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The University of Aberdeen
Office: G11 Aberdeen Biomedical Imaging Centre Lilian Sutton Building Foresterhill Aberdeen AB25 2ZD United Kingdom
Vesna Vuksanovic joined University of Aberdeen as Research Fellow in Neuroimaging. She was appointed Research Fellow at Technical University of Berlin Institute of Theoretical Physics and at Bernstein Centre for Computational Neuroscience Berlin. She has been a Royal Society Visiting Research Fellow at Lancaster University Department of Physics.
In my work I combine methods and concepts from physics (e.g., complex systems) and statistical methods of graph theory and apply them to fundamental problems in clinical and cognitive neuroscience. Complex systems methods provide a framework for analysing increasingly complex, multimodal, big-datasets in neuroimaging and represent emerging clinical tools for assessing brain-network disorders. I am using these methods to understand how different brain areas interact with each other to support normal cognitive functions and how brain diseases, such as neurodegenerative diseases that cause dementias, impact these interactions. My aim is to develop a model of the brain that maps neurodegeneration in dementia in a way that helps clinicians when diagnosing patients and when selecting those who would benefit from currently available treatments for dementia or from participating in clinical trials.
clinical trials of novel Tau Aggregation Inhibitor therapies in Alzheimer's disease
behavioural variant FrontoTemporal Dementia
Current work combines neuroimaging and clinical data in patients with Alzheimer’s disease and behavioural variant frontotemporal dementia. Alzheimer’s disease and behavioural variant frontotemporal dementia are two brain diseases that can cause dementia. Both diseases cause progressive loss of cognitive abilities and behavioural problems to greater or less extent. There are no current treatments for either disease that stops or reverses disease progression. Both diseases can cause similar symptoms and it is difficult to diagnose either condition or to distinguish them, especially in their early stages when new treatments are likely to be most valuable. Using information about patterns of loss of brain tissue across different parts of the brain, I am developing new ways of assessing brain scans and test results so that these methods give us a more accurate maps of the brain in these patients and give us new ways of making diagnosis. The research is supported by the WisTa LAboratories Ltd futured TAURx.
Reference: IJNS (in-press)This study represents first attempt to characterize the correlational networks in cortical thickness and surface area in a large population of behavioural variant FrontoTemporal Dementia and Alzheimer's disease. These networks were bulit on (anatomical) T1 MRI scans used in routine clinical practice.
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
Schelter, B. O., Shiells, H. C., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
Organisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes
Vuksanovic, V., Staff, R., Ahearn, T., Bentham, P., Murray, A. D., Wischik, C. M.
6th Cambridge Neuroscience Symposium
Contributions to Conferences: Abstracts
Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial
Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457