Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis? A randomised controlled trial
A randomised controlled trial is being undertaken to test whether bicarbonate treatment makes older people with advanced kidney disease healthier. 380 patients will receive either bicarbonate or dummy (placebo) tablets three times a day for two years. We test muscle strength and bulk, walking and balance ability, quality of life, kidney, bone and blood vessel function at intervals over the two-year period. We record blood pressure and side effects, record falls, admissions to hospital and contact with GPs, and also test the cost of treatment against the cost of not treating.
International Standard Randomised Controlled Trial Number Register number ISRCTN09486651
External collaborators: M Witham (University of Dundee), A Avenell (HSRU, University of Aberdeen) and R Soiza (School of Medicine, Medical Sciences and Nutrition, University of Aberdeen).
Witham, M. D., Band, M. M., Littleford, R. C., Avenell, A., Soiza, R. L., McMurdo, M. E., Sumukadas, D., Ogston, S. A., Lamb, E. J., Hampson, G. and McNamee, P. (2015) 'Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis (the BiCARB trial)? Study protocol for a randomized controlled trial [protocol]', Trials, 16(1), 326.
Witham, M.D., Band, M., Ahmed, A., Almond, M.K., Balasubramaniam, G., Basnayake, K., Bhatnagar, D., Chan, A., Chong, H.Y., Donnan, P.T., Duncan, N., Hampson, G., Hu, M.K., Kalra, P.A., Kennedy, G., Kirk, A., Lamb, E.J., Lambie, S., Littleford, R., McNamee, P., Mishra, B., Mitra, S., Nicholas, J., Plews, D., Rauchhaus, P., Soiza, R.L., Stevens, P.E., Sumukadas, D., Tse, W., Warwick, G., Wilkie, M., Winnett, G., Avenell, A. and the BiCARB Study Group (2020) 'Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): a pragmatic randomised, double-blind, placebo-controlled trial', BMC Medicine, 18(91).
Witham, M. D., Band, M., Chong, H., Donnan, P. T., Hampson, G., Hu, M. K., Littleford, R., Lamb, E., Kalra, P. A., Kennedy, G., McNamee, P., Plews, D., Rauchhaus, P., Soiza, R. L., Sumukadas, D., Warwick, G. and Avenell, A. (2020) 'Sodium bicarbonate to improve physical function in patients over 60 years with advanced chronic kidney disease: the BiCARB RCT', Health Technology Assessment, 24(27).