Version 2 has a slightly different layout but it should be straightforward to use in conjunction with the Computers in Biology and Medicine paper. Unzip the files to a folder on your network (a flash drive will do) and click on the index.html inside the SampSizeV2 folder. This will open the calculator in a web browser. You need to have JavaScript enabled, this is the default setting for most browsers, but if you need to you can read about it here: http://www.enable-javascript.com/ Any questions, please get in touch, regards, Jemma.