We design and deliver studies that explore participants' and researchers' experiences of many aspects of RCTs across a range of clinical areas and using a range of different methodologies. Some of these studies have been primary qualitative studies (using interviews, focus groups and non-participant observations) that have explored the following:
- patients experiences of the recruitment process;
- patients experiences of retention in trials;
- stakeholders (patients, trialists, research nurses, trial managers, ethics committee members) perceptions of how best to support informed decisions about trial participation and what outcomes matter for evaluation;
- development of measures of decision quality for RCT informed consent;
- trial site staff’s (consultants and research nurses) experiences of recruiting to RCTs;
- surgeons and methodologists perceptions and beliefs about expertise based RCTs;
- stakeholders’ beliefs and perceptions of placebo controlled surgery.
In addition to primary studies, we have also delivered a number of syntheses of qualitative studies exploring participant reported reasons for trial participation or drop-out.
Work in this area is actively ongoing across the portfolio of RCTs.
Katie Gillies; firstname.lastname@example.org
Louise Locock; email@example.com
Skea, V, Newlands, R, Gillies K. (2019) Exploring non-retention in clinical trials: a meta-ethnographic synthesis of studies reporting participant reasons for drop out BMJ Open, vol 9, no 6
Cook, JA, Campbell, MK, Gillies, K, Skea Z (2018) Surgeons' and methodologists' perceptions of utilising an expertise-based randomised controlled trial design: a qualitative study Trials. 2018 Sep 6;19(1):478. doi: 10.1186/s13063-018-2832-z
Boylan, A-M, Locock, L. & Machin, L. 'From waste product to blood, brains and narratives: developing a pluralist sociology of contributions to health research'. Sociology of Health & Illness
Skea, ZC, Treweek, S. & Gillies, K. (2017). 'It’s trying to manage the work”: A qualitative evaluation of recruitment processes within a UK multi-centre trial'. BMJ Open, vol 7, no. 8, pp. 1-8.
Locock, L. & Boylan, A-M (2016). 'Biosamples as gifts? How participants in biobanking projects talk about donation'. Health Expectations, vol 19, no. 4, pp. 805-816.
Gillies K, Entwistle V, Treweek SP, Fraser C, Williamson PR, Campbell MK. Evaluation of interventions for informed consent for randomised controlled trials (ELICIT): protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey. Trials. 2015 Oct 27;16:484.
Luchtenberg, M., Maeckelberghe, E., Locock, L., Powell, L. & Verhagen, AAE. (2015). 'Young People's Experiences of Participation in Clinical Trials: Reasons for Taking Part'. American Journal of Bioethics, vol 15, no. 11, pp. 3-13.