Dr Seonaidh Cotton

Dr Seonaidh Cotton
BSc (Hons), MLitt, PhD

Senior Trial Manager

Overview
Dr Seonaidh Cotton
Dr Seonaidh Cotton

Contact Details

Telephone
work +44 (0)1224 438178
Fax
fax 01224 438165
Email
Address
The University of Aberdeen Health Services Research Unit Health Sciences Building (Third Floor) Foresterhill Aberdeen AB25 2ZD

Biography

I joined HSRU in 2007 as a trial manager.  I graduated from the University of Aberdeen with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007.  Prior to joining the Unit, I worked in the Department of Public Health at the University of Aberdeen.

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENOEMPOWER and ELECTRIC (all now completed).  I also worked as trial manager on a number of CHaRT trials, including TWICSCLASSNIAMIFOCCUSREFLUX and the Cysteamine in CF study.  

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

 


Qualifications

PhD, Public Health University of Aberdeen 2008
MLitt, by research University of Aberdeen 1994
BSc, Health Sciences University of Aberdeen 1993
Research

Research Areas


Research Overview

Trial methodology & trial management


Current Research

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.


Past Research

Since joining the Unit I have worked on a number of trials that have now been completed. 

TWICS  - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.

CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;

NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;

FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery

REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.

The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.

I also supported RAACENOEMPOWER and ELECTRIC (all now completed) as senior trial manager.

Teaching

Courses


Teaching Responsibilities

I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.

 

 


Non-Course Teaching Responsibilities

Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC).

 

Publications

Publications 

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  • A randomized trial comparing treatments for varicose veins

    Brittenden, J., Cotton, S. C., Elders, A., Ramsay, C. R., Norrie, J., Burr, J., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., Francis, J., Tassie, E., Scotland, G., Wileman, S., Campbell, M. K.

    The New England Journal of Medicine, vol. 371, no. 13, pp. 1218-1227

    Contributions to Journals: Articles

  • Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

    Siddiqi, N., Neil, C., Bruce, M., Maclennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J. C., Frenneaux, M., NIAMI investigators

    European Heart Journal, vol. 35, no. 19, pp. 1255-1262

    Contributions to Journals: Articles

  • The unintended consequences of cervical screening: distress in women undergoing cytologic surveillance

    Sharp, L., Cotton, S., Cruickshank, M., Gray, N. M., Harrild, K., Smart, L., Walker, L. G., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    Journal of Lower Genital Tract Disease, vol. 18, no. 2, pp. 142-150

    Contributions to Journals: Articles

  • Nitrites in Acute Myocardial Infarction

    Siddiqi, N., Bruce, M., Neil, C. J., MacLennan, G., Cotton, S., Papadopoulou, S. A., Jagpal, B., Brown, S., Gonzalez, F. P., Singh, S., Schwarz, K., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J., Frenneaux, M. P.

    Circulation, vol. 128, no. 24, pp. 2705

    Contributions to Journals: Abstracts

  • Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy

    Whynes, D. K., Sharp, L., Cotton, S. C., Cruickshank, M., Gray, N. M., Little, J., Waugh, N.

    European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 169, no. 1, pp. 88-92

    Contributions to Journals: Articles

  • Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial)

    Grant, A. M., Boachie, C., Cotton, S. C., Faria, R., Bojke, L., Epstein, D. M., Ramsay, C. R., Corbacho, B., Sculpher, M., Krukowski, Z. H., Heading, R. C., Campbell, M. K.

    Health Technology Assessment, vol. 17, no. 22, pp. 1-166

    Contributions to Journals: Articles

  • Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)

    Siddiqi, N., Bruce, M., Neil, C. J., Jagpal, B., MacLennan, G. S., Cotton, S. C., Papadopoulo, S. A., Bunce, N., Lim, P., Schwarz, K., Singh, S., Hildick-Smith, D., Horowitz, J. D., Madhani, M., Boon, N., Kaski, J., Dawson, D., Frenneaux, M. P.

    Journal of translational medicine, vol. 11, 116

    Contributions to Journals: Articles

  • Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX)

    Grant, A. M., Cotton, S. C., Boachie, C., Ramsay, C. R., Krukowski, Z. H., Heading, R. C., Campbell, M. K., REFLUX Trial Group

    BMJ, vol. 346, f1908

    Contributions to Journals: Articles

  • Which women default from follow-up cervical cytology tests? A cohort study within the TOMBOLA trial

    Sharp, L., Cotton, S., Thornton, A., Gray, N., Whynes, D., Smart, L., Waugh, N., Duncan, I., Cruickshank, M., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

    Cytopathology, vol. 23, no. 3, pp. 150-160

    Contributions to Journals: Articles

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