A randomised double blind placebo controlled trial of the effect of vitamin and mineral supplements on morbidity and mortality in men and women over 65
Avenell, A., Campbell, M., Milne, A., Robertson, C., Stephen, A. (HSRU, University of Aberdeen) Hannaford, P. (Centre of Academic Primary Care) McNeill, G. (Division of Applied Health Sciences, University of Aberdeen) Seymour, G. (Department of Medicine and Therapeutics, University of Aberdeen), Kilonzo, M. and Vale, L. (HERU/HSRU)
Evidence is required to ascertain whether improvement of nutritional status in older people in the community has important benefits and is an efficient use of health services resources. In total, 910 older, mainly non-institutionalised people were randomised to a daily multivitamin and multimineral supplement or placebo for one year. Primary outcomes were primary care contacts, self-reported days of infection and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events and compliance.
Vale, L., Kilonzo, M., Jonathan, C. for the MAVIS study group. The effect of vitamin and mineral supplements on infections in older people: a pragmatic randomised double-blind, placebo-controlled trial. Italian Journal of Public Health.2005; Year 3: 2(Supplement 1)
Writing Group on the MAVIS trial (Vale, L. a member of the group). Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomized, double-blind, placebo controlled trial. British Medical Journal. 2005; 331(7512): 324-320.
Writing Group of the MAVIS trial (Vale, L. a member of the group). Reply to correspondence about the MAVIS trial [letter]. British Medical Journal. 2005, 331, 324.
Avenell, A., Campbell, M., Cook, J., Milne, A., Ramsay, C., Stephen, A., Hannaford, P., Kilonzo, M.,Vale, L., McNeill, G. and Seymour, G. The key role of micronutrients. Clinical Nutrition. 2007; 26(1): 159.
Kilonzo, M., Vale, L.,Cook, J., Milne, A., Stephen, A., Avenell, A. and the MAVIS Trial Group. A cost-utility analysis of multivitamin and multimineral supplements in men and women aged 65 years and over. Clinical Nutrition. 2007; 26(3): 364–370.
McNeill, G., Avenell, A., Campbell, M.K., Cook, J.A., Hannaford, P.C., Kilonzo, M., Milne, A.C., Ramsay, C.R., Seymour, D.G., Stephen, A.I. and Vale, L. Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial. Nutrition Journal. 2007; 6: 10.
Vale, L, Kilonzo, M., Jonathan C. for the MAVIS study group. The effect of vitamin and mineral supplements on infections in older people: a pragmatic randomised double-blink, placebo-controlled trial. Health Technology Assessment International (HTAi). Rome. June 2005.