The place of minimal access surgery amongst people with gastro-oesophageal reflux disease - a UK collaborative study (the REFLUX trial)
Campbell, M., Grant, A. (HSRU, University of Aberdeen) Martin, I. (University of Auckland, New Zealand) Sculpher, M. (Centre for Health Economics, York) Krukowski, Z. (Grampian University Hospitals Trust, Aberdeen) Heading, R. (Edinburgh Royal Infirmary, Edinburgh) Darzi, A. (St Mary's Hospital, London) Russell, I. (University of York) and Vale, L. (HERU /HSRU)
The advent of minimal access techniques has greatly enhanced the potential value of surgery for persistent gastro-oesophageal reflux disease (GORD). The study involved the evaluation of clinical effectiveness and safety within a pragmatic trial, and the assessment of cost-effectiveness, likely patient preferences, and the implications of more extensive future use of surgery, within an economic evaluation. The HERU component of this study was to elicit, using Discrete Choice Experiment methodology, the strength of preference for alternative methods of management amongst participants in the study.
Grant, A., Wileman, S., Ramsay, C., Bojke, L., Epstein, D., Sculpher, M., Macran, S., Kilonzo, M., Vale, L., Francis, J., Mowat, A., Krukowski, Z., Heading, R., Thursz, M., Russell, I. and Campbell, M. on behalf of the REFLUX trial group. The effectiveness and cost-effectiveness of minimal access surgery amongst people with gastro-oesophageal reflux disease – a UK collaborative study. The REFLUX trial. Health Technology Assessment. 2008; 12(31): 1–214.
Grant, A., Wileman, S., Ramsay, C., Mowat, N., Krukowski, Z., Heading, R., Thursz., M., Campbell, M. and the REFLUX Trial Group (Vale, L.) Minimal access surgery compared with medical management for chronic gastro-oesophageal reflux disease: UK collaborative randomised trial. British Medical Journal. 2008; 337(7686): a2664.
Reflux Trial Group. (Vale, L.and Kilonzo, M. members) The place of minimal access surgery amongst people with gastro-oesophageal reflux disease – a UK collaborative study. The REFLUX Trial. Report submitted to NHS R&D HTA Programme, October 2006.
Cooper, K.G., Sambrook, A., Campbell, M.K., Cook, J.A., Kilonzo, M. and Vale, L. The Endometrial Ablation Study: A randomised comparison of treatment in the postmenstrual phase: Clinical outcomes, patient acceptability and cost. Report submitted to the Chief Scientist Office of the Scottish Executive Health Department, April 2007.
Kilonzo, M. Using Discrete Choice Experiments to measure preferences for treatment options an application to gastro-oesophageal reflux disease. Health Services Research Unit. University of Aberdeen, March 2007.
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