The randomised trial is increasingly being recognised as the gold-standard design to provide valid evidence on the effectiveness of different therapeutic interventions. Pragmatic trials, those which are undertaken in 'real world' health service settings, provide the most relevant information to clinical decision-makers, especially those which have been conducted to a high standard of quality. The global aims of the PRACTiHC Collaboration were:
- To study up to 100 partner experiences of pragmatic RCTs for high priority health problems and so to develop guidelines for improving their quality, relevance and use in decision-making.
- To systematically review the published literature on conduct of RCTs of interventions for high priority health problems in developing countries.
- To reinforce the capacity of developing countries to conduct high quality trials by developing and piloting a programme of trial development workshops in the design and conduct of trials.
- To promote the science of pragmatic randomised trials through dissemination workshops and publications and by extending training and support to neighbouring countries.
- To reinforce scientific and technological co-operation between researchers in developing countries and in the European Community.
There were 12 partner institutions world-wide (including European, African and South American partners). The primary contribution of the Health Services Research Unit was to locate or develop tools and resources to support the development and use of pragmatic trials and to make these accessible through the development of a Trial Protocol Tool.
Kirsty McCormack; firstname.lastname@example.org
Refereed Journal Papers
Shaun Treweek, Kirsty McCormack, Edgardo Abalos, Marion Campbell, Craig Ramsay, Merrick Zwarenstein on behalf of the Practihc collaboration. The Trial Protocol Tool: The PRACTiHC software tool that supported the writing of protocols for pragmatic randomized controlled trials. Journal of Clinical Epidemiology. 2006; 59:1127-33.
McCormack K, Treweek S, Abalos E, Campbell MK, Ramsay CR, Zwarenstein M et al. A software tool designed to assist with the production of trial protocols. Clinical Trials 2005;2(supp 1):565.
McCormack K, Treweek S, Abalos E, Campbell MK, Ramsay C, Lombard C, Zwarenstein M, on behalf of the PRACTIHC collaboration. The Trial Protocol Tool: a software tool designed to assist healthcare researchers with the production of a trial protocol. European and Developing Countries Clincial Trials Partnership conference, 3-5 October, Durban, South Africa 2005.
Kirsty McCormack, Shaun Treweek, Edgardo Abalos, Marion Campbell, Craig Ramsay, Merrick Zwarenstein for the PRACTiHC Collaboration. The Trial Protocol Tool: a software tool designed to assist with the production of trial protocols. The 26th Annual Meeting of the Society for Clinical Trials, Portland, Oregon, May 22-25, 2005.