TYRX Absorbable Antibacterial Envelope for preventing infection from cardiac implantable electronic devices

TYRX Absorbable Antibacterial Envelope for preventing infection from cardiac implantable electronic devices (Single Technology Assessment)

The Aberdeen Health Technology Group was commissioned by NICE as the Evidence Review Group (ERG) for this Single Technology Assessment (STA). The ERG reviewed all the clinical and economic evidence submitted by the company (Medtronic).

One randomised controlled trial (RCT) comparing the use of TYRX versus standard practice (no TYRX) formed the main source of clinical evidence (the WRAP-IT RCT). WRAP-IT was a prospective, single blind multicentre RCT involving nearly 7000 participants. The submitted cost-effectiveness evidence was based on decision tree informed by the WRAP-IT trial and other sources of evidence. The model recreated the possible care pathways (i.e. no infection, infection, partial/complete extraction with/without device replacement) out to 12 months post-surgery, and applied expected lifetime costs and QALYs, adapted from a previous NICE STA, as final pay-offs for survivors at 12 months.

The STA for TYRX Absorbable Antibacterial Envelope for preventing infection from cardiac implantable electronic devices is still ongoing and so the outcome of this project is not yet available. This assessment can be followed on the NICE website: TYRX Absorbable Antibacterial Envelope for preventing infection from cardiac implantable electronic devices [ID1440].

HERU researchers involved in this research project: Rodolfo Hernández and Graham Scotland

External collaborators: Ramsay, C., Brazzelli, M., Cummins, E. and Campbell, M. (Health Services Research Unit (HSRU), University of Aberdeen).

Publications

Hernández, R., Robertson, C., Scott, N., Scotland, G., Booth, C., Manson, P., Broadhurst, P. and Brazelli, M. (2019) TYRX Absorbable Antibacterial Envelope for preventing infection from cardiac implantable electronic devices, (NICE Technology Appraisal Guidance - GID-TA10370), Aberdeen Health Technology Assessment Group.