Patients preferences for treatment of lower urinary tract symptoms

Patients' preferences for treatment of lower urinary tract symptoms: a discrete choice experiment

In this study, we used a mixed methods approach to establish men’s preferences for different lower urinary-tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) treatment characteristics, the impact of LUTS and LUTS treatment on their quality of life, and the trade-offs men are prepared to make between treatment characteristics and quality of life. Our mixed methods approach combined online focus groups and a DCE. The mixed methods approach provided a rich data set that can be used to explore preferences for treatment of LUTS/BPH.

Outcome and Translation

We find LUTS have a large impact on many aspects of men’s quality of life. Many men were reluctant to take medication in general. However, men value treatment that improves day-time frequency of urination, night-time frequency, and urgency of urination. A medicine targeting a mix of symptoms, with a particular focus on improving urgency combining either reducing night-time frequency or substantially reducing day-time frequency, is likely to have the highest benefit for patients.

HERU researchers involved in this research project: Divine Ikenwilo, Mandy Ryan, Verity Watson and Sebastian Heidenreich

Publications

Mankowski, C., Ikenwilo, D., Heidenreich, S., Ryan, M., Nazir, J., Newman, C. and Watson, V. (2016) 'Men’s preferences for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia: a discrete choice experiment', Patient Preference and Adherence, 10, 2407-2417.

Ikenwilo, D., Heidenreich, S., Ryan, M., Mankowski, C., Nazir, J. and Watson, V. (2017) 'The best of both worlds: an example mixed methods approach to understand men's preferences for the treatment of lower urinary tract symptoms', Patient, [Epub ahead of print].

Presentations

Ikenwilo, D., Watson, V., Chambers, C., Heidenreich, S., Newman, C., Nazir, J. and Ryan, M. (2014) 'Men’s preferences for the treatment of lower urinary tract symptoms associated with benign protstatic hyperplasia: a discrete choice experiment', [poster] International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 17th Annual European Congress, Amsterdam, 8-12 November 2014.

Ikenwilo, D., Watson, V., Chambers, C., Heidenreich, S., Newman, C., Nazir, J. and Ryan, M. (2014) 'A mixed-method approach to understanding men’s attitudes toward the management of lower urinary tract symptoms associated with benign prostatic hyperplasia', [poster] International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 17th Annual European Congress, Amsterdam, 8-12 November 2014