MelatoninMarked oxidative stress as a result of the inflammatory responses inherent with sepsis initiates changes in mitochondrial function which may result in organ damage. Antioxidants which accumulate within mitochondria protect against oxidative stress-induced damage better than non-targeted antioxidants in several disease models. Melatonin is a profound antioxidant which accumulates inside mitochondria and laboratory studies have shown that it reduces inflammatory responses and organ dysfunction as a result of sepsis. We are now investigating the potential of melatonin as a therapy for sepsis.