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Professor David St Clair

Professor David St Clair

Chair in Applied Medicine

Overview

Contact Details

Telephone
work +44 (0)1224 437965
work +44 (0)1224 557951
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Research

Research Overview

Psychiatric Genetics, particularly of schizophrenia.

Publications

Publications 

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  • Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function

    Thomson, P. A., Duff, B., Blackwood, D. H., Romaniuk, L., Watson, A., Whalley, H. C., Li, X., Dauvermann, M. R., Moorhead, T. W. J., Bois, C., Ryan, N. M., Redpath, H., Hall, L., Morris, S. W., Van Beek, E. J., Roberts, N., Porteous, D. J., St Clair, D., Whitcher, B., Dunlop, J., Brandon, N. J., Hughes, Z. A., Hall, J., McIntosh, A., Lawrie, S. M.

    npj Schizophrenia, vol. 2, 16024

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1038/npjschz.2016.24
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/11526/1/npjschz201624.pdf
    Additional Links
    View publication in Scopus

  • Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

    Singh, T., Kurki, M. I., Curtis, D., Purcell, S. M., Crooks, L., McRae, J., Suvisaari, J., Chheda, H., Blackwood, D., Breen, G., Pietilinen, O., Gerety, S. S., Ayub, M., Blyth, M., Cole, T., Collier, D., Coomber, E. L., Craddock, N., Daly, M. J., Danesh, J., DiForti, M., Foster, A., Freimer, N. B., Geschwind, D., Johnstone, M., Joss, S., Kirov, G., Körkkö, J., Kuismin, O., Holmans, P., Hultman, C. M., Iyegbe, C., Lönnqvist, J., Mnnikkö, M., McCarroll, S. A., McGuffin, P., McIntosh, A. M., McQuillin, A., Moilanen, J. S., Moore, C., Murray, R. M., Newbury-Ecob, R., Ouwehand, W., Paunio, T., Prigmore, E., Rees, E., Roberts, D., Sambrook, J., Sklar, P., St Clair, D., Veijola, J., Walters, J. T., Williams, H., Sullivan, P. F., Hurles, M. E., O'Donovan, M. C., Palotie, A., Owen, M. J., Barrett, J. C.

    Nature Neuroscience, vol. 19, no. 4, pp. 571-577

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1038/nn.4267
    Additional Links
    View publication in Scopus

  • Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

    Franke, B., Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., van Hulzen, K. J. E., Arias-Vasquez, A., Smoller, J. W., Nichols, T. E., Neale, M. C., McIntosh, A. M., Lee, P., McMahon, F. J., Meyer-Lindenberg, A., Mattheisen, M., Andreassen, O. A., Gruber, O., Sachdev, P. S., Roiz-Santianez, R., Saykin, A. J., Ehrlich, S., Mather, K. A., Turner, J. A., Wright, M. J., O'Donovan, M. C., Thompson, P. M., Neale, B. M., Medland, S. E., Sullivan, P. F., Psychiat Genomics Consortium, ENIGMA Consortium, St Clair, D. M., Pike, G. B.

    Nature Neuroscience, vol. 19, no. 3, pp. 420-431

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1038/nn.4228

  • Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia

    Ingason, A., Giegling, I., Hartmann, A. M., Genius, J., Konte, B., Friedl, M., Ripke, S., Sullivan, P. F., St Clair, D., Collier, D. A., O'Donovan, M. C., Mirnics, K., Rujescu, D.

    Translational Psychiatry, vol. 5, e656

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1038/tp.2015.151
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/11832/1/Expression_analysis_in_a_rat_psychosis_model_identifies_novel.pdf
    Additional Links
    View publication in Scopus

  • Bridging the translational divide: Identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

    Nithianantharajah, J., McKechanie, A. G., Stewart, T. J., Johnstone, M., Blackwood, D. H., St Clair, D., Grant, S. G., Bussey, T. J., Saksida, L. M.

    Scientific Reports, vol. 5, 14613

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1038/srep14613
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/11831/1/Bridging_the_translational_divide.pdf
    Additional Links
    View publication in Scopus

  • The UK10K project identifies rare variants in health and disease

    Walter, K., Min, J. L., Huang, J., Crooks, L., Memari, Y., McCarthy, S., Perry, J. R., Xu, C., Futema, M., Lawson, D., Iotchkova, V., Schiffels, S., Hendricks, A. E., Danecek, P., Li, R., Floyd, J., Wain, L. V., Barroso, I., Humphries, S. E., Hurles, M. E., Zeggini, E., Barrett, J. C., Plagnol, V., Richards, J. B., Greenwood, C. M., Timpson, N. J., Durbin, R., Bala, S., Clapham, P., Coates, G., Cox, T., Daly, A., Du, Y., Edkins, S., Ellis, P., Flicek, P., Guo, X., Guo, X., Huang, L., Jackson, D. K., Joyce, C., Keane, T., Kolb-Kokocinski, A., Langford, C., Li, Y., Liang, J., Lin, H., Liu, R., Breen, G., St Clair, D., UK10K Consortium

    Nature, vol. 526, no. 7571, pp. 82-89

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1038/nature14962
    Additional Links
    View publication in Scopus

  • Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness

    Johnstone, M., Maclean, A., Heyrman, L., Lenaerts, A., Nordin, A., Nilsson, L., De Rijk, P., Goossens, D., Adolfsson, R., St Clair, D. M., Hall, J., Lawrie, S. M., McIntosh, A. M., Del-Favero, J., Blackwood, D. H. R., Pickard, B. S.

    Journal of Neuropsychiatry and Clinical Neurosciences, vol. 1, no. 3, pp. 175-190

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1159/000438788
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/6052/1/438788.pdf

  • Prenatal Nutritional Deficiency Reprogrammed Postnatal Gene Expression in Mammal Brains: Implications for Schizophrenia

    Xu, J., He, G., Zhu, J., Zhou, X., Clair, D. S., Wang, T., Xiang, Y., Zhao, Q., Xing, Q., Liu, Y., Wang, L., Li, Q., He, L., Zhao, X.

    International Journal of Neuropsychopharmacology, vol. 18, no. 4, pyu054

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1093/ijnp/pyu054
    Additional Links
    View publication in Scopus

  • No Association Between NRG1 and ErbB4 Genes and Psychopathological Symptoms of Schizophrenia

    Tosato, S., Zanoni, M., Bonetto, C., Tozzi, F., Francks, C., Ira, E., Tomassi, S., Bertani, M., Rujescu, D., Giegling, I., St Clair, D., Tansella, M., Ruggeri, M., Muglia, P.

    NeuroMolecular Medicine, vol. 16, no. 4, pp. 742-751

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.1007/s12017-014-8323-9
    Additional Links
    View publication in Scopus
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