Professor Cosimo De Bari

Professor Cosimo De Bari
Professor Cosimo De Bari
Professor Cosimo De Bari

MD PhD FRCP, Hon Consultant Rheumatologist

Clinical Chair in Experimental Medicine and Rheumatology

About
Email Address
c.debari@abdn.ac.uk
Office Address

School of Medicine, Medical Sciences and Nutrition

University of Aberdeen

Aberdeen Centre for Arthritis and Musculoskeletal Health

Arthritis and Regenerative Medicine Laboratory

Institute of Medical Sciences

Foresterhill, Aberdeen AB25 2ZD

United Kingdom

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Professor Cosimo De Bari is a clinically active rheumatologist and a translational scientist with expertise in musculoskeletal regenerative medicine and arthritis pathophysiology. He has a long-standing interest and track record in the study of joint health and disease, with a focus on cell-based therapies for cartilage repair and osteoarthritis.

Cosimo graduated in Medicine (summa cum laude) from the University of Bari (Italy), where he underwent specialist training in Rheumatology. He obtained his PhD from the University of Leuven (Belgium). In 2003 Cosimo moved to King's College London, where in 2005 he was awarded an MRC Clinician Scientist Fellowship. Since 2007 Cosimo holds a clinical chair in Experimental Medicine and Rheumatology (previously Translational Medicine) at the University of Aberdeen.

Cosimo is the founder and director of the Aberdeen Centre for Arthritis and Musculoskeletal Health (awarded “Centre of Excellence in Rheumatology” status by the EULAR), leads the Arthritis and Regenerative Medicine Laboratory, and is deputy director of the Tissue Engineering & Regenerative Therapies Centre Versus Arthritis.

External Memberships

Cosimo has accepted more than 100 invitations to speak at national and international venues, including international conferences, and universities and institutes in Europe and overseas, or to chair sessions and symposia. He takes part in conference organising/program committees such as OARSI.

Cosimo is an Associate Editor for Osteoarthritis and Cartilage and a member of the editorial boards of several journals including Regenerative Medicine. He has served on numerous grant review panels of national and international funding agencies, including MRC, Versus Arthritis, NIHR, NC3R, Vienna Science and Technology Fund, Dutch Arthritis Foundation, California Institute for Regenerative Medicine, and European Commission.

Research

Research Overview

The ultimate goal of Professor De Bari's research programme is the development of novel cell-based therapeutic approaches to skeletal repair. His programme consists of two main areas.

The first is centred on the development and validation of "clinically relevant" assays and surrogate measures of the potency of stem cell preparations, to be used as quality controls for efficacy of stem cell therapies in the clinic.

The second area of investigation aims at characterizing the niches of resident stem cells within the joint environment and studying their molecular regulation in vivo in health and diseases such as osteoarthritis and rheumatoid arthritis. Understanding the roles of stem cells in the pathophysiology of joint homeostasis, remodelling and repair in health and disease will be instrumental for the development of novel therapeutic protocols to trigger and enhance intrinsic joint surface repair by targeting resident stem cells, with the ultimate goal to modify disease outcome and restore a functional joint homeostasis.

Publications

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  • Multipotent mesenchymal stem cells from adult human synovial membrane

    De Bari, C., Dell'Accio, F., Tylzanowski, P., Luyten, F. P.
    Arthritis & Rheumatism, vol. 44, no. 8, pp. 1928-1942
    Contributions to Journals: Articles
  • Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo

    Dell'Accio, F., De Bari, C., Luyten, F. P.
    Arthritis & Rheumatism, vol. 44, no. 7, pp. 1608-1619
    Contributions to Journals: Articles
  • Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age

    De Bari, C., Dell'Accio, F., Luyten, F. P.
    Arthritis & Rheumatism, vol. 44, no. 1, pp. 85-95
    Contributions to Journals: Articles
  • Interleukin-10 and interleukin-10 receptor in human osteoarthritic and healthy chondrocytes

    Iannone, F., De Bari, C., Dell'Accio, F., Covelli, M., Cantatore, F. P., Patella, V., Lo Bianco, G., Lapadula, G.
    Clinical and Experimental Rheumatology, vol. 19, no. 2, pp. 139-145
    Contributions to Journals: Articles
  • Coexisting psoriatic arthritis, gout, and chondrocalcinosis

    De Bari, C., Lapadula, G., Cantatore, F. P.
    Scandinavian Journal of Rheumatology, vol. 27, no. 4, pp. 306-309
    Contributions to Journals: Articles
  • Isolated thrombocytopenia associated with low dose methotrexate therapy

    Lapadula, G., De Bari, C., Acquista, C. A., Dell'Accio, F., Covelli, M., Iannone, F.
    Clinical Rheumatology, vol. 16, no. 4, pp. 429-430
    Contributions to Journals: Articles
  • Anti-bacterial antibodies in Behçet's disease

    Iannone, F., De Bari, C., Pipitone, V., Lapadula, G., Covelli, M.
    Clinical and Experimental Rheumatology, vol. 15, no. 4, pp. 451-452
    Contributions to Journals: Articles
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