I work with calorie restriction, which in many mammals slows down the rate at which ageing, and ageing associated diseases occur. My main focus is looking at the responses of the metabolism to calorie restriction, and which of these metabolic responses are beneficial to the organism. At the moment I am focussing on how calorie restriction may be having a beneficial effect through the improvement of energy regulation. I use metabolomics (LC-MS) to explore calorie restricted tissues, which helps me determine which metabolic pathways are being affected. So far I have been focussing on energy dysregualtion and how calorie restriction can improve it through carnitines, bile acids and sphingolipids. @CaraLGreen
I am a third year PhD student at the University of Aberdeen and my research focuses on transcriptomic responses to calorie restriction. I am currently looking at the effects of ageing on gene expression in hypothalamus, liver and white adipose tissue and to what extent calorie restriction can reduce the impact of ageing. In addition, by using novel statistical approaches based on network analysis I am researching the effect of ageing on gene-gene interaction network connectivity and structure.
I am the first PhD student in the dual degree programme of the University of Aberdeen and University of Chinese Academy of Sciences. My study focus on the individual variability of the susceptibility of obesity. We are living in an obesogenic world with high energy density food increasing the excess in calories and new technology continuously reducing the necessity for energy expenditure. However, our body weight response is highly variable between individuals: some of us grow overweight or obesity while others remain lean. Genetic factors are reported to explain about 65% of the BMI variance. At present, I am working on the non-genetic factors that drive the remaining variation. I use C57BL/6 mouse because they mimic the individual variability of body weight gain in humans, but as they are highly inbred I can rule out the genetic factors. So far I have found detectable differences in hypothalamus gene expression levels between mice prone to obesity and the ones resistant to, which can be distinguished by observing an specific feeding behaviour. At the moment I am looking at the "hub" genes with differential expressions and trying to test their effectiveness by KO mouse model.
Emem Paul Udoh
Evidence from human and animal studies have shown that the regulation of feeding behaviour and maintenance of body mass is a complex process. After a period of calorie restriction, ie dieting, mechanisms drive increased feeding which is known as post-restriction hyperphagia. Together with a reduction in energy expenditure this leads to increased weight gain after a period of restriction. Within the Energetics Research Group I will examine the effects of duration on calorie restriction. Using a mouse model I will measure the physiological and molecular mechanisms regulating energy balance. Email:email@example.com
I am currently a first year PhD student researching the effect of reproduction on lifespan. Previously I completed my MSci degree at the University of Aberdeen working in the Energetics group on both my Honours and Masters theses, both of which explored the effect of maternal age on offspring susceptibility to obesity.