Testosterone Effects and Safety (TESTES)

Effects and Safety of Testosterone in Men with Low Testosterone levels:  an evidence synthesis and economic evaluation. The TESTES (Testosterone Effects and Safety) Consortium

Testosterone hormone is vital for sexual activity, bone growth and muscle development in men. Low testosterone levels may result in sexual problems, osteoporosis, weakness, low mood and tiredness. These symptoms can be treated with ART. Prescriptions of ART in men have nearly doubled within the last 10 years in the UK, yet the incidence of symptomatic men with low testosterone levels remains unchanged. Besides, there is conflicting evidence on the clinical effectiveness of ART with some studies suggesting a potential increased risk of cardiovascular events and prostate growth.

This project has three main components: 1) a systematic literature review (SLR) will identify relevant randomized controlled trials (RCTs), 2) a second SLR will be used to synthetize the existing qualitative evidence reporting men’s experience and acceptability of ART and 3) the development of a decision model to estimate the cost-effectiveness of ART for the treatment of symptomatic men with low testosterone.

As part of the project individual patient data (IPD) from relevant RCTs will be retrieved. The meta-analysis of these data will provide crucial inputs for the economic model.

HERU researchers involved in this research project: Rodolfo Hernández 

External collaborators: Jayasena, C. (Imperial College of Science, Technology and Medicine); Dhilo, W. (Imperial College London); Wu, F. (University of Manchester); Bhattacharya, S., Gillies, K., Brazzelli, M., Aucott, L. (University of Aberdeen); Quinton, R. (Freeman Hospital); Oliver, N. (Imperial College London).