SIMS Pilot Study long term follow up

Long term follow up of the SIMS – PILOT study: Single Incision Mini-Slings versus standard mid-urethral slings in surgical management of female stress urinary incontinence

Stress urinary incontinence (SUI) is the most common type of urinary incontinence (UI) in pre-menopausal women, accounting for almost 50% of cases. Surgical procedures for the management of female SUI have been continuously evolving over the last four decades with the ultimate aim of providing an effective and truly ambulatory surgical procedure. However, evidence on the clinical and cost-effectiveness of new methods of surgery is lacking. Data are particularly scarce in relation to longer-term outcomes, such as resource implications, quality of life and failure rates of the respective treatments.

This project is an update of an earlier pilot study comparing single incision mini-slings (SIMS), performed under local anaesthetic with standard mid-urethral slings (SMUS) performed under general anaesthetic for the surgical treatment of SUI has already been conducted. An initial assessment of the one-year pilot data showed that there were no significant differences between randomised groups in terms of QoL or patient reported success rate. Analysis of the four-year follow-up data has been completed and papers are currently being written up for the project. 

Outcome and Translation

The purpose of the current study was to determine if initial cost-effectiveness results are maintained over longer term, four-year follow-up. Work from this project has already contributed to securing funding for a larger study to definitively determine the relative effectiveness, safety and cost-effectiveness of the respective interventions. This project therefore runs alongside the larger study of the SIMS intervention, which is currently on-going.

HERU researchers involved in this research project: Dwayne Boyers, Mary Kilonzo and Elisabet Jacobsen

External collaborators: M Abdel Fattah and A Mostafa (Other Applied Health Sciences, University of Aberdeen)