Neuronal Disease

Astrocytes in the damaged spinal cord (Mey and McCaffery)Every behaviour, action or decision we take in the world is governed by our nervous system and diseases of the nervous system break down our ability to function.  Sadly such disorders are all too common; damage to the spinal cord will paralyze limbs, motor neuron disease or Parkinson’s disease disable movement while diabetic neuropathy will lead to loss of peripheral nerves with many damaging consequences.  More pernicious are the diseases that effect thought and cognition, destroying the ability to reason.  Alzheimers disease will spiral into complete dementia, depression will degrade the pleasure of life, schizophrenia fracture coherent thought.

Researchers in Aberdeen neuroscience are tackling all these diseases through the discovery of the genes and proteins that underlie these disorders and understanding how malfunctions in these molecules can lead to disease.  Many researchers are taking a translational or “bench to bedside” approach, working with clinicians to take molecular discoveries towards the development of cure for disease.

The Aging Brain

The Aging Brain

A SPECT scan of blood flow (A) and positron emission tomorgraphy (B) in Alzheimer’s disease and a T2 axial MRI scan of a normal brain (C) (Murray)

A successful line of research by Aberdeen scientists has been the study of the aging brain; not a disease but a process of inevitable deterioration that we all must bear.  A combination of brain imaging, genetic, molecular and pathological studies aim to provide a complete neurobiological description of the events that lead to the progressive failure of the brain with age.  These studies will show how this decline may be slowed.

People

Neuronal Disease

The Aging Brain

Guy Bewick

Alberto Di Salvo

Stuart Cruickshank

Susan J. Duthie

Wenlong Huang

Gareth Jones

Bing Lang

Julie Jones

Gary Macfarlane

Mary Joan MacLeod

Alasdair MacKenzie

Alison Murray

Colin McCaig

Louise Phillips

Peter McCaffery

Bettina Platt

Alison Murray

Professor Gernot Reidel

Bettina Platt

Gordon Waiter

Professor Gernot Reidel

 

Derryck Shewan

 

Professor David St Clair