A retained placenta (RP) is a complication after a normal birth, which affects nearly 11,000 women in the UK a year. The recommended treatment for RP is a surgical procedure - manual removal of placenta (MROP). This is a painful and unpleasant procedure for the women, involving an additional stay in hospital, and is an additional cost for the NHS.
GOT-IT is a multi-centre randomised controlled blinded trial, funded by the NIHR HTA Programme, investigating whether treatment with oral Glyceryl trinitrate (GTN) is an effective treatment for retained placenta which will lead to a reduction in the number of women requiring manual removal of the placenta. Women with retained placenta will be randomised to either GTN or placebo.
GOT-IT will randomise 1100 women.
The trial is led by Dr Fiona Dennison based at the University of Edinburgh.