Aberdeen Health Technology Assessment (HTA) Group

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Summary

The Aberdeen HTA Group is drawn from three departments of the Institute of Applied Health Sciences: the Health Services Research Unit, the Health Economics Research Unit and Public Health. This group undertakes technology assessment reviews (TARs) of the clinical effectiveness and cost-effectiveness of health care interventions for the NIHR Health Technology Assessment Programme on behalf of a range of policy makers, including the National Institute for Health and Clinical Excellence (NICE).   Work is commissioned by the National Institute for Health Research Evaluation, Trials and Studies Coordinating Centre (NETSCC).

Contact

Miriam Brazzelli; m.brazzelli@abdn.ac.uk

Status

Ongoing

Current Projects

Single Technology Assessments

None at present

Multiple Technology Assessments

None at present

Diagnostic Assessment Reviews

Multiple frequency bioimpedance devices (BCM - Body Composition Monitor, BioScan 920-II, BioScan touch i8, InBody S10, and MultiScan 5000) for fluid management in people with chronic kidney disease having dialysis

Health Technology Assessments

The clinical and cost-effectiveness of protocols using contrast-enhanced ultrasound and/or colour duplex ultrasound in the long-term surveillance of endovascular abdominal aortic aneurysm repair (EVAR)

The Effectiveness and cost-effectiveness of Surgical Treatments for womEn with stRess urinary incontinence: An evidence synthesis (ESTER)

Interventions for the treatment of painful bladder syndrome (eg Interstitial cystitis)

Completed Projects

Single Technology Assessments

Eluxadoline for treating irritable bowel syndrome with diarrhoea 

Enzalutamide - recommended by NICE

Ibrutinib - recommended by NICE

Radium-223 dichloride for treating metastatic hormone relapsed prostate cancer with bone metastases [ID576] Single Technology Appraisal

Pazopanib for the first line treatment of patients with advanced and/or metastatic renal cell carcinoma: A Single Technology Appraisal

Eltrombopag for the treatment of chronic idiopathic (immune) thrombocytopenic purpura (ITP): A Single Technology Appraisal

Romiplostim for the treatment of chronic immune or idiopathic thrombocytopenic purpura (ITP): A Single Technology Appraisal

Aflibercept solution for injection for the treatment of wet age-related macular degeneration

Dapagliflozin for the treatment of type 2 diabetes

Ranibizumab for the treatment of choroidal neovascularisation associated with pathological myopia

Secukinumab for treating moderate to severe plaque psoriasis

Alirocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia

Ezetimibe for treating primary (heterozygous-familial and non-familial) hypercholesterolaemia

Multiple Technology Assessments

Collagenase clostridium histolyticum for the treatment of Dupuytren’s contracture

Systematic review of the clinical and cost-effectiveness of imatinib at escalated doses of 600 mg/day or 800 mg/day for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours which have progressed on treatment at a dose of 400 mg/day

Systematic review of the clinical and cost-effectiveness, and economic evaluation of denosumab for the treatment of bone metastases from solid tumours

Diagnostic Assessment Reviews

Point-of-care tests (CoaguChek system, INRatio2 PT/INR monitor and ProTime Microcoagulation system) for the self-monitoring of the coagulation status of people receiving long-term vitamin K antagonist therapy compared with standard UK practice

The clinical and cost-effectiveness of Elucigene FH20 and LIPOchip for the diagnosis of familial hypercholesterolaemia: systematic review and economic evaluation

Health Technology Assessments

Open mesh repairs in adults presenting with a clinically diagnosed unilateral, primary inguinal hernia

Systematic review of the clinical and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer

Systematic review of the clinical and cost-effectiveness of rapid point-of-care tests for the detection of genital Chlamydia infection in women and men

Systematic review of the clinical and cost-effectiveness of 64-slice or higher computed tomography angiography as an alternative to invasive coronary angiography in the investigation of coronary artery disease (CAD)

Systematic review of the clinical effectiveness and cost-effectiveness of oesophageal Doppler monitoring in critically ill and high risk surgical patients

Systematic review of the clinical effectiveness and cost-effectiveness and economic modelling of minimal incision total hip replacement approaches in the management of arthritic disease of the hip

Clinical and cost-effectiveness of cholecystectomy versus observation/conservative management for preventing recurrent symptoms and complications in adults presenting with uncomplicated symptomatic gallstones or cholecystitis

MRS/MRI: Systematic review of the diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy