Professor Simon Parson

Professor Simon Parson
FAS

Regius Chair of Anatomy

Overview
Professor Simon Parson
Professor Simon Parson

Contact Details

Telephone
work +44 (0)1224 274328
Email
Address
The University of Aberdeen Anatomy Rm 324 Suttie Centre Foresterhill University of Aberdeen Aberdeen AB24 3HF

Biography

BSc Zoology, University of Durham, 1987 

PhD Neuroscience, University of Edinburgh, 1990

Lecturer in Anatomy, University of Leeds, 1995

Senior Lecturer in Anatomy, University of Edinburgh, 2006

Professor of Anatomy, University of Aberdeen, 2013

Regius Chair of Anatomy, 2018

Research

Research Interests

Spinal Muscular Atrophy

Systemic involvement in neurodegeneration, espciall the cardiovascular system

Effects of Hypoxia and ischanemia on the nervous system

Current Research

Spinal muscular Atrophy (SMA) is a childhood form of Motor Neurone Disease. It is caused by a defect in a gene which 1:35 of us carry. When two carriers come together there is a 1:4 chance of producing an affected child. SMA is the second most common genetic cause of infant death, affecting between 1:6-10,000 live births Worldwide. The most severely affected children will never sit unaided and will die before their second birthday. The disease is characterised by a loss of motor neurones and resultant muscle weakness and inability to carry out co-ordinated motor tasks including breathing. The genetic defect is well-characterised and attempts to replace or reduce the severe depletion of the key Survival of Motor Neurone (SMN) protein are ongoing. However, even when protein levels in motor neurones are increased and improvements in motor parameters are reported, survival is not increased. 

There is an increasing appreciation that this is not a classical motor neurone disease, but rather a systemic disease in which motor neurones are either most vulnerable or that defects in them are most clinically relevant. 

Our research has pionered significant pre and early symptomatic defects in the cardiovascular system, where the heart, blood vessels and circulating cells are all defective in SMA. We are now particulary interested to determine how this impacts on SMA disease development and progression. This is particularly relevant in the new post-Nusinersen/ Spinraza treatment landscape, as this soleley targets neuronal defects.

We are currenty exploring the extent to which the non-neuronal pathologies described in animal models are also seen in human post-mortem material and are using cellular models to determine the vulnerabilities of SMA cells to hypoxic environments. These will help us to understand and develop novel combinatorial therapies to treat the entirity of SMA pathology in patients. 

Collaborations

Professor Tom Gillingwater: University of Edinburgh

Dr Tom Wishart: Roslin Institute Edinburgh

Dr Lyndsay Murray: University of Edinburgh

Dr's Francesco Muntoni and Haiyan Zhou: UCL, London

Prof Rashmi Kothary: University of Ottawa, Canada

Prof Charlotte Sumner: John Hopkins University, USA

Research Grants

SMA Europe 

Anatomical Society 

Tenovus Scotland

Teaching

Teaching Responsibilities

All aspects of Anatomy teaching to Medical and Science students

Further Info

External Responsibilities

Elected Councillor, Anatomical Society: 2010-2016

Meetings Officer, Anatomical Society: 2011- 2016

IFAA Programme Secretary: 2018 -

Admin Responsibilities

All aspects relating to Home Office legislation of anatomical teaching and research

College Teaching and Learning Committee

Division of Medical and Dental Education Executive Committee

Year 1-3 Medical Executive Committees

Medicine Curriculum Steering Group

Publications

Publications 

Currently viewing:

Page 1 of 1 Results 1 to 56 of 56

  • Robinson, H, Mishra, S, Davies, L, Craigen, F, Vilcina, V, Parson, S & Shahana, S 2020, 'An anatomical evaluation of a conventional Pectoralis II versus a Sub-Serratus plane block for breast surgery', Anesthesia and Analgesia.
  • Brassett, C, Cosker, T, Davies, DC, Dockery, P, Gillingwater, TH, Lee, TC, Milz, S, Parson, SH, Quondamatteo, F & Wilkinson, T 2020, 'COVID-19 and Anatomy: Stimulus and Initial Response', Journal of Anatomy. [Online] DOI: https://doi.org/10.1111/joa.13274
  • Bisset, CN, Dames, N, Oliphant, R, Alasadi, A, Anderson , D, Parson, S, Cleland, J & Moug, SJ 2020, 'Exploring shared surgical decision-making from the patient’s perspective: is the personality of the surgeon important?', Colorectal Disease. [Online] DOI: https://doi.org/10.1111/codi.15237
  • Allardyce, H, Kuhn, D, Hernandez Gerez, E, Hensel, N, Huang, YT, Faller, K, Gillingwater, TH, Quondamatteo, F, Claus, P & Parson, SH 2020, 'Renal pathology in a mouse model of severe Spinal Muscular Atrophy is associated with downregulation of Glial Cell-Line Derived Neurotrophic Factor (GDNF)', Human Molecular Genetics. [Online] DOI: https://doi.org/10.1093/hmg/ddaa126
  • Hernandez Gerez, E, Dall'angelo, S, Collinson, J, Parson, S & Fleming, I 2020, 'Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA', Annals of Clinical and Translational Neurology.
  • Hernandez Gerez, E, Fleming, IN & Parson, SH 2019, 'A role for spinal cord hypoxia in neurodegeneration', Cell Death & Disease, vol. 10, 861. [Online] DOI: https://doi.org/10.1038/s41419-019-2104-1
  • Deguise, MO, Baranello, G, Mastella, C, Beauvais , A, Michaud, J, Leone, A, De Amicis, R, Battezzati, A, Dunham, C, Selby, K, Chardon, JW, McMillan, HJ, Huang, YT, Courtney, NL, Mole, AJ, Kubinski, S, Claus, P, Murray, LM, Bowerman, M, Gillingwater, TH, Bertoli, S, Parson, SH & Kothary, R 2019, 'Abnormal fatty acid metabolism is a core component of spinal muscular atrophy', Annals of Clinical and Translational Neurology, vol. 6, no. 8, pp. 1519-1532. [Online] DOI: https://doi.org/10.1002/acn3.50855
  • Šoltić, D, Shorrock, HK, Allardyce, H, Wilson, EL, Holt, I, Synowsky, SA, Shirran, SL, Parson, SH, Gillingwater, TH & Fuller, HR 2019, 'Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy', Human Molecular Genetics, vol. 28, no. 21, pp. 3515–3527. [Online] DOI: https://doi.org/10.1093/hmg/ddz195
  • Chouari, TAM, Lindsay, K, Bradshaw, E, Parson, S, Watson, L, Ahmed, J & Curnier, A 2018, 'An enhanced fresh cadaveric model for reconstructive microsurgery training', European Journal of Plastic Surgery, vol. 41, no. 4, pp. 439-446. [Online] DOI: https://doi.org/10.1007/s00238-018-1414-3
  • Maxwell, GK, Szunyogova, E, Shorrock, HK, Gillingwater, TH & Parson, SH 2018, 'Developmental and Degenerative Cardiac Defects in the Taiwanese Mouse Model of Severe Spinal Muscular Atrophy', Journal of Anatomy, vol. 232, no. 6, pp. 965-978. [Online] DOI: https://doi.org/10.1111/joa.12793
  • Fergusson, SJ, Aka, JJ, Hennessy, CM, Wilson, AJ, Parson, SH, Harrison, EM, Finn, GM & Gillingwater, TH 2018, 'Examining the impact of audience response systems on student performance in anatomy education: a randomized controlled trial', Scottish Medical Journal, vol. 63, no. 1, pp. 16-21. [Online] DOI: https://doi.org/10.1177/0036933017741409
  • Robinson, H, Mishra, S, Nestor, C, Cragen, F, Davies, L, Parson, SH & Shahana, S 2018, 'Is the Conventional Ultrasound Guided Pectoralis II or Sub-serratus Plane Superior for Brest Surgery: A Cadaveric Study', Europian Society of Regional Anesthesia, Congress (ESRA 2018), Dublin, Ireland, 12/09/18 - 15/09/18. <> [Online] DOI: https://www.morressier.com/article/5--conventional-ultrasound-guided-pectoralis-ii-subserratus-plane-superior-breast-surgery-cadaveric-study/5b519f6ab1b87b000ecf17fc
  • Robinson, H, Mishra, S, Nestor, C, Cragen, F, Davies, L, Parson, SH & Shahana, S 2018, 'Is the Conventional Ultrasound Guided Pectoralis II or Sub-serratus Plane Superior for Brest Surgery: A Cadaveric Study', Regional Anesthesia and Pain Medicine, vol. 43, no. Suppl 1. <> [Online] DOI: https://rapm.bmj.com/content/43/Suppl_1
  • Robinson, H, Mishra, S, Nestor, C, Cragen, F, Davies, L, Parson, SH & Shahana, S 2018, 'Is the Conventional Ultrasound Guided Pectoralis II or Sub-serratus Plane Superior for Brest Surgery: A Cadaveric Study', Europian Society of Regional Anesthesia, Congress (ESRA 2018), Dublin, Ireland, 12/09/18 - 15/09/18. <> [Online] DOI: https://www.morressier.com/article/5--conventional-ultrasound-guided-pectoralis-ii-subserratus-plane-superior-breast-surgery-cadaveric-study/5b519f6ab1b87b000ecf17fc
  • Thomson, AK, Somers, E, Powis, RA, Shorrock, HK, Murphy, K, Swoboda, KJ, Gillingwater, TH & Parson, SH 2017, 'Survival of motor neurone protein is required for normal postnatal development of the spleen', Journal of Anatomy, vol. 230, no. 2, pp. 337–346 . [Online] DOI: https://doi.org/10.1111/joa.12546
  • Ezzat, A, Dynes, K & Parson, SH 2016, 'Evolving student–faculty partnerships in medical education through peer-assisted learning', Medical Education, vol. 50, no. 5, pp. 568-568. [Online] DOI: https://doi.org/10.1111/medu.13015
  • Scoto, M, Zhou, H, Thompson, D, Howell, K, Hong, Y, Imbrigiotta, N, Parson, S, Brogan, P & Muntoni, F 2016, 'Exploring the microvascular abnormalities in a cohort of paediatric patients with spinal muscular atrophy: P.51', Neuromuscular Disorders, vol. 26, no. Suppl. 2, pp. S105. [Online] DOI: https://doi.org/10.1016/j.nmd.2016.06.073
  • Szunyogova, E & Parson, SH 2016, 'Histological and Histochemical Methods, Theory and Practice, 5th Ed', Journal of Anatomy, vol. 228, no. 5, pp. 887. [Online] DOI: https://doi.org/10.1111/joa.12390
  • Sintusek, P, Catapano, F, Angkathunkayul, N, Marrosu, E, Parson, SH, Morgan, JE, Muntoni, F & Zhou, H 2016, 'Histopathological Defects in Intestine in Severe Spinal Muscular Atrophy Mice Are Improved by Systemic Antisense Oligonucleotide Treatment', PloS ONE, vol. 11, no. 5, 0155032, pp. 1-15. [Online] DOI: https://doi.org/10.1371/journal.pone.0155032
  • Szunyogova, E, Zhou, H, Maxwell, GK, Powis, RA, Muntoni, F, Gillingwater, TH & Parson, SH 2016, 'Survival Motor Neuron (SMN) protein is required for normal mouse liver development', Scientific Reports, vol. 6, 34635, pp. 1-14. [Online] DOI: https://doi.org/10.1038/srep34635
  • Powis, RA, Karyka, E, Boyd, P, Come, J, Jones, RA, Zheng, Y, Szunyogova, E, Groen, EJN, Hunter, G, Thomson, D, Wishart, TM, Becker, CG, Parson, SH, Martinat, C, Azzouz, M & Gillingwater, TH 2016, 'Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy', JCI Insight, vol. 1, no. 11, e87908, pp. 1-16. [Online] DOI: https://doi.org/10.1172/jci.insight.87908
  • Somers, E, Lees, RD, Hoban, K, Sleigh, JN, Zhou, H, Muntoni, F, Talbot, K, Gillingwater, TH & Parson, SH 2016, 'Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy', Annals of Neurology, vol. 79, no. 2, pp. 217-230. [Online] DOI: https://doi.org/10.1002/ana.24549
  • Parson, S, Ezzat, M, Foster, O, Moffat, M & Johnston, P 2015, 'An Investigation Into Student Perceptions of Peer Learning During a Medical Undergraduate Course', The FASEB Journal, vol. 29, no. Suppl. 1.
  • Kinsella, A, Parson, S & Davidson, DM 2015, 'An anatomical study of the neurovascular anatomy of the web spaces between the fingers', Journal of hand surgery-European volume, vol. 40, no. 7, pp. 755-757. [Online] DOI: https://doi.org/10.1177/1753193414534382
  • Zhou, H, Ying, H, Scoto, M, Brogan, P, Parson, S & Muntoni, F 2015, 'Microvascular abnormality in spinal muscular atrophy and its response to antisense oligonucleotide therapy', Neuromuscular Disorders, vol. 25, no. Suppl. 2, pp. S193. [Online] DOI: https://doi.org/10.1016/j.nmd.2015.06.038
  • Wishart, TM, Mutsaers, CA, Riessland, M, Reimer, MM, Hunter, G, Hannam, ML, Eaton, SL, Fuller, HR, Roche, SL, Somers, E, Morse, R, Young, PJ, Lamont, DJ, Hammerschmidt, M, Joshi, A, Hohenstein, P, Morris, GE, Parson, SH, Skehel, PA, Becker, T, Robinson, IM, Becker, CG, Wirth, B & Gillingwater, TH 2014, 'Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy', The Journal of Clinical Investigation, vol. 124, no. 4, pp. 1821-1834. [Online] DOI: https://doi.org/10.1172/JCI71318
  • Parson, SH 2014, 'The singular qualities of motor neurones in health and disease', Journal of Anatomy, vol. 224, no. 1, pp. 1-2. [Online] DOI: https://doi.org/10.1111/joa.12110
  • Good, DW, Khan, A, Hammer, S, Scanlan, P, Shu, W, Phipps, S, Parson, SH, Stewart, GD, Reuben, R & McNeill, SA 2014, 'Tissue quality assessment using a novel direct elasticity assessment device (the E-finger): a cadaveric study of prostatectomy dissection', PloS ONE, vol. 9, no. 11, e112872. [Online] DOI: https://doi.org/10.1371/journal.pone.0112872
  • Somers, E, Riessland, M, Schreml, J, Wirth, B, Gillingwater, TH & Parson, SH 2013, 'Increasing SMN levels using the histone deacetylase inhibitor SAHA ameliorates defects in skeletal muscle microvasculature in a mouse model of severe spinal muscular atrophy', Neuroscience Letters, vol. 544, pp. 100-104. [Online] DOI: https://doi.org/10.1016/j.neulet.2013.03.052
  • Schreml, J, Riessland, M, Paterno, M, Garbes, L, Roßbach, K, Ackermann, B, Krämer, J, Somers, E, Parson, SH, Heller, R, Berkessel, A, Sterner-Kock, A & Wirth, B 2013, 'Severe SMA mice show organ impairment that cannot be rescued by therapy with the HDACi JNJ-26481585', EJHG : European journal of human genetics : the official journal of the European Society of Human Genetics. , vol. 21, no. 6, pp. 643-652. [Online] DOI: https://doi.org/10.1038/ejhg.2012.222
  • Somers, E, Stencel, Z, Wishart, TM, Gillingwater, TH & Parson, SH 2012, 'Density, calibre and ramification of muscle capillaries are altered in a mouse model of severe spinal muscular atrophy', Neuromuscular Disorders, vol. 22, no. 5, pp. 435-442. [Online] DOI: https://doi.org/10.1016/j.nmd.2011.10.021
  • Findlater, GS, Kristmundsdottir, F, Parson, SH & Gillingwater, TH 2012, 'Development of a supported self-directed learning approach for anatomy education', Anatomical Sciences Education, vol. 5, no. 2, pp. 114-121. [Online] DOI: https://doi.org/10.1002/ase.1255
  • Thomson, SR, Nahon, JE, Mutsaers, CA, Thomson, D, Hamilton, G, Parson, SH & Gillingwater, TH 2012, 'Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy', PloS ONE, vol. 7, no. 12, e52605. [Online] DOI: https://doi.org/10.1371/journal.pone.0052605
  • Comley, LH, Fuller, HR, Wishart, TM, Mutsaers, CA, Thomson, D, Wright, AK, Ribchester, RR, Morris, GE, Parson, SH, Horsburgh, K & Gillingwater, TH 2011, 'ApoE isoform-specific regulation of regeneration in the peripheral nervous system', Human Molecular Genetics, vol. 20, no. 12, pp. 2406-2421. [Online] DOI: https://doi.org/10.1093/hmg/ddr147
  • Comley, LH, Wishart, TM, Baxter, B, Murray, LM, Nimmo, A, Thomson, D, Parson, SH & Gillingwater, TH 2011, 'Induction of cell stress in neurons from transgenic mice expressing yellow fluorescent protein: implications for neurodegeneration research', PloS ONE, vol. 6, no. 3, e17639. [Online] DOI: https://doi.org/10.1371/journal.pone.0017639
  • Mutsaers, CA, Wishart, TM, Lamont, DJ, Riessland, M, Schreml, J, Comley, LH, Murray, LM, Parson, SH, Lochmueller, H, Wirth, B, Talbot, K & Gillingwater, TH 2011, 'Reversible molecular pathology of skeletal muscle in spinal muscular atrophy', Human Molecular Genetics, vol. 20, no. 22, pp. 4334-4344. [Online] DOI: https://doi.org/10.1093/hmg/ddr360
  • Murray, LM, Comley, LH, Gillingwater, TH & Parson, SH 2011, 'The response of neuromuscular junctions to injury is developmentally regulated', The FASEB Journal, vol. 25, no. 4, pp. 1306-1313. [Online] DOI: https://doi.org/10.1096/fj.10-171934
  • Murray, LM, Lee, S, Baeumer, D, Parson, SH, Talbot, K & Gillingwater, TH 2010, 'Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy', Human Molecular Genetics, vol. 19, no. 3, pp. 420-433. [Online] DOI: https://doi.org/10.1093/hmg/ddp506
  • Wishart, TM, Huang, JP-W, Murray, LM, Lamont, DJ, Mutsaers, CA, Ross, J, Geldsetzer, P, Ansorge, O, Talbot, K, Parson, SH & Gillingwater, TH 2010, 'SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy', Human Molecular Genetics, vol. 19, no. 21, pp. 4216-4228. [Online] DOI: https://doi.org/10.1093/hmg/ddq340
  • Murray, LM, Gillingwater, TH & Parson, SH 2010, 'Using mouse cranial muscles to investigate neuromuscular pathology in vivo', Neuromuscular Disorders, vol. 20, no. 11, pp. 740-743. [Online] DOI: https://doi.org/10.1016/j.nmd.2010.06.013
  • Baxter, B, Gillingwater, TH & Parson, SH 2008, 'Rapid loss of motor nerve terminals following hypoxia-reperfusion injury occurs via mechanisms distinct from classic Wallerian degeneration', Journal of Anatomy, vol. 212, no. 6, pp. 827-835. [Online] DOI: https://doi.org/10.1111/j.1469-7580.2008.00909.x
  • Bettini, NL, Moores, TS, Baxter, B, Deuchars, J & Parson, SH 2007, 'Dynamic remodelling of synapses can occur in the absence of the parent cell body', BMC Neuroscience, vol. 8, 79. [Online] DOI: https://doi.org/10.1186/1471-2202-8-79
  • Brooke, RE, Atkinson, L, Edwards, I, Parson, SH & Deuchars, J 2006, 'Immunohistochemical localisation of the voltage gated potassium ion channel subunit Kv3.3 in the rat medulla oblongata and thoracic spinal cord', Brain Research, vol. 1070, no. 1, pp. 101-15. [Online] DOI: https://doi.org/10.1016/j.brainres.2005.10.102
  • Wishart, TM, Parson, SH & Gillingwater, TH 2006, 'Synaptic vulnerability in neurodegenerative disease', Journal of Neuropathology and Experimental Neurology, vol. 65, no. 8, pp. 733-739. [Online] DOI: https://doi.org/10.1097/01.jnen.0000228202.35163.c4
  • Baxter, RL, Vega-Riveroll, LJ, Deuchars, J & Parson, SH 2005, 'A2A adenosine receptors are located on presynaptic motor nerve terminals in the mouse', Synapse, vol. 57, no. 4, pp. 229-34. [Online] DOI: https://doi.org/10.1002/syn.20173
  • Dobrzynski, H, Li, J, Tellez, J, Greener, ID, Nikolski, VP, Wright, SE, Parson, SH, Jones, SA, Lancaster, MK, Yamamoto, M, Honjo, H, Takagishi, Y, Kodama, I, Efimov, IR, Billeter, R & Boyett, MR 2005, 'Computer three-dimensional reconstruction of the sinoatrial node', Circulation, vol. 111, no. 7, pp. 846-54. [Online] DOI: https://doi.org/10.1161/01.CIR.0000152100.04087.DB
  • Vega-Riveroll, LJ, Wylie, SR, Loughna, PT, Parson, SH & Chantler, PD 2005, 'Nonmuscle myosins IIA and IIB are present in adult motor nerve terminals', Neuroreport, vol. 16, no. 11, pp. 1143-6.
  • Moores, TS, Hasdemir, B, Vega-Riveroll, L, Deuchars, J & Parson, SH 2005, 'Properties of presynaptic P2X7-like receptors at the neuromuscular junction', Brain Research, vol. 1034, no. 1-2, pp. 40-50. [Online] DOI: https://doi.org/10.1016/j.brainres.2004.12.001
  • Parson, SH, Ribchester, RR, Davie, N, Gandhi, NP, Malik, RQ, Gillingwater, TH & Thomson, D 2004, 'Axotomy-dependent and -independent synapse elimination in organ cultures of Wld(s) mutant mouse skeletal muscle', Journal of neuroscience research, vol. 76, no. 1, pp. 64-75. [Online] DOI: https://doi.org/10.1002/jnr.20016
  • Brooke, RE, Moores, TS, Morris, NP, Parson, SH & Deuchars, J 2004, 'Kv3 voltage-gated potassium channels regulate neurotransmitter release from mouse motor nerve terminals', European Journal of Neuroscience, vol. 20, no. 12, pp. 3313-21. [Online] DOI: https://doi.org/10.1111/j.1460-9568.2004.03730.x
  • Deuchars, SA, Atkinson, L, Brooke, RE, Musa, H, Milligan, CJ, Batten, TF, Buckley, NJ, Parson, SH & Deuchars, J 2001, 'Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems', Journal of Neuroscience, vol. 21, no. 18, pp. 7143-52.
  • Parson, SH, Mackintosh, CL & Ribchester, RR 1997, 'Elimination of motor nerve terminals in neonatal mice expressing a gene for slow wallerian degeneration (C57Bl/Wlds)', European Journal of Neuroscience, vol. 9, no. 8, pp. 1586-1592. [Online] DOI: https://doi.org/10.1111/j.1460-9568.1997.tb01516.x
  • Parson, SH, Price, JF & Ribchester, RR 1995, 'Cell viability and laminin-induced neurite outgrowth in cultures of embryonic chick neural tube cells: effects of cytosine-B-D-arabinofuranoside', Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, vol. 4, no. 1, pp. 99-106.
  • Parson, SH & Sojitra, NM 1995, 'Loss of myelinated axons is specific to the central nervous system in a mouse model of the fetal alcohol syndrome', Journal of Anatomy, vol. 187 , no. 3, pp. 739-748.
  • Parson, SH, Dhillon, B, Findlater, GS & Kaufman, MH 1995, 'Optic nerve hypoplasia in the fetal alcohol syndrome: a mouse model', Journal of Anatomy, vol. 186 , no. 2, pp. 313-320.
  • Parson, SH & Ribchester, RR 1995, 'Segmental independence and age dependence of neurite outgrowth from embryonic chick sensory neurons', Journal of Neurobiology, vol. 26, no. 1, pp. 1-16. [Online] DOI: https://doi.org/10.1002/neu.480260102
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