EDNA: Early Detection of Neovascular Age-related macular degeneration

‘Wet’ or neovascular age-related macular degeneration (nAMD) is a leading cause of sight loss in older people. The EDNA study will evaluate five non-invasive diagnostic tests which are easily performed and routinely carried out in the NHS secondary care setting and which fall into two groups: functional and morphological.

The functional tests are visual acuity, Amsler test and self-reported quality of sight. The morphological tests are fundus examination and optical coherence tomography (OCT). The diagnostic accuracy of these tests will be assessed against a reference standard test (fluorescein angiography). The results from this prospective cohort study will be used to inform the development of a decision analytic model, which will model disease progression and the costs and consequences of using the alternative diagnostic test to monitor patients in secondary care. http://www.nets.nihr.ac.uk/projects/hta/1214207.

HERU researchers involved in this project: Graham Scotland

External collaborators: U Chakravarthy, R Hogg (Queen’s University Belfast); C Ramsay, K Bainster, J Cook, A Azuara-Blanco (HSRU, University of Aberdeen); S Sivaprasad (Moorfields Eye Hospital NHS Foundation Trust) and H Heimann (Royal Liverpool & Broadgreen University Hospitals NHS Trust).


Bannister, K., Cook, J., Scotland, G., Azuara-Blanco, A., Goulão, B., Heimann, H., Hernández, R., Hogg, R., Kennedy, C., Sivaprasad, S., Ramsay, C. and Chakravarthy, U. (2020) Early detection of neovascular age-related macular degeneration (EDNA): an evaluation of diagnostic accuracy, predictive factors, and cost-effectiveness. Final project report to National Institute for Health Research (NIHR) Health Technology Assessment Programme.