Chemotherapy-induced neuropathic pain is a challenging clinical problem, affecting up to a third of patients. Emerging evidence from chemotherapy-induced neuropathy models indicates that mitochondrial dysfunction as a result of oxidative stress may play a key role. We have shown that in dorsal root ganglion cells in vitro chemotherapy-induced mitochondrial damage can be prevented by antioxidants which protect mitochondria. The efficacy of mitochondrial targeted antioxidants on objective behavioural measures of neuropathic pain and neurobiological changes in the spinal cord and the role of transient receptor potential vanilloid receptors are under investigation in collaboration with colleagues at the University of Edinburgh.
- Barry McCormick
- Professor Helen Galley