Dr Seonaidh Cotton

Dr Seonaidh Cotton
BSc (Hons), MLitt, PhD

Senior Trial Manager

Overview
Dr Seonaidh Cotton
Dr Seonaidh Cotton

Contact Details

Telephone
work +44 (0)1224 438178
Fax
fax 01224 438165
Email
Address
The University of Aberdeen Health Services Research Unit Health Sciences Building (Third Floor) Foresterhill Aberdeen AB25 2ZD

Biography

I joined HSRU in 2007 as a trial manager.  I graduated from the University of Aberdeen with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007.  Prior to joining the Unit, I worked in the Department of Public Health at the University of Aberdeen.

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENOEMPOWER and ELECTRIC (all now completed).  I also worked as trial manager on a number of CHaRT trials, including TWICSCLASSNIAMIFOCCUSREFLUX and the Cysteamine in CF study.  

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

 


Qualifications

PhD, Public Health University of Aberdeen 2008
MLitt, by research University of Aberdeen 1994
BSc, Health Sciences University of Aberdeen 1993
Research

Research Areas


Research Overview

Trial methodology & trial management


Current Research

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.


Past Research

Since joining the Unit I have worked on a number of trials that have now been completed. 

TWICS  - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.

CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;

NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;

FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery

REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.

The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.

I also supported RAACENOEMPOWER and ELECTRIC (all now completed) as senior trial manager.

Teaching

Courses


Teaching Responsibilities

I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.

 

 


Non-Course Teaching Responsibilities

Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC).

 

Publications

Publications 

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  • Has the human papillomavirus (HPV) immunization programme improved obstetric outcomes in spontaneous delivery?: An ecological study

    Xu, X., Woolner, A., Bhattacharya, S., Cotton, S., Zhao, F., Cruickshank, M.

    European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 262, pp. 221-227

    Contributions to Journals: Articles

  • Tibial nerve stimulation compared with sham to reduce incontinence in care home residents: ELECTRIC RCT

    Booth, J., Aucott, L., Cotton, S., Davis, B., Fenocchi, L., Goodman, C., Hagen, S., Harari, D., Lawrence, M., Lowndes, A., Macaulay, L., MacLennan, G., Mason, H., McClurg, D., Norrie, J., Norton, C., O'Dolan, C., Skelton, D., Surr, C., Treweek, S.

    Health technology assessment (Winchester, England), vol. 25, no. 41

    Contributions to Journals: Articles

  • Providing trial results to participants in Phase III pragmatic effectiveness RCTs: a scoping review

    Bruhn, H., Cowan, E., Campbell, M., Constable, L., Cotton, S., Entwistle, V., Humphreys, R., Innes, K., Jayacodi, S., Jayacodi, S., Knapp, P., South, A., Gillies, K.

    Trials, vol. 22, no. 1, 361

    Contributions to Journals: Articles

  • Developing the INCLUDE Ethnicity Framework: a tool to help trialists design trials that better reflect the communities they serve

    Treweek, S., Banister, K., Bower, P., Cotton, S., Devane, D., Gardner, H., Isaacs, T., Nestor, G., Oshisanya, A., Parker, A., Rochester, L., Soulsby, I., Williams, H. C., Witham, M. D.

    Trials, vol. 22, 337

    Contributions to Journals: Articles

  • It is unprecedented: trial management during the COVID-19 pandemic and beyond

    Mitchell, E. J., Ahmed, K., Breeman, S., Cotton, S., Constable, L., Ferry, G., Goodman, K., Hickey, H., Meakin, G., Mironov, K., Quann, N., Wakefield, N., McDonald, A.

    Trials, vol. 21, pp. 784

    Contributions to Journals: Articles

  • Using systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project

    Crowley, E., Treweek, S., Banister, K., Breeman, S., Constable, L., Cotton, S., Duncan, A., El Feky, A., Gardner, H., Goodman, K., Lanz, D., McDonald, A., Ogburn, E., Starr, K., Stevens, N., Valente, M., Fernie, G.

    Trials, vol. 21, no. 1, pp. 535

    Contributions to Journals: Articles

  • Trial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed

    Treweek, S., Bevan, S., Bower, P., Briel, M., Campbell, M., Christie, J., Collett, C., Cotton, S., Devane, D., El Feky, A., Galvin, S., Gardner, H., Gillies, K., Hood, K., Jansen, J., Littleford, R., Parker, A., Ramsay, C., Restrup, L., Sullivan, F., Torgerson, D., Tremain, L., von Elm, E., Westmore, M., Williams, H., Williamson, P. R., Clarke, M.

    Trials, vol. 21, 33

    Contributions to Journals: Articles

  • ELECtric Tibial nerve stimulation to Reduce Incontinence in Care homes: protocol for the ELECTRIC randomised trial

    Booth, J., Aucott, L., Cotton, S., Goodman, C., Hagen, S., Harari, D., Lawrence, M., Lowndes, A., Macaulay, L., MacLennan, G., Mason, H., McClurg, D., Norrie, J., Norton, C., O'Dolan, C., Skelton, D. A., Surr, C., Treweek, S.

    Trials, vol. 20, 723

    Contributions to Journals: Articles

  • Five-Year Outcomes of a Randomized Trial of Treatments for Varicose Veins

    Brittenden, J., Cooper, D., Dimitrova, M., Scotland, G., Cotton, S. C., Elders, A., MacLennan, G., Ramsay, C. R., Norrie, J., Burr, J. M., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., Tassie, E., Francis, J., Campbell, M. K.

    The New England Journal of Medicine, vol. 381, no. 10, pp. 912-922

    Contributions to Journals: Articles

  • Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: a RCT

    Devereux, G., Cotton, S., Fielding, S., McMeekin, N., Barnes, P. J., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., Soyza, A. D., Gompertz, S., Haughney, J., Innes, K., Kaniewska, J., Lee, A., Morice, A., Norrie, J., Sullivan, A., Wilson, A., Price, D.

    Health technology assessment (Winchester, England), vol. 23, no. 37, pp. 1-146

    Contributions to Journals: Articles

  • Estimating Site Performance (ESP): can trial managers predict recruitment success at trial sites? An exploratory study

    Bruhn, H., Treweek, S., Duncan, A., Shearer, K., Cameron, S., Campbell, K., Innes, K., McRae, D., Cotton, S. C.

    Trials, vol. 20, 192

    Contributions to Journals: Articles

  • Reducing Asthma Attacks in Children using Exhaled Nitric Oxide as a biomarker to inform treatment strategy: a randomised trial (RAACENO)

    Turner, S., Cotton, S. C., Emele, C. D., Thomas, R. E., Fielding, S. A., Gaillard, E. A., de Jongste, J. C., Morgan, H. M., Nielson, A. R., Norrie, J., Pijnenburg, M. W., Price, D. B., Thomas, M.

    Trials, vol. 20, 573

    Contributions to Journals: Articles

  • Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial

    Devereux, G., Cotton, S., Fielding, S., McMeekin, N., Barnes, P. J., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., De Soyza, A., Gompertz, S., Haughney, J., Innes, K., Kaniewska, J., Lee, A., Morice, A., Norrie, J., Sullivan, A., Wilson, A., Price, D.

    JAMA, vol. 320, no. 15, pp. 1548-1559

    Contributions to Journals: Articles

  • Use of 'Low-Dose' Theophylline to Reduce Exacerbations of COPD: A Pragmatic Multicentre Randomised Placebo Controlled Trial

    Price, D. B., Cotton, S., Fielding, S., McMeekin, N., Barnes, P., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., De Soyza, A., Gompertz, S., Haughney, J., Lee, A., Morice, A., Norrie, J., Sullivan, A., Wilson, A., Devereux, G.

    American Thoracic Society 2018 International Conference, A7709

    Contributions to Journals: Abstracts

  • Trial Forge Guidance 1: What is a Study Within A Trial (SWAT)

    Treweek, S., Bevan, S., Bower, P., Campbell, M., Christie, J., Clarke, M., Collett, C., Cotton, S. C., Devane, D., El Feky, A., Flemyng, E., Galvin, S., Gardner, H. R., Gillies, K., Jansen, J., Littleford, R., Parker, A., Ramsay, C., Restrup, L., Sullivan, F., Torgerson, D., Tremain, L., Westmore, M., Williamson, P. R.

    Trials, vol. 19, 139

    Contributions to Journals: Letters

  • The influence of early research experience in medical school on the decision to intercalate and future career in clinical academia: A questionnaire study

    Boyle, S. E., Cotton, S. C., Myint, P. K., Hold, G. L.

    BMC Medical Education, vol. 17, 245

    Contributions to Journals: Articles

  • Reduction in colposcopy workload and associated clinical activity following HPV catch-up vaccination programme in Scotland: an ecological study

    Cruickshank, M. E., Pan, J., Cotton, S. C., Kavanagh, K., Robertson, C., Cuschieri, K., Cubie, H., Palmer, T., Pollock, K. G.

    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 124, no. 9, pp. 1386-1393

    Contributions to Journals: Articles

  • The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two centre observational study

    Munro, A., Gillespie, C., Cotton, S., Busby-Earle, C., Kavanagh, K., Cuschieri, K., Cubie, H., Robertson, C., Smart, L., Pollock, K., Moore, C., Palmer, T., Cruickshank, M. E.

    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 124, no. 9, pp. 1394-1401

    Contributions to Journals: Articles

  • Psychosocial morbidity in women with abnormal cervical cytology managed by cytological surveillance or initial colposcopy: longitudinal analysis from the TOMBOLA randomised trial

    Fielding, S., Rothnie, K., Gray, N. M., Little, J., Cruickshank, M., Neal, K., Walker, L., Whynes, D., Cotton, S., Sharp, L.

    Psycho-Oncology, vol. 26, no. 4, pp. 476–483

    Contributions to Journals: Articles

  • An Open-Label Investigation of the Pharmacokinetics and Tolerability of Oral Cysteamine in Adults with Cystic Fibrosis

    Devereux, G., Steele, S., Griffiths, K., Devlin, E., Fraser-Pitt, D., Cotton, S., Norrie, J., Chrystyn, H., O'Neil, D.

    Clinical Drug Investigation, vol. 36, no. 8, pp. 605-612

    Contributions to Journals: Articles

  • HPV immunisation and cervical screening - confirmation of changed performance of cytology as a screening test in immunised women: a retrospective population based cohort study

    Palmer, T. J., McFadden, M., Pollock, K. G. J., Kavanagh, K., Cuschieri, K., Cruickshank, M., Cotton, S., Nicoll, S., Robertson, C.

    British Journal of Cancer, vol. 114, no. 5, pp. 582-589

    Contributions to Journals: Articles

  • Impact of post-colposcopy management on women's long-term worries: results from the UK population-based TOMBOLA trial

    Sharp, L., Cotton, S., Cruickshank, M., Gray, N., Smart, L., Whynes, D., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    Journal of Family Planning and Reproductive Health Care, vol. 42, no. 1, pp. 43-51

    Contributions to Journals: Articles

  • Long-term Worries after Colposcopy: Which Women Are at Increased Risk?

    Sharp, L., Cotton, S. C., Cruickshank, M. E., Gray, N. M., Neal, K., Rothnie, K., Thornton, A. J., Walker, L. G., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    Women's Health Issues, vol. 25, no. 5, pp. 517-527

    Contributions to Journals: Articles

  • Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial

    Devereux, G., Cotton, S., Barnes, P., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J. A. F., Lee, A. J., McCormack, K., McPherson, G., Morice, A., Norrie, J., Sullivan, A., Wilson, A., Price, D.

    Trials, vol. 16, 267

    Contributions to Journals: Articles

  • Making randomised trials more efficient: report of the first meeting to discuss the Trial Forge platform

    Treweek, S., Altman, D. G., Bower, P., Campbell, M., Chalmers, I., Cotton, S., Craig, P., Crosby, D., Davidson, P., Devane, D., Duley, L., Dunn, J., Elbourne, D., Farrell, B., Gamble, C., Gillies, K., Hood, K., Lang, T., Littleford, R., Loudon, K., McDonald, A., McPherson, G., Nelson, A., Norrie, J., Ramsay, C., Sandercock, P., Shanahan, D. R., Summerskill, W., Sydes, M., Williamson, P., Clarke, M.

    Trials, vol. 16, 261

    Contributions to Journals: Articles

  • A normal colposcopy examination fails to provide psychological reassurance for women who have had low-grade abnormal cervical cytology

    Cotton, S. C., Sharp, L., Little, J., Gray, N. M., Walker, L. G., Whynes, D. K., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    Cytopathology, vol. 26, no. 3, pp. 178-187

    Contributions to Journals: Articles

  • Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial

    Brittenden, J., Cotton, S. C., Elders, A., Tassie, E., Scotland, G., Ramsay, C. R., Norrie, J., Burr, J., Francis, J., Wileman, S., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., MacLennan, G., Prior, M., Bolsover, D., Campbell, M. K.

    Health Technology Assessment, vol. 19, no. 27, pp. 1-342

    Contributions to Journals: Articles

  • Management of women with low grade cytology: how reassuring is a normal colposcopy examination?

    Cruickshank, M. E., Cotton, S. C., Sharp, L., Smart, L., Walker, L. G., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 122, no. 3, pp. 380-386

    Contributions to Journals: Articles

  • Measuring the psychosocial burden in women with low-grade abnormal cervical cytology in the TOMBOLA trial: psychometric properties of the Process and Outcome Specific Measure (POSM)

    Rothnie, K., Cotton, S. C., Fielding, S., Gray, N. M., Little, J., Cruickshank, M. E., Walker, L. G., Avis, M., Sharp, L.

    Health and Quality of Life Outcomes, vol. 12, 154

    Contributions to Journals: Articles

  • Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial

    Tassie, E., Scotland, G., Brittenden, J., Cotton, S. C., Elders, A., Campbell, M. K., Campbell, B., Gough, M., Burr, J. M., Ramsay, C. R., CLASS Study Team

    British Journal of Surgery, vol. 101, no. 12, pp. 1532-1540

    Contributions to Journals: Articles

  • A randomized trial comparing treatments for varicose veins

    Brittenden, J., Cotton, S. C., Elders, A., Ramsay, C. R., Norrie, J., Burr, J., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., Francis, J., Tassie, E., Scotland, G., Wileman, S., Campbell, M. K.

    The New England Journal of Medicine, vol. 371, no. 13, pp. 1218-1227

    Contributions to Journals: Articles

  • Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

    Siddiqi, N., Neil, C., Bruce, M., Maclennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J. C., Frenneaux, M., NIAMI investigators

    European Heart Journal, vol. 35, no. 19, pp. 1255-1262

    Contributions to Journals: Articles

  • The unintended consequences of cervical screening: distress in women undergoing cytologic surveillance

    Sharp, L., Cotton, S., Cruickshank, M., Gray, N. M., Harrild, K., Smart, L., Walker, L. G., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    Journal of Lower Genital Tract Disease, vol. 18, no. 2, pp. 142-150

    Contributions to Journals: Articles

  • Nitrites in Acute Myocardial Infarction

    Siddiqi, N., Bruce, M., Neil, C. J., MacLennan, G., Cotton, S., Papadopoulou, S. A., Jagpal, B., Brown, S., Gonzalez, F. P., Singh, S., Schwarz, K., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J., Frenneaux, M. P.

    Circulation, vol. 128, no. 24, pp. 2705

    Contributions to Journals: Abstracts

  • Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy

    Whynes, D. K., Sharp, L., Cotton, S. C., Cruickshank, M., Gray, N. M., Little, J., Waugh, N.

    European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 169, no. 1, pp. 88-92

    Contributions to Journals: Articles

  • Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial)

    Grant, A. M., Boachie, C., Cotton, S. C., Faria, R., Bojke, L., Epstein, D. M., Ramsay, C. R., Corbacho, B., Sculpher, M., Krukowski, Z. H., Heading, R. C., Campbell, M. K.

    Health Technology Assessment, vol. 17, no. 22, pp. 1-166

    Contributions to Journals: Articles

  • Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)

    Siddiqi, N., Bruce, M., Neil, C. J., Jagpal, B., MacLennan, G. S., Cotton, S. C., Papadopoulo, S. A., Bunce, N., Lim, P., Schwarz, K., Singh, S., Hildick-Smith, D., Horowitz, J. D., Madhani, M., Boon, N., Kaski, J., Dawson, D., Frenneaux, M. P.

    Journal of translational medicine, vol. 11, 116

    Contributions to Journals: Articles

  • Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX)

    Grant, A. M., Cotton, S. C., Boachie, C., Ramsay, C. R., Krukowski, Z. H., Heading, R. C., Campbell, M. K., REFLUX Trial Group

    BMJ, vol. 346, f1908

    Contributions to Journals: Articles

  • Which women default from follow-up cervical cytology tests? A cohort study within the TOMBOLA trial

    Sharp, L., Cotton, S., Thornton, A., Gray, N., Whynes, D., Smart, L., Waugh, N., Duncan, I., Cruickshank, M., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    Cytopathology, vol. 23, no. 3, pp. 150-160

    Contributions to Journals: Articles

  • A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery: the FOCCUS study

    Cuthbertson, B. H., Campbell, M. K., Stott, S. A., Elders, A., Hernández, R., Boyers, D., Norrie, J., Kinsella, J., Brittenden, J., Cook, J., Rae, D., Cotton, S. C., Alcorn, D., Addison, J., Grant, A., The FOCCUS study group

    Critical Care, vol. 15, no. 6, R296

    Contributions to Journals: Articles

  • Human papillomavirus infection and anxiety: analyses in women with low-grade cervical cytological abnormalities unaware of their infection status

    Johnson, C. Y., Sharp, L., Cotton, S. C., Harris, C. A., Gray, N. M., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    PloS ONE, vol. 6, no. 6, e21046

    Contributions to Journals: Articles

  • Long-term psychosocial impact of alternative management policies in women with low-grade abnormal cervical cytology referred for colposcopy: a randomised controlled trial

    Sharp, L., Cotton, S., Gray, N., Avis, M., Russell, I., Walker, L., Waugh, N., Whynes, D., Woolley, C., Thornton, A. J., Smart, L., Cruickshank, M., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    British Journal of Cancer, vol. 104, no. 2, pp. 255-264

    Contributions to Journals: Articles

  • The role of human papillomavirus testing in the management of women with low-grade abnormalities: multicentre randomised controlled trial

    Cotton, S., Sharp, L., Little, J., Cruickshank, M., Seth, R., Smart, L., Duncan, I., Harrild, K., Neal, K., Waugh, N., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 117, no. 6, pp. 645-659

    Contributions to Journals: Articles

  • Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery

    Cuthbertson, B., Campbell, M. K., Stott, S., Vale, L. D., Norrie, J. D. T., Kinsella, J., Cook, J. A., Brittenden, J., Grant, A. M., Alcorn, D., Serpell, M., McColl, S., Rae, D., Shepherd, K., Addison, J., McPherson, G. C., McDonald, A. M., Cotton, S. C., Elders, A. S., MacLennan, G. S., Boyers, D., Hernández, R. A.

    Edinburgh, United Kingdom: Chief Scientist Office. 7 pages

    Books and Reports: Commissioned Reports

  • After-effects reported by women following colposcopy, cervical biopsies and LLETZ: results from the TOMBOLA trial

    Sharp, L., Cotton, S. C., Cochran, C., Gray, N. M., Little, J., Neal, K., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 116, no. 11, pp. 1506-1514

    Contributions to Journals: Articles

  • Comprehensive cancer control-research & development: Knowing what we do and doing what we know

    Kerner, J. F., Cazap, E., Yach, D., Pierotti, M. A., Daidone, M. G., De Blasio, P., Geary, P., Schacter, B., Sant, M., Habbema, J. D. F., Sankaranarayanan, R., Sutcliffe, C., Sutcliffe, S., Kaijage, J. K., Scanlan, P. A., Gibson, S., Mes-Masson, A. M., Sawyer, M., Shepherd, L., Watson, P., Zanke, B., Small, I. A., Olmedo, D. B., Breitenbach, M. D., Santini, L. A., Maltoni, L. A., Ramalho, D., Ferreira, C. G., Sharp, L., Cruickshank, M., Smart, L., Harrild, K., Waugh, N., Little, J., Seth, R., Neal, K., Duncan, I., Ioka, A., Ito, Y., Sato, N., Tsukuma, H., Li, J., Zhang, B. N., Fan, J. H., Qiao, Y. L., Zhong, H. Y., Curado, M. P., Pontes, T. J., Peacock, S., Van Der Hoek, K., Hoch, J., Musa, Z., Weir, H. K., Friedman, C., German, R., Ceilleachair, A. O., Comber, H., Cotton, S., Tilson, L., Walsh, C., Usher, C., Barry, M., Chilcott, J., Tappenden, P., Whyte, S., Staines, A., Greenberg, A., Fairclough, L., Roberts, W., Masterson Tavares Pereira Ferrera, D., Fonseca, E. R., Casado, L., McBride, M. L., Goddard, K., Lorenzi, M., Spinelli, J. J., Broemeling, A. M., Glickman, V., Pritchard, S., Siegel, L., Rogers, P. C., Sheps, S., Annunziata, M. A., Giovannini, L., Bianchet, K., Muzzatti, B., Berretta, M., Lleshi, A., Tirelli, U., Sisimayi, C. N., Sarwal, K., Torrance, H., Baili, P., Amati, C., Di Salvo, F., Frazzingaro, C., Sanz, N., Micheli, A.

    Tumori, vol. 95, no. 5, pp. 610-622

    Contributions to Journals: Articles

  • Biopsy and selective recall compared with immediate large loop excision in management of women with low grade abnormal cervical cytology referred for colposcopy: multicentre randomised controlled trial

    Sharp, L., Cruickshank, M., Little, J., Cotton, S., Harrild, K., Cochran, C., Duncan, I., Gray, N., Hammond, R., Smart, L., Thornton, A., Waugh, N., Woolley, C., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    British Medical Journal, vol. 339, b2548

    Contributions to Journals: Articles

  • Cytological surveillance compared with immediate referral for colposcopy in management of women with low grade cervical abnormalities: multicentre randomised controlled trial

    Little, J., Sharp, L., Cotton, S., Cruickshank, M., Duncan, I., Harrild, K., Jenkins, D., Smart, L., Waugh, N., Cochran, C., Gray, N., Hammond, R., Neal, K., Thornton, A. J., Woolley, C., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    British Medical Journal, vol. 339, b2546

    Contributions to Journals: Articles

  • Options for managing low grade cervical abnormalities detected at screening: cost effectiveness study

    Whynes, D., Philips, Z., Woolley, C., Cotton, S., Cruickshank, M., Harrild, K., Little, J., Neal, K., Sharp, L., Waugh, N., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    British Medical Journal, vol. 339, no. -, b2549

    Contributions to Journals: Articles

  • Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake

    Sharp, L., Little, J., Brockton, N. T., Cotton, S. C., Masson, L. F., Haites, N. E., Cassidy, J.

    British Journal of Nutrition, vol. 99, no. 2, pp. 379-389

    Contributions to Journals: Articles

  • Lifestyle and sociodemographic factors associated with high-risk HPV infection in UK women

    Cotton, S. C., Sharp, L., Seth, R., Masson, L. F., Little, J., Cruickshank, M. E., Neal, K., Waugh, N. R., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    British Journal of Cancer, vol. 97, no. 1, pp. 133-139

    Contributions to Journals: Articles

  • Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1

    Little, J., Sharp, L., Masson, L. F., Brockton, N. T., Cotton, S. C., Haites, N. E., Cassidy, J.

    International Journal of Cancer, vol. 119, no. 9, pp. 2155-2164

    Contributions to Journals: Articles

  • Reasons for participation and non-participation in a randomized controlled trial: postal questionnaire surveys of women eligible for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)

    Sharp, L., Cotton, S. C., Alexander, L., Williams, E., Gray, N. M., Reid, J. M., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    Clinical Trials, vol. 3, pp. 431-442

    Contributions to Journals: Articles

  • Trial of management of borderline and other low grade abnormal smears (TOMBOLA): Trial design

    Cotton, S. C., Sharp, L., Little, J., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    Contemporary Clinical Trials, vol. 27, no. 5, pp. 449-471

    Contributions to Journals: Articles

  • Enclosing a pen with a postal questionnaire can significantly increase the response rate

    Sharp, L., Cochran, C., Cotton, S. C., Gray, N. M., Gallagher, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    Journal of Clinical Epidemiology, vol. 59, no. 7, pp. 747-754

    Contributions to Journals: Articles

  • Psychological effects of a low-grade abnormal cervical smear test result:anxiety and associated factors

    Gray, N. M., sharp, L., Cotton, S. C., Masson, L. F., little, J., Walker, L. G., Avis, M., Philips, Z., Russell, I., Whynes, D. K., Cruickshank, M. E., Woolley, C. M., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    British Journal of Cancer, vol. 94, pp. 1253-1262

    Contributions to Journals: Articles

  • Refining the management of low-grade cervical abnormailities in the UK National Health Service and defining the potential for human papillomavirus testing: A commentary on emerging evidence

    Bentley, E., Cotton, S. C., Cruickshank, M. E., Duncan, I., Gray, N. M., Jenkins, D., little, J., Neal, K., Philips, Z., Russell, I., Seth, R., sharp, L., Waugh, N. R.

    Journal of Lower Genital Tract Disease, vol. 10, no. 1, pp. 26-38

    Contributions to Journals: Articles

  • Developing a questionnaire to measure the psychosocial impact of an abnormal cervical smear result and its subsequent management: the TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) trial.

    Gray, N. M., Sharp, L., Cotton, S. C., Avis, M., Philips, Z., Russell, I., Walker, L. G., Whynes, D. K., Little, J.

    Quality of Life Research, vol. 14, no. 6, pp. 1553-1562

    Contributions to Journals: Articles

  • Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer: A HuGE Review

    Masson, L. F., Sharp, L., Cotton, S. C., Little, J.

    American Journal of Epidemiology, vol. 161, no. 10, pp. 901-915

    Contributions to Journals: Articles

  • CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. A HuGE Review

    Sharp, L., Cardy, A. H., Cotton, S. C., Little, J.

    American Journal of Epidemiology, vol. 160, no. 8, pp. 729-740

    Contributions to Journals: Articles

  • Are lifestyle factors associated with infection with high risk human papilloma virus? results from TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)

    Cotton, S. C., Sharp, L., Seth, R.

    Journal of Epidemiology and Community Health, vol. 58, no. Supplement II

    Contributions to Journals: Articles

  • Dietary intake of folate and related micronutrients, genetic polymorphisms in MTHFR and colorectal cancer: a population based case-control study in Scotland

    Sharp, L., Little, J., Brockton, N. T., Cotton, S. C., Haites, N. E., Cassidy, J.

    The Journal of Nutrition, vol. 132 Supplement 11

    Contributions to Journals: Articles

  • Women’s experiences of having an abnormal smear result: qualitative analyses from TOMBOLA

    Gray, N. M., Sharp, L., Cotton, S. C., Little, J., Avis, M., Philips, Z., Walker, L. G., Duncan, I.

    Journal of Obstetrics and Gynaecology, vol. 22, pp. 107-111

    Contributions to Journals: Articles

  • Genetic polymorphisms in folate metabolism, dietary folate intake and colorectal cancer: a population-based case-control study

    Sharp, L., Little, J., Brockton, N. T., Cotton, S. C., Haites, N. E., Cassidy, J.

    Journal of Epidemiology and Community Health, vol. 55, no. Supplement 1

    Contributions to Journals: Articles

  • Glutathione S-transferase polymorphisms and colorectal cancer: A HuGE review

    Cotton, S. C., Sharp, L., Little, J., Brockton, N.

    American Journal of Epidemiology, vol. 151, pp. 732

    Contributions to Journals: Literature Reviews

  • N-Acetyltransferase polymorphisms and colorectal cancer: A HuGE review

    Brockton, N., Little, J., Sharp, L., Cotton, S. C.

    American Journal of Epidemiology, vol. 151, pp. 846-861

    Contributions to Journals: Literature Reviews

  • SEARCH international case-control study of childhood brain tumours: Role of index pregnancy and birth, and mother's reproductive history

    McCredie, M., Little, J., Cotton, S., Mueller, B., Peris-Bonet, R., Choi, N. W., Cordier, S., Filippini, G., Holly, E. A., Modan, B., Arslan, A., Preston-Martin, S.

    Paediatric and Perinatal Epidemiology, vol. 13, no. 3, pp. 325-341

    Contributions to Journals: Articles

  • Patterns of inter-organizational purchasing: Evolution of consortia-based purchasing amongst GP fundholders

    Laing, A., Cotton, S.

    European Journal of Purchasing and Supply Management, vol. 3, no. 2, pp. 83-91

    Contributions to Journals: Articles

  • The Adenoma-Carcinoma Sequence and Prospects for the Prevention of Colorectal Neoplasia

    Cotton, S., Sharp, L., Little, J.

    Critical Reviews in Oncogenesis, vol. 7, no. 5-6, pp. 293-342

    Contributions to Journals: Articles

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