The Effectiveness and cost-effectiveness of Surgical Treatments for womEn with stRess urinary incontinence: an evidence synthesis (ESTER)


This NIHR HTA-funded project will assess the current evidence for the clinical effectiveness, safety and cost-effectiveness of surgical treatments for stress and stress-predominant urinary incontinence in women.  Current network meta-analysis methodology will be used to combine direct and indirect evidence in order to estimate treatment effects for surgical treatments where no direct head-to-head clinical trials have been conducted. This analysis will provide relative treatment effects for the surgical techniques under assessment. In addition, an economic model will be developed to estimate the cost-effectiveness of alternative surgical treatments and to undertake a value of information analysis. The results obtained will enable decision-makers to identify which type of surgery for stress urinary incontinence is most clinically effective, safest, and cost-effective for the NHS. The value of information analysis will be used to quantify the main uncertainties with regard to policy decision-making as  well as quantify the value of undertaking further research. The project, which started in August 2016, is funded for 14 months. 


Miriam Brazzelli


Data Collection - ongoing