Professor David St Clair

Professor David St Clair

Chair in Applied Medicine


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Research Overview

Psychiatric Genetics, particularly of schizophrenia.



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  • Common genetic variants on 1p13.2 associate with risk of autism

    Xia, K., Guo, H., Xun, G., Zuo, L., Peng, Y., He, Y., Xiong, Z., Sun, L., Pan, Q., Long, Z., Zou, X., Lu, L., Liu, Y., Tian, D., Long, L., Liu, Y., Peng, H., Luo, X., Su, W., Liang, D., Dai, H., Yan, X., Feng, Y., Tang, B., Miedzybrodzka, Z., Xia, J., Zhang, Z., Luo, X., Zhang, X., St Clair, D., Zhao, J., Zhang, F.

    Molecular Psychiatry, vol. 19, no. 11, pp. 1212-1219

    Contributions to Journals: Articles

  • Biological insights from 108 schizophrenia-associated genetic loci

    Ripke, S., Neale, B. M., Corvin, A., Walters, J. T., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C., Chen, R. Y., Chen, E. Y., Cheng, W., Cheung, E. F., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., St Clair, D., Schizophrenia Working Group of the Psychiatric Genomics Consortium

    Nature, vol. 511, no. 7510, pp. 421-427

    Contributions to Journals: Articles

  • Modeling a genetic risk for schizophrenia in iPSCs and Mice reveals neural stem cell deficits associated with adherens junctions and polarity

    Yoon, K. J., Nguyen, H. N., Ursini, G., Zhang, F., Kim, N. S., Wen, Z., Makri, G., Nauen, D., Shin, J. H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Hussaini, S. M. Q., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J. E., Hyde, T. M., Krauss, G., Christian, K. M., Rapoport, J. L., Weinberger, D. R., Song, H., Ming, G. L.

    Cell Stem Cell, vol. 15, no. 1, pp. 79-91

    Contributions to Journals: Articles

  • An inherited duplication at the gene p21 protein-activated Kinase 7 (PAK7) is a risk factor for psychosis

    Morris, D. W., Pearson, R. D., Cormican, P., Kenny, E. M., O'Dushlaine, C. T., Perreault, L. P. L., Giannoulatou, E., Tropea, D., Maher, B. S., Wormley, B., Kelleher, E., Fahey, C., Molinos, I., Bellini, S., Pirinen, M., Strange, A., Freeman, C., Thiselton, D. L., Elves, R. L., Regan, R., Ennis, S., Dinan, T. G., McDonald, C., Murphy, K. C., O'Callaghan, E., Waddington, J. L., Walsh, D., O'Donovan, M., Grozeva, D., Craddock, N., Stone, J., Scolnick, E., Purcell, S., Sklar, P., Coe, B., Eichler, E. E., Ophoff, R., Buizer, J., Szatkiewicz, J., Hultman, C., Sullivan, P., Gurling, H., Mcquillin, A., St Clair, D., Rees, E., Kirov, G., Walters, J., Blackwood, D., Johnstone, M., Donohoe, G., The International Schizophrenia Consortium (ISC), SGENE+ Consortium, O'Neill, F. A., The Wellcome Trust Case Control Consortium 2 (WTCCC2), Kendler, K. S., Gill, M., Riley, B. P., Spencer, C. C. A., Corvin, A.

    Human Molecular Genetics, vol. 23, no. 12, pp. 3316-3326

    Contributions to Journals: Articles

  • Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility

    Lang, B., Pu, J., Hunter, I., Liu, M., Martin-Granados, C., Reilly, T. J., Gao, G., Guan, Z., Li, W., Shi, Y., He, G., He, L., Stefansson, H., St Clair, D., Blackwood, D. H., McCaig, C. D., Shen, S.

    Journal of Cell Science, vol. 127, no. 3, pp. 630-640

    Contributions to Journals: Articles

  • A survey of rare coding variants in candidate genes in schizophrenia by deep sequencing

    Hu, X., Zhang, B., Liu, W., Paciga, S., He, W., Lanz, T. A., Kleiman, R., Dougherty, B., Hall, S. K., Mcintosh, A. M., Lawrie, S. M., Power, A., John, S. L., Blackwood, D., St Clair, D., Brandon, N. J.

    Molecular Psychiatry, vol. 19, no. 8, pp. 857-858

    Contributions to Journals: Letters

  • Can eye movements be used as a marker for major depression?

    Nouzova, E., Beedie, S. A., Bheemaraddi, S., Kuriakose, J., Kulkarni, M., Shand, A. J., Walker, N., St Clair, D., Benson, P. J.

    European Psychiatry, vol. 29, no. supplement 1, EPA-112

    Contributions to Journals: Abstracts

  • Mosaic copy number variation in schizophrenia

    Ruderfer, D. M., Chambert, K., Moran, J., Talkowski, M., Chen, E. S., Gigek, C., Gusella, J. F., Blackwood, D. H., Corvin, A., Gurling, H. M., Hultman, C. M., Kirov, G., Magnusson, P., O'Donovan, M. C., Owen, M. J., Pato, C., St Clair, D., Sullivan, P. F., Purcell, S. M., Sklar, P., Ernst, C.

    EJHG : European journal of human genetics : the official journal of the European Society of Human Genetics. , vol. 21, no. 9, pp. 1007-1011

    Contributions to Journals: Articles

  • A comprehensive family-based replication study of schizophrenia genes

    Aberg, K. A., Liu, Y., Bukszár, J., McClay, J. L., Khachane, A. N., Andreassen, O. A., Blackwood, D., Corvin, A., Djurovic, S., Gurling, H., Ophoff, R., Pato, C. N., Pato, M. T., Riley, B., Webb, T., Kendler, K., O'Donovan, M., Craddock, N., Kirov, G., Owen, M., Rujescu, D., St Clair, D., Werge, T., Hultman, C. M., Delisi, L. E., Sullivan, P., Van Den Oord, E. J.

    JAMA Psychiatry, vol. 70, no. 6, pp. 573-581

    Contributions to Journals: Articles

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