (Denver, Colorado, USA)

2012             ProRetina Travel Award (RD Meeting 2012)

2009             Alumni Award University of Regensburg

2009             ProRetina Poster Award

Research

Research Overview

The main focus of my research is to understand the inherited and acquired genetics in complex diseases. To this end, I am working with public datasets as well as consortia to generate the largest datasets for each disease of interest. I am particularly interested in diseases with a significant individual and societal burden in aging populations such as age-related macular degeneration, breast cancer and cardiometabolic diseases. My group uses the full spectrum of high-throughput omics tools available to understand the underlying biology behind those diseases with the potential to uncover novel ways to treat of prevent them.

Research Areas

Biomedical Sciences

Supervising
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Applied Health Sciences

Supervising
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Research Specialisms

  • Bioinformatics
  • Biomedical Sciences
  • Epidemiology
  • Human Genetics
  • Statistics

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Publications

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  • Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation

    Leeson-Payne, A., Iyinikkel, J., Malcolm, C., Lam, B. Y. H., Sommer, N., Dowsett, G. K. C., Blanco Martinez de Morentin, P., Thompson, D., MacKenzie, A., Chianese, R., Kentistou, K. A., Gardner, E. J., Perry, J. R., Grassmann, F., Speakman, J., Rochford, J., Yeo, G. S. H., Murray, F., Heisler, L.
    Cell Metabolism
    Contributions to Journals: Articles

  • An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans

    McEwan, A. R., Hing, B., Erickson, J. C., Hutchings, G., Urama, C., Norton-Hughes, E., D'Ippolito, M., Berry, S., Delibegovic, M., Grassmann, F., MacKenzie, A.
    Molecular Psychiatry
    Contributions to Journals: Articles

  • A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

    Middha, P., Wang, X., Behrens, S., Bolla, M. K., Wang, Q., Dennis, J., Michailidou, K., Ahearn, T. U., Andrulis, I. L., Anton-Culver, H., Arndt, V., Aronson, K. J., Auer, P. L., Augustinsson, A., Baert, T., Freeman, L. E. B., Becher, H., Beckmann, M. W., Benitez, J., Bojesen, S. E., Brauch, H., Brenner, H., Brooks-Wilson, A., Campa, D., Canzian, F., Carracedo, A., Castelao, J. E., Chanock, S. J., Chenevix-Trench, G., Cordina-Duverger, E., Couch, F. J., Cox, A., Cross, S. S., Czene, K., Dossus, L., Dugué, P., Eliassen, A. H., Eriksson, M., Evans, D. G., Fasching, P. A., Figueroa, J. D., Fletcher, O., Flyger, H., Gabrielson, M., Gago-Dominguez, M., Giles, G. G., González-Neira, A., Grassmann, F., Grundy, A., Guénel, P., CTS Consortium
    Breast Cancer Research, vol. 25, no. 1, pp. 93
    Contributions to Journals: Articles

  • Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study

    Luo, J., Noordam, R., Jukema, J. W., Willems van Dijk, K., Hägg, S., Grassmann, F., le Cessie, S., van Heemst, D.
    Cardiovascular Research, vol. 119, no. 4, pp. 998-1007
    Contributions to Journals: Articles

  • The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses

    Martens, L. G., Luo, J., Wermer, M. J. H., Willems van Dijk, K., Hägg, S., Grassmann, F., Noordam, R., van Heemst, D.
    Atherosclerosis, vol. 354, pp. 1-7
    Contributions to Journals: Articles

  • Seed sequence polymorphism rs2168518 and allele-specific target gene regulation of hsa-miR-4513

    Kiel, C., Strunz, T., Hasler, D., Meister, G., Grassmann, F., Weber, B. H. F.
    Human Molecular Genetics, vol. 31, no. 6, pp. 875-887
    Contributions to Journals: Articles

  • CYP2D6 genotype predicts tamoxifen discontinuation and drug response: a secondary analysis of the KARISMA trial

    He, W., Eriksson, M., Eliasson, E., Grassmann, F., Bäcklund, M., Gabrielson, M., Hammarström, M., Margolin, S., Thorén, L., Wengström, Y., Borgquist, S., Hall, P., Czene, K.
    Annals of Oncology, vol. 32, no. 10, pp. 1286-1293
    Contributions to Journals: Articles

  • Lymph node metastases in breast cancer: investigating associations with tumor characteristics, molecular subtypes, and polygenic risk score using a continuous growth model

    Isheden, G., Grassmann, F., Czene, K., Humphreys, K.
    International Journal of Cancer, vol. 149, no. 6, pp. 1348-1357
    Contributions to Journals: Articles

  • Mammographic features are associated with cardiometabolic disease risk and mortality

    Grassmann, F., Yang, H., Eriksson, M., Azam, S., Hall, P., Czene, K.
    European Heart Journal, vol. 42, no. 34, pp. 3361–3370
    Contributions to Journals: Articles

  • Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance

    Hägg, S., Jylhävä, J., Wang, Y., Czene, K., Grassmann, F.
    Human Genetics, vol. 140, pp. 849-861
    Contributions to Journals: Articles

  • Association between breast cancer risk and disease aggressiveness: Characterizing underlying gene expression patterns

    Ugalde-Morales, E., Grassmann, F., Humphreys, K., Li, J., Eriksson, M., Tobin, N. P., Borg, ?., Vallon-Christersson, J., Hall, P., Czene, K.
    International Journal of Cancer, vol. 148, no. 4, pp. 884-894
    Contributions to Journals: Articles

  • Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)

    Kiel, C., International AMD Genomics Consortium (IAMDGC), Strunz, T., Grassmann, F., Weber, B. H.
    Cells, vol. 9, no. 10, 2257
    Contributions to Journals: Articles

  • The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival: the Malmö Diet and Cancer Study

    Sartor, H., Brandt, J., Grassmann, F., Eriksson, M., Czene, K., Melander, O., Zackrisson, S.
    Acta radiologica (Stockholm, Sweden : 1987), vol. 61, no. 10, pp. 1326-1334
    Contributions to Journals: Articles

  • A mega-analysis of expression quantitative trait loci in retinal tissue

    Strunz, T., Kiel, C., Grassmann, F., Ratnapriya, R., Kwicklis, M., Karlstetter, M., Fauser, S., Arend, N., Swaroop, A., Langmann, T., Wolf, A., Weber, B. H. F.
    PLoS Genetics, vol. 16, no. 9, pp. e1008934
    Contributions to Journals: Articles

  • Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

    Winkler, T. W., Grassmann, F., Brandl, C., Kiel, C., Günther, F., Strunz, T., Weidner, L., Zimmermann, M. E., Korb, C. A., Poplawski, A., Schuster, A. K., Müller-Nurasyid, M., Peters, A., Rauscher, F. G., Elze, T., Horn, K., Scholz, M., Cañadas-Garre, M., McKnight, A. J., Quinn, N., Hogg, R. E., Küchenhoff, H., Heid, I. M., Stark, K. J., Weber, B. H. F.
    BMC Medical Genomics, vol. 13, 120
    Contributions to Journals: Articles

  • A Circulating MicroRNA Profile in a Laser-Induced Mouse Model of Choroidal Neovascularization

    Kiel, C., Berber, P., Karlstetter, M., Aslanidis, A., Strunz, T., Langmann, T., Grassmann, F., Weber, B. H. F.
    International Journal of Molecular Sciences, vol. 21, no. 8, 2689
    Contributions to Journals: Articles

  • Insights into the loss of the Y chromosome with age in control individuals and in patients with age-related macular degeneration using genotyping microarray data

    Grassmann, F., Weber, B. H., Veitia, R. A., International AMD Genomics Consortium (IAMDGC)
    Human Genetics, vol. 139, pp. 401-407
    Contributions to Journals: Articles

  • CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer

    He, W., Grassmann, F., Eriksson, M., Eliasson, E., Margolin, S., Thorén, L., Hall, P., Czene, K.
    Journal of Clinical Oncology, vol. 38, no. 6, pp. 548-557
    Contributions to Journals: Articles

  • Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial

    Liao, D. S., Grossi, F. V., El Mehdi, D., Gerber, M. R., Brown, D. M., Heier, J. S., Wykoff, C. C., Singerman, L. J., Abraham, P., Grassmann, F., Nuernberg, P., Weber, B. H. F., Deschatelets, P., Kim, R. Y., Chung, C. Y., Ribeiro, R. M., Hamdani, M., Rosenfeld, P. J., Boyer, D. S., Slakter, J. S., Francois, C. G.
    Ophthalmology, vol. 127, no. 2, pp. 186-195
    Contributions to Journals: Articles

  • A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

    Strunz, T., Lauwen, S., Kiel, C., Hollander, A. d., Weber, B. H. F., International AMD Genomics Consortium (IAMDGC), Grassmann, F.
    Scientific Reports, vol. 10, 1584
    Contributions to Journals: Articles

  • Interval breast cancer is associated with other types of tumors

    Grassmann, F., He, W., Eriksson, M., Gabrielson, M., Hall, P., Czene, K.
    Nature Communications, vol. 10, 4648
    Contributions to Journals: Articles

  • Cost-effective molecular inversion probe-based ABCA4 sequencing reveals deep-intronic variants in Stargardt disease

    Khan, M., Cornelis, S. S., Khan, M. I., Elmelik, D., Manders, E., Bakker, S., Derks, R., Neveling, K., van de Vorst, M., Gilissen, C., Meunier, I., Defoort, S., Puech, B., Devos, A., Schulz, H. L., Stöhr, H., Grassmann, F., Weber, B. H., Dhaenens, C. M., Cremers, F. P.
    Human Mutation, vol. 40, no. 10, pp. 1749-1759
    Contributions to Journals: Articles

  • Deep-intronic ABCA4 variants explain missing heritability in Stargardt disease and allow correction of splice defects by antisense oligonucleotides

    Sangermano, R., Garanto, A., Khan, M., Runhart, E. H., Bauwens, M., Bax, N. M., van den Born, L. I., Khan, M. I., Cornelis, S. S., Verheij, J. B., Pott, J. W. R., Thiadens, A. A., Klaver, C. C., Puech, B., Meunier, I., Naessens, S., Arno, G., Fakin, A., Carss, K. J., Raymond, F. L., Webster, A. R., Dhaenens, C. M., Stöhr, H., Grassmann, F., Weber, B. H., Hoyng, C. B., De Baere, E., Albert, S., Collin, R. W., Cremers, F. P.
    Genetics in Medicine, vol. 21, no. 8, pp. 1751-1760
    Contributions to Journals: Articles

  • The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia

    Mages, K., Grassmann, F., Jägle, H., Rupprecht, R., Weber, B. H., Hauck, S. M., Grosche, A.
    Journal of Neuroinflammation, vol. 16, 43
    Contributions to Journals: Articles

  • Conduct and Quality Control of Differential Gene Expression Analysis Using High-Throughput Transcriptome Sequencing (RNASeq)

    Grassmann, F.
    Methods in Molecular Biology. HUMANA PRESS INC, pp. 29-43, 15 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Y chromosome mosaicism is associated with age-related macular degeneration

    Grassmann, F., Kiel, C., den Hollander, A. I., Weeks, D. E., Lotery, A., Cipriani, V., Weber, B. H., on behalf of the International Age-related Macular Degeneration Genomics Consortium (IAMDGC)
    European Journal of Human Genetics, vol. 27, pp. 36-41
    Contributions to Journals: Articles

  • Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration

    Grassmann, F., Harsch, S., Brandl, C., Kiel, C., Nürnberg, P., Toliat, M. R., Fleckenstein, M., Pfau, M., Schmitz-Valckenberg, S., Holz, F. G., Chew, E. Y., Swaroop, A., Ratnapriya, R., Klein, M. L., Mulyukov, Z., Zamiri, P., Weber, B. H.
    JAMA Ophthalmology, vol. 137, no. 8, pp. 867-876
    Contributions to Journals: Articles

  • Spectral domain optical coherence tomography allows the unification of clinical decision making for the evaluation of choroidal neovascularization activity

    Volz, C., Grassmann, F., Greslechner, R., Märker, D. A., Peters, P., Helbig, H., Gamulescu, M. A.
    Ophthalmologica, vol. 241, no. 1, pp. 32-37
    Contributions to Journals: Articles

  • Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration

    Pujol-Lereis, L. M., Liebisch, G., Schick, T., Lin, Y., Grassmann, F., Uchida, K., Zipfel, P. F., Fauser, S., Skerka, C., Weber, B. H.
    PloS ONE, vol. 13, no. 8, e0200739
    Contributions to Journals: Articles

  • Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H (CFH) gene family

    Cantsilieris, S., Nelson, B. J., Huddleston, J., Baker, C., Harshman, L., Penewit, K., Munson, K. M., Sorensen, M., Welch, A. M. E., Dang, V., Grassmann, F., Richardson, A. J., Guymer, R. H., Graves-Lindsay, T. A., Wilson, R. K., Weber, B. H., Baird, P. N., Allikmets, R., Eichler, E. E.
    Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 19, pp. E4433-E4442
    Contributions to Journals: Articles

  • Pleiotropic effects of risk factors in age-related macular degeneration and seemingly unrelated complex diseases

    Kiel, C., Weber, B. H., Grassmann, F.
    Retinal Degenerative Diseases. Ash, J. D., Anderson, R. E., LaVail, M. M., Rickman, C. B., Hollyfield, J. G. (eds.). Springer New York LLC, pp. 247-255, 9 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver

    Strunz, T., Grassmann, F., Gayán, J., Nahkuri, S., Souza-Costa, D., Maugeais, C., Fauser, S., Nogoceke, E., Weber, B. H.
    Scientific Reports, vol. 8, 5865
    Contributions to Journals: Articles

  • A Deep Learning Algorithm for Prediction of Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration from Color Fundus Photography

    Grassmann, F., Mengelkamp, J., Brandl, C., Harsch, S., Zimmermann, M. E., Linkohr, B., Peters, A., Heid, I. M., Palm, C., Weber, B. H.
    Ophthalmology, vol. 125, no. 9, pp. 1410-1420
    Contributions to Journals: Articles

  • Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci

    Winkler, T. W., Brandl, C., Grassmann, F., Gorski, M., Stark, K., Loss, J., Weber, B. H., Heid, I. M., International Age-related Macular Degeneration Genomics Consortium (IAMDGC)
    PloS ONE, vol. 13, no. 3, e0194321
    Contributions to Journals: Articles

  • Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

    Grassmann, F., Kiel, C., Zimmermann, M. E., Gorski, M., Grassmann, V., Stark, K., Heid, I. M., Weber, B. H., Fritsche, L. G., Igl, W., Bailey, J. N., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Kim, I. K., Cho, D., Zack, D., Souied, E., Scholl, H. P., Bala, E., Lee, K. E., Hunter, D. J., Sardell, R. J., Mitchell, P., Merriam, J. E., Cipriani, V., Hoffman, J. D., Schick, T., Lechanteur, Y. T., Guymer, R. H., Johnson, M. P., Jiang, Y., Stanton, C. M., Buitendijk, G. H., Zhan, X., Kwong, A. M., Boleda, A., Brooks, M., Gieser, L., Ratnapriya, R., Branham, K. E., Foerster, J. R., Heckenlively, J. R., Othman, M. I., Vote, B. J., Liang, H. H., Souzeau, E., McAllister, I. L., International AMD Genomics Consortium (IAMDGC)
    Genome Medicine, vol. 9, 29
    Contributions to Journals: Articles

  • Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration

    Grassmann, F., Heid, I. M., Weber, B. H., Fritsche, L. G., Igl, W., Bailey, J. N., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., Kim, I. K., Cho, D., Zack, D., Souied, E., Scholl, H. P., Bala, E., Lee, K. E., Hunter, D. J., Sardell, R. J., Mitchell, P., Merriam, J. E., Cipriani, V., Hoffman, J. D., Schick, T., Lechanteur, Y. T., Guymer, R. H., Johnson, M. P., Jiang, Y., Stanton, C. M., Buitendijk, G. H., Zhan, X., Kwong, A. M., Boleda, A., Brooks, M., Gieser, L., Ratnapriya, R., Branham, K. E., Foerster, J. R., Heckenlively, J. R., Othman, M. I., Vote, B. J., Liang, H. H., Souzeau, E., McAllister, I. L., Isaacs, T., Hall, J., Lake, S., International AMD Genomics Consortium (IAMDGC)
    Genetics, vol. 205, no. 2, pp. 919-924
    Contributions to Journals: Articles

  • Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator

    Micklisch, S., Lin, Y., Jacob, S., Karlstetter, M., Dannhausen, K., Dasari, P., von der Heide, M., Dahse, H. M., Schmölz, L., Grassmann, F., Alene, M., Fauser, S., Neumann, H., Lorkowski, S., Pauly, D., Weber, B. H., Joussen, A. M., Langmann, T., Zipfel, P. F., Skerka, C.
    Journal of Neuroinflammation, vol. 14, 4
    Contributions to Journals: Articles

  • Mutation spectrum of the ABCA4 gene in 335 stargardt disease patients from a multicenter German cohort—impact of selected deep intronic variants and common SNPs

    Schulz, H. L., Grassmann, F., Kellner, U., Spital, G., Rüther, K., Jägle, H., Hufendiek, K., Rating, P., Huchzermeyer, C., Baier, M. J., Weber, B. H., Stöhr, H.
    Investigative Ophthalmology and Visual Science, vol. 58, no. 1, pp. 394-403
    Contributions to Journals: Articles

  • An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology

    Berber, P., Grassmann, F., Kiel, C., Weber, B. H.
    Molecular Diagnosis and Therapy, vol. 21, no. 1, pp. 31-43
    Contributions to Journals: Review articles

  • Genetische Risiken und Therapieentwicklung bei Netzhautdegenerationen

    Grassmann, F., Weber, B.
    Medizinische Genetik, vol. 29, no. 2, pp. 195-201
    Contributions to Journals: Review articles

  • Features of age-related macular degeneration in the general adults and their dependency on age, sex, and smoking: Results from the German KORA study

    Brandl, C., Breinlich, V., Stark, K. J., Enzinger, S., Aenmacher, M., Olden, M., Grassmann, F., Graw, J., Heier, M., Peters, A., Helbig, H., Küchenhoff, H., Weber, B. H., Heid, I. M.
    PloS ONE, vol. 11, no. 11, e0167181
    Contributions to Journals: Articles

  • Distinct genetic risk profile of the rapidly progressing diffuse-trickling subtype of geographic atrophy in age-related macular degeneration (AMD)

    Fleckenstein, M., Grassmann, F., Lindner, M., Pfau, M., Czauderna, J., Strunz, T., von Strachwitz, C., Schmitz-Valckenberg, S., Holz, F. G., Weber, B. H.
    Investigative Ophthalmology and Visual Science, vol. 57, no. 6, pp. 2463-2471
    Contributions to Journals: Articles

  • Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)

    Grassmann, F., Cantsilieris, S., Schulz-Kuhnt, A. S., White, S. J., Richardson, A. J., Hewitt, A. W., Vote, B. J., Schmied, D., Guymer, R. H., Weber, B. H., Baird, P. N.
    Journal of Neuroinflammation, vol. 13, 81
    Contributions to Journals: Articles

  • A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

    Fritsche, L. G., Igl, W., Bailey, J. N., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., Kim, I. K., Cho, D., Zack, D., Souied, E., Scholl, H. P., Bala, E., ELee, K., Hunter, D. J., Sardell, R. J., Mitchell, P., Merriam, J. E., Cipriani, V., Hoffman, J. D., Schick, T., Lechanteur, Y. T., Guymer, R. H., Johnson, M. P., Jiang, Y., Stanton, C. M., Buitendijk, G. H., Zhan, X., Kwong, A. M., Boleda, A., Brooks, M., Gieser, L., Ratnapriya, R., Branham, K. E., Foerster, J. R., Heckenlively, J. R., Othman, M. I., Vote, B. J., Liang, H. H., Souzeau, E., McAllister, I. L., Isaacs, T., Hall, J., Lake, S., Mackey, D. A., Constable, I. J., Craig, J. E., Kitchner, T. E., Yang, Z., Su, Z., Luo, H., Chen, D., Ouyang, H., Flagg, K., Lin, D., Mao, G., Ferreyra, H., Stark, K., Von Strachwitz, C. N., Wolf, A., Brandl, C., Rudolph, G., Olden, M., Morrison, M. A., Morgan, D. J., Schu, M., Ahn, J., Silvestri, G., Tsironi, E. E., Park, K. H., Farrer, L. A., Orlin, A., Brucker, A., Li, M., Curcio, C. A., Mohand-Sa'd, S., Sahel, J. A., Audo, I., Benchaboune, M., Cree, A. J., Rennie, C. A., Goverdhan, S. V., Grunin, M., Hagbi-Levi, S., Campochiaro, P., Katsanis, N., Holz, F. G., Blond, F., Blanché, H., Deleuze, J. F. o., Igo, R. P., Truitt, B., Peachey, N. S., Meuer, S. M., Myers, C. E., Moore, E. L., Klein, R., Hauser, M. A., Postel, E. A., Courtenay, M. D., Schwartz, S. G., Kovach, J. L., Scott, W. K., Liew, G., Tan, A. G., Gopinath, B., Merriam, J. C., Smith, R. T., Khan, J. C., Shahid, H., Moore, A. T., McGrath, J. A., Laux, R., Brantley, M. A., Agarwal, A., Ersoy, L., Caramoy, A., Langmann, T., Saksens, N. T., Jong, E. K., Hoyng, C. B., Cain, M. S., Richardson, A. J., Martin, T. M., Blangero, J., Weeks, D. E., Dhillon, B., Van Duijn, C. M., Doheny, K. F., Romm, J., Klaver, C. C., Hayward, C., Gorin, M. B., Klein, M. L., Baird, P. N., Den Hollander, A. I., Fauser, S., Yates, J. R., Allikmets, R., Wang, J. J., Schaumberg, D. A., Klein, B. E., Hagstrom, S. A., Chowers, I., Lotery, A. J., Léveillard, T., Zhang, K., Brilliant, M. H., Hewitt, A. W., Swaroop, A., Chew, E. Y., Pericak-Vance, M. A., DeAngelis, M., Stambolian, D., Haines, J. L., Iyengar, S. K., Weber, B. H., Abecasis, G. R., Heid, I. M.
    Nature Genetics, vol. 48, pp. 134-143
    Contributions to Journals: Articles

  • Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-βsignaling

    Friedrich, U., Datta, S., Schubert, T., Plössl, K., Schneider, M., Grassmann, F., Fuchshofer, R., Tiefenbach, K. J., Längst, G., Weber, B. H.
    Human Molecular Genetics, vol. 24, no. 22, pp. 6361-6373
    Contributions to Journals: Articles

  • Genetisches Risiko bei der altersabhängigen Makuladegeneration

    Grassmann, F., Loss, J., Heid, I. M., Weber, B. H.
    BioSpektrum, vol. 21, no. 7, pp. 703-705
    Contributions to Journals: Articles

  • What Does Genetics Tell Us About Age-Related Macular Degeneration?

    Grassmann, F., Ach, T., Brandl, C., Heid, I., Weber, B.
    Annual review of vision science, vol. 1, pp. 73-96
    Contributions to Journals: Articles

  • The genetics of age-related macular degeneration (AMD) - Novel targets for designing treatment options?

    Grassmann, F., Fauser, S., Weber, B. H.
    European Journal of Pharmaceutics and Biopharmaceutics, vol. 95, no. Part B, pp. 194-202
    Contributions to Journals: Articles

  • A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD)

    Grassmann, F., Friedrich, U., Fauser, S., Schick, T., Milenkovic, A., Schulz, H. L., von Strachwitz, C. N., Bettecken, T., Lichtner, P., Meitinger, T., Arend, N., Wolf, A., Haritoglou, C., Rudolph, G., Chakravarthy, U., Silvestri, G., McKay, G. J., Freitag-Wolf, S., Krawczak, M., Smith, R. T., Merriam, J. C., Merriam, J. E., Allikmets, R., Heid, I. M., Weber, B. H.
    NeuroMolecular Medicine, vol. 17, no. 2, pp. 111-120
    Contributions to Journals: Articles

  • Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration

    Grassmann, F., Fleckenstein, M., Chew, E. Y., Strunz, T., Schmitz-Valckenberg, S., Göbel, A. P., Klein, M. L., Ratnapriya, R., Swaroop, A., Holz, F. G., Weber, B. H.
    PloS ONE, vol. 10, no. 5, e0126636
    Contributions to Journals: Articles

  • Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy) Neuro-ophthalmology

    Grassmann, F., Bergholz, R., Mändl, J., Jägle, H., Ruether, K., Weber, B. H.
    BMC Ophthalmology, vol. 15, 18
    Contributions to Journals: Articles

  • Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration

    Ratnapriya, R., Zhan, X., Fariss, R. N., Branham, K. E., Zipprer, D., Chakarova, C. F., Sergeev, Y. V., Campos, M. M., Othman, M., Friedman, J. S., Maminishkis, A., Waseem, N. H., Brooks, M., Rajasimha, H. K., Edwards, A. O., Lotery, A., Klein, B. E., Truitt, B. J., Li, B., Schaumberg, D. A., Morgan, D. J., Morrison, M. A., Souied, E., Tsironi, E. E., Grassmann, F., Fishman, G. A., Silvestri, G., Scholl, H. P., Kim, I. K., Ramke, J., Tuo, J., Merriam, J. E., Merriam, J. C., Park, K. H., Olson, L. M., Farrer, L. A., Johnson, M. P., Peachey, N. S., Lathrop, M., Baron, R. V., Igo, R. P., Klein, R., Hagstrom, S. A., Kamatani, Y., Martin, T. M., Jiang, Y., Conley, Y., Sahel, J. A., Zack, D. J., Chan, C. C., Pericak-Vance, M. A., Jacobson, S. G., Gorin, M. B., Klein, M. L., Allikmets, R., Iyengar, S. K., Weber, B. H., Haines, J. L., Léveillard, T., Deangelis, M. M., Stambolian, D., Weeks, D. E., Bhattacharya, S. S., Chew, E. Y., Heckenlively, J. R., Abecasis, G. R., Swaroop, A.
    Human Molecular Genetics, vol. 23, no. 21, pp. 5827-5837
    Contributions to Journals: Articles

  • A circulating MicroRNA profile is associated with late- stage neovascular age-related macular degeneration

    Grassmann, F., Schoenberger, P. G., Brandl, C., Schick, T., Hasler, D., Meister, G., Fleckenstein, M., Lindner, M., Helbig, H., Fauser, S., Weber, B. H.
    PloS ONE, vol. 9, no. 9, e0107461
    Contributions to Journals: Articles

  • In-depth characterisation of retinal pigment epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC)

    Brandl, C., Zimmermann, S. J., Milenkovic, V. M., Rosendahl, S. M., Grassmann, F., Milenkovic, A., Hehr, U., Federlin, M., Wetzel, C. H., Helbig, H., Weber, B. H.
    NeuroMolecular Medicine, vol. 16, no. 3, pp. 551-564
    Contributions to Journals: Articles

  • Bedeutung des komplementsystems für die altersabhängige makuladegeneration

    Weber, B. H., Charbel Issa, P., Pauly, D., Herrmann, P., Grassmann, F., Holz, F. G.
    Deutsches Arzteblatt International, vol. 111, no. 8, pp. 133-138
    Contributions to Journals: Articles

  • Genetic risk models in age-related macular degeneration

    Grassmann, F., Heid, I. M., Weber, B. H.
    Advances in Experimental Medicine and Biology, vol. 801, pp. 291-300
    Contributions to Journals: Articles

  • Identification of a rare coding variant in complement 3 associated with age-related macular degeneration

    Zhan, X., Larson, D. E., Wang, C., Koboldt, D. C., Sergeev, Y. V., Fulton, R. S., Fulton, L. L., Fronick, C. C., Branham, K. E., Bragg-Gresham, J., Jun, G., Hu, Y., Kang, H. M., Liu, D., Othman, M., Brooks, M., Ratnapriya, R., Boleda, A., Grassmann, F., Von Strachwitz, C., Olson, L. M., Buitendijk, G. H., Hofman, A., Van Duijn, C. M., Cipriani, V., Moore, A. T., Shahid, H., Jiang, Y., Conley, Y. P., Morgan, D. J., Kim, I. K., Johnson, M. P., Cantsilieris, S., Richardson, A. J., Guymer, R. H., Luo, H., Ouyang, H., Licht, C., Pluthero, F. G., Zhang, M. M., Zhang, K., Baird, P. N., Blangero, J., Klein, M. L., Farrer, L. A., DeAngelis, M. M., Weeks, D. E., Gorin, M. B., Yates, J. R., Klaver, C. C., Pericak-Vance, M. A., Haines, J. L., Weber, B. H., Wilson, R. K., Heckenlively, J. R., Chew, E. Y., Stambolian, D., Mardis, E. R., Swaroop, A., Abecasis, G. R.
    Nature Genetics, vol. 45, no. 11, pp. 1375-1379
    Contributions to Journals: Letters

  • The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association

    Zach, F., Grassmann, F., Langmann, T., Sorusch, N., Wolfrum, U., Stöhr, H.
    Human Molecular Genetics, vol. 21, no. 21, pp. 4573-4586
    Contributions to Journals: Articles

  • Modelling the genetic risk in age-related macular degeneration

    Grassmann, F., Fritsche, L. G., Keilhauer, C. N., Heid, I. M., Weber, B. H.
    PloS ONE, vol. 7, no. 5, e37979
    Contributions to Journals: Articles

  • Wie groß sind die kleinen genetischen Risiken?

    Heid, I. M., Winkler, T. W., Grassmann, F., Weber, B. H.
    Medizinische Genetik, vol. 23, no. 3, pp. 377-384
    Contributions to Journals: Articles

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