LIFT: Lessening the Impact of Fatigue: Therapies for inflammatory rheumatic diseases

Despite major advances in the management of inflammatory rheumatic diseases, fatigue continues to be a major problem for patients in day-to-day management of the condition. In rheumatoid arthritis, for example, as many as 80% of patients report significant fatigue and over 70% consider fatigue to be equal to pain. Moreover, fatigue is a crucial determinant of impaired quality of life and a predictor of work disability. There is now evidence that non-pharmacological interventions, specifically cognitive behavioural approaches and exercise therapies, are effective treatments for significant fatigue. However, it is difficult to access these therapies. This study tests whether remote delivery is effective and cost-effective, and will explore the factors that predict treatment success.


HERU researchers involved in this research project: Paul McNamee

External Collaborators: N. Basu (NHS Grampian); S. Siebert (NHS Greater Glasgow & Clyde); A. Wearden (Central Manchester University Hospitals Trust) and V. Kumar (NHS Tayside).


Martin, K.R., Bachmair, E.M., Aucott, L., Dures, E., Emsley, R., Gray, S.R., Hewlett, S., Kumar, V., Lovell, K., Macfarlane, G.J., MacLennan, G., McNamee, P., Norrie, J., Paul, L., Ralston, S., Siebert, S., Wearden, A., White, P.D. and Basu, N. (2019) 'Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT) [Protocol]', BMJ Open, 9(1), e026793.