Clinical and Translational studies in the musculoskeletal field at Aberdeen encompass a variety of research areas, many of which overlap due to the shared interests of researchers.
Regenerative medicine: Professor Cosimo De Bari is a clinically active rheumatologist with expertise in mesenchymal stem cell research for musculoskeletal repair and tissue engineering. He collaborates with Dr. Henning Wackerhage who is studying skeletal muscle stem cells (satellite cells) in relation to their regenerative potential.
Muscle physiology: Sarcopenia is loss of muscle mass and function that occurs during normal ageing. Dr Henning Wackerhage studies satellite cells, the major, resident stem cell of skeletal muscle. The expansion of satellite cells may have applications in targeting sarcopenia. Dr. Stuart Gray is also interested in sarcopenia and how this can have major effects on physical function and quality of life in the elderly. He is investigating ways in which the anabolic resistance to exercise and food intake which is exhibited by elderly muscles could be overcome. Dr. Arimantas Lionikas is interested in the genetic mechanisms underlying variation in muscle function and in muscle-tendon-bone organization. Dr. Aivaras Ratkevicius is working on metabolic control and obesity.
Bone health and lifestyle factors: Professor Helen Macdonald studies the effects of nutrition on bone health, specifically the role of fruit and vegetables, vitamin D, whole diet patterns and timing in relation to bone health and other chronic conditions. Dr. Alexandra Mavroeidi has research interests in lifestyle factors (mainly physical activity and diet) and genetic factors influencing musculoskeletal diseases, and in gene-physical activity interactions affecting bone health. Dr. Rebecca Barr studies factors associated with falls and balance that can lead to increased fracture risk.
Imaging and bone disease: Dr. Jenny Gregory’s main research interests lie in medical image processing and analysis, focusing on the shape of the femur and the trabecular structure on radiographs and DXA scans and seeing how they relate to bone disorders such as osteoporosis and osteoarthritis.