Projects undertaken by the Unit have contributed to the development of many different research tools for both researchers and users of research.
Sample Size calculator for cluster randomised trials
Version 2 of the sample size calculator is in development.
Please email Jemma Hudson (firstname.lastname@example.org) for a beta version.
The instruction manual for this program can be downloaded as a pdf file at the link below.
A further description of the calculator can be found in Campbell MK, Thomson S, Ramsay CR, MacLennan GS, Grimshaw JM. Sample size calculator for cluster randomised trials. Comput Biol Med 2004;34:113-125.
If you have any queries about the calculator, please contact Jemma Hudson (email@example.com).
In collaboration with colleagues at other Universities we have developed PRECIS-2, which is a tool to help trialists match their trial design decisions to the needs of the intended users of the trial results. PRECIS-2 has nine domains—eligibility criteria, recruitment, setting, organisation, flexibility (delivery), flexibility (adherence), follow-up, primary outcome, and primary analysis—scored from 1 (very explanatory design approach) to 5 (very pragmatic design approach) to facilitate domain discussion and consensus.
A website to support the use of the tool is available at www.precis-2.org
A description of PRECIS-2 can be found in Loudon K, Treweek S, Sullivan F, Donnan P, Thorpe KE, Zwarenstein M. The PRECIS-2 tool: designing trials that are fit for purpose. BMJ 2015;350:h2147 (http://www.bmj.com/content/350/bmj.h2147)
If you have any queries about the calculator, please contact Shaun Treweek (firstname.lastname@example.org).
Database of intra-correlation coefficients (ICCs)
A downloadable excel spreadsheet contains a list of intra-correlation coefficient calculated from a number of different interventions and settings. Also downloadable, is a list of references for the data contained in the spreadsheet.
- Implementation studies: Spreadsheet
- Implementation studies: References
- Surgical studies: Spreadsheet
Contamination in randomised trials
A flowchart was developed by the HTA Contamination in trials project to aid the decision on when a cluster randomised controlled trial might be preferred to a patient randomised controlled trial when contamination of controls are suspected.
Trial Protocol Tool
The Practihc collaboration developed a Trial Protocol Tool that supports the production of a high quality research protocol. It provides a checklist of issues that should be considered when writing a protocol. A paper describing the tool is available here.
Tool for conducting and managing RCTs
The DAMOCLES study formulated a list of considerations that would be valuable for a Data Monitoring Committee (DMC) to address at the start of a trial which were developed into a charter.
- Charter for DMCs: template (Word document)
- Worked example of the DAMOCLES charter (Word document)
HSRU offer a 24-hour, seven day telephone randomisation service and/or randomisation over the Web. For further information, click here.
Projects have contributed to guidance documents for reviewing and disseminating results of research.
- Producing information about health and health care interventions: a practical guide (PDF)
- How to identify and assess evidence from diagnostic studies of imaging: an introductory guide (PDF)