Dr Jiabao He
Institute of Medical Sciences,
School of Medicine, Medical Sciences and Nutrition,
Aberdeen, AB25 2ZD
Dr Jiabao He is a magnetic resonance (MR) physicist with a strong focus on the enhancement and application of advanced MR methodologies for clinical purposes. He is developing the Cancer Imaging Group (CIG), with a focus on women's health.
Jiabao received a BSc in physics from Fudan University, Shanghai, China in 1999, after completing a four year degree within three years. He subsequently conducted his PhD study with Prof Peter Morris (CBE) at the Sir Peter Mansfield MR Centre in Nottingham on the combination of functional MR imaging (fMRI) and magnetoencephalography (MEG). Despite serious health issues resulting in the loss of a significant portion of eyesight, he completed his PhD successfully. He moved to Sheffield in 2003 to work as a postdoctoral research associate with Dr Nikos Papadakis and Prof John Mayhew to develop a novel fMRI modality based on neuronal cell swelling in the preclinical environment. During this time, he gained extensive expertise in sequence programming, arterial spin labelling (ASL) for cerebral perfusion measurement and advanced diffusion MRI methods. In 2006, he moved to Newcastle MR Centre to work as a postdoctoral research fellow with Prof Andrew Blamire. He developed ASL, 3D chemical shift imaging (CSI) and multiparametric MRI in conjunction with Valsalva manoeuvre, as well as applying these techniques in hypertension, traumatic brain injury (TBI), stroke, chronic fatigue syndrome (CFS), dementia and depression patients and healthy ageing populations. In 2013, Jiabao took the lectureship position offered by the University of Aberdeen.
The long-term mission of Jiabao’s group is to relieve human suffering through rapid translation of advanced methodologies into clinical care.
Member of International Society of Magnetic Resonance in Medicine (ISMRM)
Member of British Chapter of ISMRM (BCISMRM)
Jiabao's research interests focus on the development and application of advanced magnetic resonance methods in clinical research. The emphasis is on quantitative and novel contrast techniques revealing essential physiological parameters, with a clear potential in clinical applications.
The research programme has three core areas: (1) vascular function, (2) tissue microstructure and (3) metabolic function.
- Vascular function. Jiabao has a long standing track record in the development and application of MR perfusion methodologies in a range of research settings. The flagship methodology of arterial spin labelling (ASL) is a high precision MR technique for the measurement of cerebral blood flow (CBF). The fact that the signal level of ASL is only about 1-2% of conventional imaging signal, imposes a demand of high level of expertise and experience.
- Tissue microstructure. Similar to ASL, diffusion MRI is one of the most advanced branches in MRI, with established methods in diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI). However, these methods only provide an indicator of microstructure rather than absolute quantification. Jiabao has applied these methods in clinical population, as well as investigating more advanced tools such as q-space imaging for direct tissue microstructure quantification.
- Metabolic function. Magnetic Resonance Spectroscopy (MRS) is a valuable tool in assessing tissue chemical composition and metabolic function. Chemical Shift Imaging (CSI) is a three dimensional version of MRS, allowing spatially resolved chemical detection. Jiabao has experience in 1H and 31P MRS and CSI.
The aim of the methodology development program is to integrate vascular function, tissue microstructure and metabolic function techniques to reveal physiology and pathophysiology via a system medicine approach.
Jiabao's current research focuses on breast cancer imaging to support the area of research excellence of women’s health in Aberdeen. The research programme is underpinned by highly sought after specialist MR methodology only deliverable by handful of centres worldwide. In this sense, the philosophy, governing investment planning, is to focus on a small number of areas to the level of world class standard.
This research programme is supported by harmonisation between flexibility in methodology innovation and rigidity in clinical studies. The Cancer Imaging Group (CIG) has already demonstrated the ability of identifying critical clinical questions, developing novel MR methodologies, source research funding, organising clinical trials and publication of research findings.
We regularly support the educational programme at the Breast Unit of Aberdeen Royal Infirmary, and public events hosted by our local charity partner Friends of ANCHOR. We have strong working relationship with our industrial partner Philips Healthcare, and regularly provide expert feedback on products and services.
The Cancer Imaging Group (CIG) takes great pride in quality standards and guarantees the data quality produced by the group. The CIG operates on a merit based system, with a culture of openness, fairness and respect of private ownership. The group is constantly seeking collaborators with a long term research focus and mission.
- Prof David Lurie (Head of Fast Field Cycling Laboratory, University of Aberdeen)
- Prof Andrew Blamire (Director of Centre for In Vivo Imaging/Dean of Research, Newcastle University)
- Dr Matthew Clemence (Senior Clinical Scientist, Philips Healthcare)
- Dr Bernard Siow (Head of MR Facility, Francis Crick Institute)
- Dr Andrew Starkey (Computer Scientist, University of Aberdeen)
- Prof Steve Heys (Consultant Breast Surgeon, Aberdeen Royal Infirmary)
- Prof Zosia Miedzybrodzka (Professor in medical Genetics, University of Aberdeen)
- Prof Valerie Speirs (Chair in Molecular Medicine, University of Aberdeen)
- Dr Yazan Masannat (Consultant Breast Surgeon, Aberdeen Royal Infirmary)
- Dr Ehab Husain (Consultant Pathologist, Aberdeen Royal Infirmary)
- Dr Tanja Gagliardi (Consultant Radiologist, Royal Marsden)
- Dr Ravi Sharma (Consultant Oncologist, Aberdeen Royal Infirmary)
- Dr Trevor McGoldrick (Consultant Oncologist, Aberdeen Royal Infirmary)
Chronic disease portfolio
- Dr Neil Basu (Reumatologist, University of Glasgow)
- Dr Stuart Gray (Sports Scientist, University of Glasgow)
- Prof Julia Newton (Consultant Old Age Specialist, Newcastle University)
- Prof John O’Brien (Consultant Old Age Psychiatrist, Cambridge University)
- Prof Gary Ford (CBE, Consultant Cardiologist, Oxford University)
- Prof Hugh Marques (Consultant Stroke Specialist, Cambridge University)
Jiabao currently is the primary supervisor of one Post-Doctoral Research Fellow and one PhD student. In the past 3 years, we have 3 PhD students successfully completing their PhD, each achieving multiple journal publications. In addition, we have supervised 7 MSc students for their research projects, with 5 receiving distinction and 2 receiving commodation.
We are privileged to work with these energetic young scientists, with a common mission to make real difference to the progression of the human race. The high requirement imposed by a methodology group operating in clinical domain is a perfect foundry for future scientific leader. We are also grateful to the funders, including BBSRC, Cancer Research UK, Commonwealth Scholarship Commission, Tenovus Scotland, Roland Sutton Academic Trust, Elphinstone scholarship for financially supporting these endeavours.
We are seeking highly motivated and ambitious individuals to join us. We particularly value personal qualities of self determination and self reliance.
Gabriel Cheung, Post-doctoral Research Felow
Kangwa Nkonde, first year PhD student
Nicholas Senn, independent researcher (Former PhD student)
Kwok-Shing Chan, independent researcher (Former MSc student)
Vasiliki Mallikourti, independent researcher (Former PhD student)
Funding and Grants
Principal Investigator Grants*
 2021, Friends of ANCHOR. J. He, Z. Miedzybrodzka, Y. Masannat, S. M. Cheung. £13,860
 2021, Commonwealth Scholarship Commission. J. He. £78,120
 2020, Scottish Funding Council. J. He, Z. Miedzybrodzka, Y. Masannat. £35,764
 2019, Cancer Research UK. J. He, Z. Miedzybrodzka, Y. Masannat, T. Gagliardi. £72,085
 2018, NHS Grampian Endowments. J. He, T. Gagliardi, Y. Masannat, E. Husain, R. Sharma. £11,936
 2018, Roland Sutton Academic Trust. J. He. £8,409
 2017, Friends of ANCHOR. J. He, T. Gagliardi, R. Sharma, Y. Masannat, E. Husain. £9,744
 2017, NHS Grampian Endowments. J. He, T. Gagliardi, R. Sharma, E. Husain, Y. Masannat. £11,501
 2017, Tenovus Scotland. J. He, T. Gagliardi, R. Sharma, E. Husain, Y. Masannat. £12,064
 2016, Friends of ANCHOR. J. He, K. Wahle, Y. Masannat, E. Husain. £9,604
 2016, Princess Royal Tenovus Scotland Medical Research Scotland. J. He, K. Wahle, Y. Masannat, E. Husain. £80,000
 2016, Roland Sutton Academic Trust. J. He. £29,203
 2015, NHS Grampian Endowments. J. He, S. D. Heys, E. Husain, B. Siow. £11,802
 2015, Friends of ANCHOR. J. He, S. D. Heys, E. Husain. £8,920
 2015, BBSRC EastBio. J. He. £80,000
 2015, Roland Sutton Academic Trust. J. He. £7,863
 2015, NHS Grampian Endowments. D. Dawson, J. He, T. Ahearn. £10,440
 2015, LUPUS UK. N. Basu, L. P. Erwig, J. He, G. D. Waiter, S. R. Gray. £35,052
 2014, NHS Grampian Endowments. P. Myint, S. R. Gray and J. He. £11,936
MBChB Year 4 Student Selected Component (SSC) course coordinator
- Transition from exam driven learning to self motivated career focused learning
- Development of leadership quality, team work and workplace skills
- Development of critical thinking and the ability of giving and receiving critique
MSc in Biomedical Physics, MRI deep study
- Lecture 1: Image Contrast and Sequence Parameters
- Lecture 2: Flow Imaging and MR Angiography
- Research Project Supervision
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Peri-tumoural spatial distribution of lipid composition and tubule formation in breast cancerBMC Cancer, vol. 22, 285Contributions to Journals: Articles
Intra-tumoural lipid composition and lymphovascular invasion in breast cancer via non-invasive magnetic resonance spectroscopyEuropean Radiology, vol. 31, pp. 3703–3711Contributions to Journals: Articles
Phased-array combination of 2D MRS for lipid composition quantification in patients with breast cancerScientific Reports, vol. 10, 20041Contributions to Journals: Articles
Lactate concentration in breast cancer using advanced magnetic resonance spectroscopyBritish Journal of Cancer, vol. 123, no. 2, pp. 261-267Contributions to Journals: Articles
Metabolic and structural skeletal muscle health in systemic lupus erythematosus related fatigue: a multi-modal magnetic resonance imaging studyArthritis Care & Research, vol. 71, no. 12, pp. 1640-1646Contributions to Journals: Articles
q-Space Imaging Yields a Higher Effect Gradient to Assess Cellularity than Conventional Diffusion-weighted Imaging Methods at 3.0 T: A Pilot Study with Freshly Excised Whole-Breast TumorsRadiology: Imaging Cancer, vol. 1, no. 1, e190008Contributions to Journals: Articles
Optimal Phased-Array Signal Combination For Polyunsaturated Fatty Acids Measurement In Breast Cancer Using Multiple Quantum Coherence MR Spectroscopy At 3TScientific Reports, vol. 9, 9529Contributions to Journals: Articles
Grey and white matter differences in Chronic Fatigue Syndrome: A voxel-based morphometry studyNeuroImage: Clinical, vol. 17, pp. 24-30Contributions to Journals: Articles
Intracranial compliance is associated with symptoms of orthostatic intolerance in chronic fatigue syndromePloS ONE, vol. 13, no. 7, 0200068Contributions to Journals: Articles
Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodiesTranslational Psychiatry, vol. 6, pp. 1-8Contributions to Journals: Articles