Dr Roger Staff

Dr Roger Staff

Honorary Lecturer

Dr Roger Staff
Dr Roger Staff

Contact Details

The University of Aberdeen Nuclear Medicine ARI Foresterhill Aberdeen AB25 2ZD
Web Links






Roger Staff was born in London and studied physics at UEA.  He moved to Aberdeen in 1988 and completed his PhD in medical physics in 1994.  He has worked for the NHS since 1991 and currently leads the clinical physics imaging team at NHS-Grampian. His other interests include Intelligence and social mobility.


Research Interests

(Since 1999) founding member of the Aberdeen 1921 & 1936 birth cohort study group with three critical responsibilities for (1) hypothesis generation and hypothesis testing; (2) brain imaging and image analysis; (3) Advance data modelling of complex databases; (Since 2003 with Taurx) the imaging the effects tau aggregation inhibition and the use of surrogate imaging measures in drug development; (Since 2008) the development of structural and temporal (fMRI) complexity measures for use in ageing and neurodegenerative disease; (Since 2012) The prognostic value of automated analysis of sequential retinal images in diabetic retinopathy. The use of external quality assurance programs in diabetic retinopathy.   



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Page 1 of 2 Results 1 to 50 of 78

  • Khezrian, M, Waymont, JMJ, Myint, PK, McNeil, CJ, Whalley, L, Staff, R & Murray, AD 2020, 'Aspirin moderates the association between cardiovascular risk, brain white matter hyperintensity total lesion volume and processing speed in normal ageing', Maturitas, vol. 133, pp. 49-53. [Online] DOI: https://doi.org/10.1016/j.maturitas.2020.01.001
  • Shiells, H, Schelter, BO, Bentham, P, Baddeley, TC, Rubino, CM, Ganesan, H, Hammel, J, Vuksanovic, V, Staff, RT, Murray, AD, Bracoud, L, Wischik, DJ, Riedel, G, Gauthier, S, Jia, J, Moebius, HJ, Hardlund, J, Kipps, CM, Kook, K, Storey, JMD, Harrington, CR & Wischik, CM 2020, 'Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia', Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519. [Online] DOI: https://doi.org/10.3233/JAD-191173
  • de Vries, CF, Staff, R, Noble, KG, Muetzel, RL, Vernooij, MW, White, T, Waiter, GD & Murray, AD 2020, 'Klotho gene polymorphism, brain structure and cognition in early-life development', Brain Imaging and Behavior, vol. 14, pp. 213-225. [Online] DOI: https://doi.org/10.1007/s11682-018-9990-1
  • de Vries, C, Staff, RT, Waiter, GD, Sokunbi, MO, Sandu, AL & Murray, AD 2020, 'Motion during Acquisition is Associated with fMRI Brain Entropy', IEEE journal of biomedical and health informatics, vol. 24, no. 2, pp. 586-593. [Online] DOI: https://doi.org/10.1109/JBHI.2019.2907189
  • Schelter, BO, Shiells, HC, Baddeley, TC, Rubino, CM, Ganesan, H, Hammel, J, Vuksanovic, V, Staff, RT, Murray, AD, Bracoud, L, Riedel, G, Gauthier, S, Jia, J, Bentham, P, Kook, K, Storey, JMD, Harrington, CR & Wischik, CM 2019, 'Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease', Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946. [Online] DOI: https://doi.org/10.3233/JAD-190772
  • Vuksanovic, V, Staff, RT, Ahearn, T, Murray, AD & Wischik, CM 2019, 'Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia', International Journal of Neural Systems, vol. 29, no. 6, 1850055. [Online] DOI: https://doi.org/10.1142/S0129065718500557
  • Pitts, S, Philip, S, Prescott, G, Ahmed, A, Xu, J, Staff, R, Sharp, P & Olson, J 2018, 'Distribution of retinal microaneurysms in diabetic retinopathy using automated retinal image analysis', Diabetic Medicine, vol. 35, no. S1, P466, pp. 182. [Online] DOI: https://doi.org/10.1111/dme.53_13571
  • McNeil, CJ, Myint, PK, Sandu-Giuraniuc, A-L, Potter, JF, Staff, R, Whalley, LJ & Murray, AD 2018, 'Increased diastolic blood pressure is associated with MRI biomarkers of dementia-related brain pathology in normative ageing', Age and Ageing, vol. 47, no. 1, pp. 95-100. [Online] DOI: https://doi.org/10.1093/ageing/afx102
  • Staff, RT, Hogan, MJ, Williams, DS & Whalley, LJ 2018, 'Intellectual engagement and cognitive ability in later life (the "use it or lose it" conjecture): Longitudinal, prospective study', BMJ (Online), vol. 363, k4925. [Online] DOI: https://doi.org/10.1136/bmj.k4925
  • Chapko, D, McCormack, R, Black, C, Staff, R & Murray, A 2018, 'Life-course determinants of cognitive reserve (CR) in cognitive aging and dementia: a systematic literature review', Aging & Mental Health, vol. 22, no. 8, pp. 915-926. [Online] DOI: https://doi.org/10.1080/13607863.2017.1348471
  • Staff, RT, Hogan, MJ & Whalley, LJ 2018, 'The influence of childhood intelligence, social class, education and social mobility on memory and memory decline in late life', Age and Ageing, vol. 47, no. 6, pp. 847-852. [Online] DOI: https://doi.org/10.1093/ageing/afy111
  • Job, DE, Dickie, DA, Rodriguez, D, Robson, A, Pernet, C, Bastin, ME, Boardman, JP, Murray, AD, Ahearn, T, Waiter, GD, Staff, RT, Deary, IJ, Shenkin, SD & Wardlaw, JM 2017, 'A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)', Neuroimage, vol. 144, no. Part B, pp. 299–304. [Online] DOI: https://doi.org/10.1016/j.neuroimage.2016.01.027
  • Staff, RT, Hogan, MJ & Whalley, LJ 2017, 'Childhood intelligence and personality traits neuroticism and openness contributes to social mobility: A study in the Aberdeen 1936 Birth Cohort', Personality and Individual Differences, vol. 114, pp. 206-212. [Online] DOI: https://doi.org/10.1016/j.paid.2017.02.068
  • Vuksanovic, V, Staff, R, Ahearn, TS, Morson, SM, Bentham, P, Murray, AD & Wischik, CM 2017, 'Distinct anatomical subtypes of behavioural variant frontotemporal dementia and involvement of intrinsic brain networks: a clustering study', Alzheimer Research UK (2017), 14/03/17.
  • de Vries, CF, Staff, RT, Harris, SE, Chapko, D, Williams, DS, Reichert, P, Ahearn, T, McNeil, CJ, Whalley, LJ & Murray, AD 2017, 'Klotho, APOEε4, cognitive ability, brain size, atrophy and survival: A study in the Aberdeen Birth Cohort of 1936', Neurobiology of Aging, vol. 55, pp. 91-98. [Online] DOI: https://doi.org/10.1016/j.neurobiolaging.2017.02.019
  • Vuksanovic, V, Staff, R, Ahearn, T, Bentham, P, Murray, AD & Wischik, CM 2017, 'Organisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes', 6th Cambridge Neuroscience Symposium, Cambridge, United Kingdom, 7/09/17 - 8/09/17.
  • Wilcock, GK, Gauthier, S, Frisoni, GB, Jia, J, Hardlund, JH, Moebius, HJ, Bentham, P, Kook, KA, Schelter, BO, Wischik, DJ, Davis, CS, Staff, RT, Vuksanovic, V, Ahearn, T, Bracoud, L, Shamsi, K, Marek, K, Seibyl, J, Riedel, G, Storey, JMD, Harrington, CR & Wischik, CM 2017, 'Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial', Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457. [Online] DOI: https://doi.org/10.3233/JAD-170560
  • Sandu-Giuraniuc, A-L, Staff, R, McNeil, CJ, Stringer, MS, Ahearn, T, Whalley, L & Murray, AD 2017, 'Sexual dimorphism in changes of cortical complexity associated with cognitive decline in late life', Alzheimer's Research UK, Aberdeen, United Kingdom, 14/03/17 - 15/03/17.
  • Murray, A, McNeil, C, Salarirad, S, Deary, I, Phillips, L, Whalley, L & Staff, R 2016, 'Brain hyperintensity location determines outcome in the triad of impaired cognition, physical health and depressive symptoms: A cohort study in late life', Archives of Gerontology and Geriatrics, vol. 63, pp. 49-54. [Online] DOI: https://doi.org/10.1016/j.archger.2015.10.004
  • Whalley, LJ, Staff, RT, Fox, HC & Murray, AD 2016, 'Cerebral correlates of cognitive reserve', Psychiatry Research, vol. 247, pp. 65-70. [Online] DOI: https://doi.org/10.1016/j.pscychresns.2015.10.012
  • Gauthier, S, Feldman, HH, Schneider, LS, Wilcock, GK, Frisoni, GB, Hardlund, JH, Moebius, HJ, Bentham, P, Kook, KA, Wischik, DJ, Schelter, BO, Davis, CS, Staff, RT, Bracoud, L, Shamsi, K, Storey, JMD, Harrington, CR & Wischik, CM 2016, 'Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial ', The Lancet, vol. 388, no. 10062, pp. 2873-2884. [Online] DOI: https://doi.org/10.1016/S0140-6736(16)31275-2
  • Chapko, D, Staff, RT, McNeil, CJ, Whalley, LJ, Black, C & Murray, AD 2016, 'Late-life deficits in cognitive, physical and emotional functions, childhood intelligence and occupational profile: a life-course examination of the Aberdeen 1936 Birth Cohort (ABC1936)', Age and Ageing, vol. 45, no. 4, pp. 486-493. [Online] DOI: https://doi.org/10.1093/ageing/afw061
  • Vuksanovic, V, Staff, R, Ahearn, T, Morson, SM, Bentham, P, Murray, AD & Wischik, CM 2016, 'Neural correlates of cognitive and behavioural impairments in behavioural variant of frontotemporal dementia: A voxel based morphometry analysis', SINAPSE Annual Scientific Meeting (2016), Stirling, United Kingdom, 17/06/16.
  • Sandu-Giuraniuc, A-L, Rana, A, Robertson, KL, Ahearn, T, McNeil, CJ, Staff, R & Murray, AD 2015, 'A longitudinal study of cognitive and hippocampal ageing in late life', British Neuroscience Association, 2015 Festival of Neuroscience, Edinburgh, United Kingdom, 12/04/15 - 15/04/15.
  • Sokunbi, MO, Cameron, GG, Ahearn, TS, Murray, AD & Staff, RT 2015, 'Fuzzy approximate entropy analysis of resting state fMRI signal complexity across the adult life span', Medical Engineering & Physics, vol. 37, no. 11, pp. 1082-1090. [Online] DOI: https://doi.org/10.1016/j.medengphy.2015.09.001
  • Sandu-Giuraniuc, A-L, McNeil, CJ, Stringer, M, Ahearn, T, Whalley, L, Staff, R & Murray, AD 2015, 'Mapping the cortical complexity and cognitive decline in late life', Alzheimer's research UK 2015, London, United Kingdom, 10/03/15 - 11/03/15.
  • Wischik, CM, Harbaran, DV, Riedel, G, Deiana, S, Goatman, EA, Wischik, DJ, Murray, AD & Staff, RT Dec. 15 2015, Phenothiazine compounds for treating mild cognitive impairment, Patent No. US9211294.
  • Wischik, CM, Staff, RT, Wischik, DJ, Bentham, P, Murray, AD, Storey, JMD, Kook, KA & Harrington, CR 2015, 'Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease', Journal of Alzheimer's Disease, vol. 44, no. 2, pp. 705-720. [Online] DOI: https://doi.org/10.3233/JAD-142874
  • Sandu-Giuraniuc, A-L, Staff, R, McNeil, CJ, Mustafa, N, Ahearn, T, Whalley, L & Murray, AD 2014, 'A longitudinal study of human brain complexity and cognitive decline in ageing', Organization of Human Brain Mapping meeting (OHBM), Hamburgh, Germany, 8/06/14 - 12/06/14. <> [Online] DOI: https://f1000research.com/posters/1096705
  • Murray, AD, McNeil, CJ, Salarirad, S, Whalley, LJ & Staff, RT 2014, 'Early life socioeconomic circumstances and late life brain hyperintensities: a population based cohort study', PloS ONE, vol. 9, no. 2, e88969. [Online] DOI: https://doi.org/10.1371/journal.pone.0088969
  • Whalley, LJ, Duthie, SJ, Collins, AR, Starr, JM, Deary, IJ, Lemmon, H, Duthie, AC, Murray, AD & Staff, RT 2014, 'Homocysteine, antioxidant micronutrients and late onset dementia', European Journal of Nutrition, vol. 53, no. 1, pp. 277-285. [Online] DOI: https://doi.org/10.1007/s00394-013-0526-6
  • Prescott, G, Sharp, P, Goatman, K, Scotland, G, Fleming, A, Philip, S, Staff, R, Santiago, C, Borooah, S, Broadbent, D, Chong, V, Dodson, P, Harding, S, Leese, G, Megaw, R, Styles, C, Swa, K, Wharton, H & Olson, J 2014, 'Improving the cost-effectiveness of photographic screening for diabetic macular oedema: a prospective, multi-centre, UK study', British Journal of Ophthalmology, vol. 98, no. 8, pp. 1042-1049. [Online] DOI: https://doi.org/10.1136/bjophthalmol-2013-304338
  • Sokunbi, MO, Gradin, VB, Waiter, GD, Cameron, GG, Ahearn, TS, Murray, AD, Steele, DJ & Staff, RT 2014, 'Nonlinear complexity analysis of brain FMRI signals in schizophrenia', PloS ONE, vol. 9, no. 5, e95146. [Online] DOI: https://doi.org/10.1371/journal.pone.0095146
  • Sandu-Giuraniuc, A-L, Staff, RT, McNeil, CJ, Mustafa, N, Ahearn, T, Whalley, LJ & Murray, AD 2014, 'Structural brain complexity and cognitive decline in late life: A longitudinal study in the Aberdeen 1936 Birth Cohort', Neuroimage, vol. 100, pp. 558-563. [Online] DOI: https://doi.org/10.1016/j.neuroimage.2014.06.054
  • Murray, AD, Staff, RT, McNeil, CJ, Salarirad, S, Phillips, LH, Starr, J, Deary, IJ & Whalley, LJ 2013, 'Depressive symptoms in late life and cerebrovascular disease: the importance of intelligence and lesion location', Depression and Anxiety, vol. 30, no. 1, pp. 77-84. [Online] DOI: https://doi.org/10.1002/da.22022
  • Whalley, LJ, Staff, RT, Murray, AD, Deary, IJ & Starr, JM 2013, 'Genetic and environmental factors in late onset dementia: possible role for early parental death', International Journal of Geriatric Psychiatry, vol. 28, no. 1, pp. 75-81. [Online] DOI: https://doi.org/10.1002/gps.3792
  • Whalley, LJ, Sharma, S, Fox, HC, Murray, AD, Staff, RT, Duthie, AC, Deary, IJ & Starr, JM 2012, 'Anticholinergic drugs in late life: adverse effects on cognition but not on progress to dementia', Journal of Alzheimer's Disease, vol. 30, no. 2, pp. 253-261. [Online] DOI: https://doi.org/10.3233/JAD-2012-110935
  • Murray, AD, Staff, RT, McNeil, CJ, Salarirad, S, Starr, JM, Deary, IJ & Whalley, LJ 2012, 'Brain lesions, hypertension and cognitive aging in the 1921 and 1936 Aberdeen birth cohorts', Age, vol. 34, no. 2, pp. 451-459. [Online] DOI: https://doi.org/10.1007/s11357-011-9233-5
  • Mustafa, N, Ahearn, TS, Waiter, GD, Murray, AD, Whalley, LJ & Staff, RT 2012, 'Brain structural complexity and life course cognitive change', Neuroimage, vol. 61, no. 3, pp. 694-701. [Online] DOI: https://doi.org/10.1016/j.neuroimage.2012.03.088
  • Staff, RT, Murray, AD, Ahearn, TS, Mustafa, N, Fox, HC & Whalley, LJ 2012, 'Childhood socioeconomic status and adult brain size: Childhood socioeconomic status influences adult hippocampal size', Annals of Neurology, vol. 71, no. 5, pp. 653-660. [Online] DOI: https://doi.org/10.1002/ana.22631
  • Dickie, DA, Job, DE, Poole, I, Ahearn, TS, Staff, RT, Murray, AD & Wardlaw, JM 2012, 'Do brain image databanks support understanding of normal ageing brain structure? A systematic review', European Radiology, vol. 22, no. 7, pp. 1385-1394. [Online] DOI: https://doi.org/10.1007/s00330-012-2392-7
  • Hogan, MJ, Staff, RT, Bunting, BP, Murray, AD, Ahearn, TS, Deary, IJ & Whalley, LJ 2011, 'Cerebellar brain volume accounts for variance in cognitive performance in older adults', Cortex, vol. 47, no. 4, pp. 441-450. [Online] DOI: https://doi.org/10.1016/j.cortex.2010.01.001
  • Salarirad, S, Staff, RT, Fox, HC, Deary, IJ, Whalley, L & Murray, AD 2011, 'Childhood intelligence and brain white matter hyperintensities predict fluid intelligence age 78-81 years: a 1921 Aberdeen birth cohort study', Age and Ageing, vol. 40, no. 5, pp. 562-567. [Online] DOI: https://doi.org/10.1093/ageing/afr065
  • Whalley, LJ, Murray, AD, Staff, RT, Starr, JM, Deary, IJ, Fox, HC, Lemmon, H, Duthie, SJ, Collins, AR & Crawford, JR 2011, 'How the 1932 and 1947 mental surveys of Aberdeen schoolchildren provide a framework to explore the childhood origins of late onset disease and disability', Maturitas, vol. 69, no. 4, pp. 365-372. [Online] DOI: https://doi.org/10.1016/j.maturitas.2011.05.010
  • Sokunbi, MO, Staff, RT, Waiter, GD, Ahearn, TS, Fox, HC, Deary, IJ, Starr, JM, Whalley, LJ & Murray, AD 2011, 'Inter-individual differences in fMRI entropy measurements in old age', IEEE Transactions on Biomedical Engineering, vol. 58, no. 11, pp. 3206-3214. [Online] DOI: https://doi.org/10.1109/TBME.2011.2164793
  • Reilly, TJ, Staff, RT, Ahearn, TS, Bentham, P, Wischik, CM & Murray, AD 2011, 'Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease', Behavioural Brain Research, vol. 222, no. 2, pp. 375-379. [Online] DOI: https://doi.org/10.1016/j.bbr.2011.04.003
  • Murray, AD, Staff, RT, McNeil, CJ, Salarirad, S, Ahearn, TS, Mustafa, N & Whalley, LJ 2011, 'The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases', Brain, vol. 134, no. 12, pp. 3687-3696. [Online] DOI: https://doi.org/10.1093/brain/awr259
  • Staff, R, Ahearn, TS, Phillips, LH, Cooper, CL, Mowat, D, Wischik, CM, Whalley, LJ & Murray, AD 2011, 'The cerebral blood flow correlates of emotional facial processing in mild Alzheimer's disease', Neuroscience & Medicine, vol. 2, no. 1, pp. 6-13. [Online] DOI: https://doi.org/10.4236/nm.2011.21002
  • Staff, RT, Murray, AD, Ahearn, T, Salarirad, S, Mowat, D, Starr, JM, Deary, IJ, Lemmon, H & Whalley, LJ 2010, 'Brain volume and survival from age 78 to 85: the contribution of Alzheimer-type magnetic resonance imaging findings', Journal of the American Geriatrics Society, vol. 58, no. 4, pp. 688-695. [Online] DOI: https://doi.org/10.1111/j.1532-5415.2010.02765.x
  • Peare, R, Staff, RT & Heys, SD 2010, 'The use of FDG-PET in assessing axillary lymph node status in breast cancer: a systematic review and meta-analysis of the literature ', Breast Cancer Research and Treatment, vol. 123, no. 1, pp. 281-290. [Online] DOI: https://doi.org/10.1007/s10549-010-0771-9
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