Professor David St Clair

Professor David St Clair

Chair in Applied Medicine

Overview

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Research

Research Overview

Psychiatric Genetics, particularly of schizophrenia.

Publications

Publications 

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  • Rare CNVs and tag SNPs at 15q11.2 are associated with schizophrenia in the Han Chinese population

    Zhao, Q., Li, T., Zhao, X., Huang, K., Wang, T., Li, Z., Ji, J., Zeng, Z., Zhang, Z., Li, K., Feng, G., St Clair, D., He, L., Shi, Y.

    Schizophrenia Bulletin, vol. 39, no. 3, pp. 712-719

    Contributions to Journals: Articles

  • Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease

    Huertas-Vazquez, A., Nelson, C. P., Guo, X., Reinier, K., Uy-Evanado, A., Teodorescu, C., Ayala, J., Jerger, K., Chugh, H., Braund, P. S., Deloukas, P., Hall, A. S., Balmforth, A. J., Jones, M., Taylor, K. D., Pulit, S. L., Newton-Cheh, C., Gunson, K., Jui, J., Rotter, J. I., Albert, C. M., Samani, N. J., Chugh, S. S., Aerts, J., Ahmad, T., Arbury, H., Attwood, A., Auton, A., Ball, S. G., Balmforth, A. J., Barnes, C., Barrett, J. C., Barroso, I., Barton, A., Bennett, A. J., Bhaskar, S., Blaszczyk, K., Bowes, J., Brand, O. J., Braund, P. S., Bredin, F., Breen, G., Brown, M. J., Bruce, I. N., Bull, J., Burren, O. S., Burton, J., Hocking, L., Reid, D. M., St Clair, D., WTCCC+

    PloS ONE, vol. 8, no. 4, e59905

    Contributions to Journals: Articles

  • Simple viewing tests can detect eye movement abnormalities that distinguish schizophrenia cases from controls with exceptional accuracy

    Benson, P. J., Beedie, S. A., Shephard, E., Giegling, I., Rujescu, D., St Clair, D.

    Biological Psychiatry, vol. 72, no. 9, pp. 716-724

    Contributions to Journals: Articles

  • Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder

    Vassos, E., Steinberg, S., Cichon, S., Breen, G., Sigurdsson, E., Andreassen, O. A., Djurovic, S., Morken, G., Grigoroiu-Serbanescu, M., Diaconu, C. C., Czerski, P. M., Hauser, J., Babadjanova, G., Abramova, L. I., Mühleisen, T. W., Nöthen, M. M., Rietschel, M., McGuffin, P., Clair, D. S., Gustafsson, O., Melle, I., Pietiläinen, O. P. H., Ruggeri, M., Tosato, S., Werge, T., Ophoff, R. A., Rujescu, D., Børglum, A. D., Mors, O., Mortensen, P. B., Demontis, D., Hollegaard, M. V., van Winkel, R., Kenis, G., De Hert, M., Réthelyi, J. M., Bitter, I., Rubino, I. A., Golimbet, V., Kiemeney, L. A., van den Berg, L. H., Franke, B., Jönsson, E. G., Farmer, A., Stefansson, H., Stefansson, K., Collier, D. A., GROUP Consortium

    Biological Psychiatry, vol. 72, no. 8, pp. 645-650

    Contributions to Journals: Articles

  • Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis

    Derks, E. M., Vorstman, J. A., Ripke, S., Kahn, R. S., Ophoff, R. A., O'Donovan, M. C., Craddock, N., Holmans, P. A., Hamshere, M., Williams, H. J., Moskvina, V., Dwyer, S., Georgieva, L., Zammit, S., Owen, M. J., Sullivan, P. F., Lin, D. Y., van den Oord, E., Kim, Y., Scott Stroup, T., Lieberman, J. A., St Clair, D., Kirov, G. K., Nikolov, I., Toncheva, D., Milanova, V., Morris, D. W., O'Dushlaine, C. T., Kenny, E., Quinn, E. M., Gill, M., Corvin, A., Blackwood, D. H., McGhee, K. A., Pickard, B., Malloy, P., Maclean, A. W., McIntosh, A., McQuillin, A., Choudhury, K., Datta, S., Pimm, J., Thirumalai, S., Puri, V., Krasucki, R., Lawrence, J., Quested, D., Bass, N., Gurling, H., Pato, M. T., The Schizophrenia Psychiatric Genomic Consortium

    PloS ONE, vol. 7, no. 6, e37852

    Contributions to Journals: Articles

  • Runs of homozygosity implicate autozygosity as a schizophrenia risk factor

    Keller, M. C., Simonson, M. A., Ripke, S., Neale, B. M., Gejman, P. V., Howrigan, D. P., Lee, S. H., Lencz, T., Levinson, D. F., Sullivan, P. F., Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium, St Clair, D. M.

    PLoS Genetics, vol. 8, no. 4, e1002656

    Contributions to Journals: Articles

  • Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia

    Kim, J. Y., Liu, C. Y., Zhang, F., Duan, X., Wen, Z., Song, J., Feighery, E., Lu, B., Rujescu, D., St Clair, D., Christian, K., Callicott, J. H., Weinberger, D. R., Song, H., Ming, G.

    Cell, vol. 148, no. 5, pp. 1051-1064

    Contributions to Journals: Articles

  • A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia

    Jia, P., Wang, L., Fanous, A. H., Chen, X., Kendler, K. S., Zhao, Z., Morris, D. W., O'Dushlaine, C. T., Kenny, E., Quinn, E. M., Gill, M., Corvin, A., O'Donovan, M. C., Kirov, G. K., Craddock, N. J., Holmans, P. A., Williams, N. M., Georgieva, L., Nikolov, I., Norton, N., Williams, H., Toncheva, D., Milanova, V., Owen, M. J., Hultman, C. M., Lichtenstein, P., Thelander, E. F., Sullivan, P., McQuillin, A., Choudhury, K., Datta, S., Pimm, J., Thirumalai, S., Puri, V., Krasucki, R., Lawrence, J., Quested, D., Bass, N., Gurling, H., Crombie, C., Fraser, G., Kuan, S. L., Walker, N., St Clair, D., Blackwood, D. H., Muir, W. J., McGhee, K. A., Pickard, B., Malloy, P., Maclean, A. W., The International Schizophrenia Consortium (ISC)

    Journal of Medical Genetics, vol. 49, no. 2, pp. 96-103

    Contributions to Journals: Articles

  • Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

    Carrera, N., Arrojo, M., Sanjuán, J., Ramos-Ríos, R., Paz, E., Suárez-Rama, J. J., Páramo, M., Agra, S., Brenlla, J., Martínez, S., Rivero, O., Collier, D. A., Palotie, A., Cichon, S., Nöthen, M. M., Rietschel, M., Rujescu, D., Stefansson, H., Steinberg, S., Sigurdsson, E., St Clair, D., Tosato, S., Werge, T., Stefansson, K., González, J. C., Valero, J., Gutiérrez-Zotes, A., Labad, A., Martorell, L., Vilella, E., Carracedo, ., Costas, J.

    Biological Psychiatry, vol. 71, no. 2, pp. 169-177

    Contributions to Journals: Articles

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